5M70
Crystal Structure of human RhoGAP mutated in its arginin finger (R85A) in complex with RhoA.GDP.AlF4- human
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, F) | Rho GTPase-activating protein 1 | polymer | 240 | 27188.1 | 2 | UniProt (Q07960) Pfam (PF00620) | Homo sapiens (Human) | CDC42 GTPase-activating protein,GTPase-activating protein rhoGAP,Rho-related small GTPase protein activator,Rho-type GTPase-activating protein 1,p50-RhoGAP |
| 2 | B, D (B, G) | Transforming protein RhoA | polymer | 192 | 21634.9 | 2 | UniProt (P61586) Pfam (PF00071) | Homo sapiens (Human) | Rho cDNA clone 12,h12 |
| 3 | E, H (B, G) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F, I (B, G) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 5 | G, J (B, G) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) | |||
| 6 | K, L, M, N (A, B, F, G) | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A, F: 1 - 240 (UniProt: Q07960)
B, G: 2 - 193 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Ala 85 | Arg 282 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 25 | Phe 25 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97646.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1141.0 | |
| All* | Total formula weight | 98787.0 |
