5M8S
Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with phenylthiourea (PTU)
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. ChCngNfsGHnC |
| Chain | Residue | Details |
| A | CYS99-CYS110 |
| site_id | PS00497 |
| Number of Residues | 18 |
| Details | TYROSINASE_1 Tyrosinase CuA-binding region signature. Hegpa.FLtWHRyhLlrlE |
| Chain | Residue | Details |
| A | HIS215-GLU232 |
| site_id | PS00498 |
| Number of Residues | 12 |
| Details | TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPiFVllHtftD |
| Chain | Residue | Details |
| A | ASP397-ASP408 |
| site_id | PS01248 |
| Number of Residues | 24 |
| Details | EGF_LAM_1 Laminin-type EGF-like (LE) domain signature. Ch.CngnfsGhnCgtCrpg.Wrgaa...........C |
| Chain | Residue | Details |
| A | CYS99-CYS122 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28661582","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5M8L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28661582","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5M8L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
