5M70
Crystal Structure of human RhoGAP mutated in its arginin finger (R85A) in complex with RhoA.GDP.AlF4- human
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, F) | Rho GTPase-activating protein 1 | polymer | 240 | 27188.1 | 2 | UniProt (Q07960) Pfam (PF00620) | Homo sapiens (Human) | CDC42 GTPase-activating protein,GTPase-activating protein rhoGAP,Rho-related small GTPase protein activator,Rho-type GTPase-activating protein 1,p50-RhoGAP |
| 2 | B, D (B, G) | Transforming protein RhoA | polymer | 192 | 21634.9 | 2 | UniProt (P61586) Pfam (PF00071) | Homo sapiens (Human) | Rho cDNA clone 12,h12 |
| 3 | E, H (B, G) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 4 | F, I (B, G) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 5 | G, J (B, G) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) PubChem (5311325) | |||
| 6 | K, L, M, N (A, B, F, G) | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A, F: 1 - 240 (UniProt: Q07960)
B, G: 2 - 193 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Ala 85 | Arg 282 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 25 | Phe 25 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97646.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1141.0 | |
| All* | Total formula weight | 98787.0 |
