5M5C
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Calmodulin-regulated spectrin-associated protein 1 | polymer | 118 | 13550.7 | 1 | UniProt (Q5T5Y3) Pfam (PF08683) | Homo sapiens (Human) | |
| 2 | B, D (D, A) | Tubulin alpha chain | polymer | 438 | 48638.8 | 2 | UniProt (F2Z4C1) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P81947) | Bos taurus (Bovine) | |
| 3 | C, E (E, B) | Tubulin beta-2B chain | polymer | 426 | 47809.7 | 2 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) | Bos taurus (Bovine) | |
| 4 | F, J (D, A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 5 | G, K (D, A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | H, L (E, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 7 | I, M (E, B) | TAXOL | non-polymer | 853.9 | 2 | Chemie (TA1) | |||
| 8 | N, O (D, A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
C: 1483 - 1600 (UniProt: Q5T5Y3)
D, A: 2 - 439 (UniProt: F2Z4C1)
E, B: 2 - 437 (UniProt: Q6B856)
| PDB | External Database | Details |
|---|---|---|
| Ala 1492 | Asn 1492 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 136 | Leu 136 | conflict |
| Gly 265 | Ile 265 | conflict |
| Glu 358 | Gln 358 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 57 | Thr 55 | conflict |
| Val 172 | Met 170 | conflict |
| Ala 298 | Ser 296 | conflict |
| Val 318 | Ile 316 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 206447.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3689.2 | |
| All* | Total formula weight | 210136.9 |
