5M5C
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000226 | biological_process | microtubule cytoskeleton organization |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0007399 | biological_process | nervous system development |
| B | 0015630 | cellular_component | microtubule cytoskeleton |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 1902669 | biological_process | positive regulation of axon guidance |
| C | 0005516 | molecular_function | calmodulin binding |
| C | 0008017 | molecular_function | microtubule binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000226 | biological_process | microtubule cytoskeleton organization |
| D | 0000278 | biological_process | mitotic cell cycle |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005200 | molecular_function | structural constituent of cytoskeleton |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005874 | cellular_component | microtubule |
| D | 0007017 | biological_process | microtubule-based process |
| D | 0015630 | cellular_component | microtubule cytoskeleton |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0000226 | biological_process | microtubule cytoskeleton organization |
| E | 0000278 | biological_process | mitotic cell cycle |
| E | 0003924 | molecular_function | GTPase activity |
| E | 0005200 | molecular_function | structural constituent of cytoskeleton |
| E | 0005525 | molecular_function | GTP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0005874 | cellular_component | microtubule |
| E | 0007017 | biological_process | microtubule-based process |
| E | 0007399 | biological_process | nervous system development |
| E | 0015630 | cellular_component | microtubule cytoskeleton |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0046982 | molecular_function | protein heterodimerization activity |
| E | 1902669 | biological_process | positive regulation of axon guidance |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue GTP D 501 |
| Chain | Residue |
| D | GLY10 |
| D | THR145 |
| D | GLY146 |
| D | ILE171 |
| D | THR179 |
| D | GLU183 |
| D | ASN206 |
| D | TYR224 |
| D | ASN228 |
| D | MG502 |
| D | HOH601 |
| D | GLN11 |
| D | HOH602 |
| D | HOH603 |
| D | HOH604 |
| E | LYS254 |
| D | ALA12 |
| D | GLN15 |
| D | ASP98 |
| D | ALA99 |
| D | ASN101 |
| D | GLY143 |
| D | GLY144 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 502 |
| Chain | Residue |
| D | GLN11 |
| D | GTP501 |
| D | HOH602 |
| D | HOH603 |
| D | HOH604 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue GDP E 501 |
| Chain | Residue |
| E | GLN11 |
| E | CYS12 |
| E | GLN15 |
| E | ASN101 |
| E | GLY143 |
| E | GLY144 |
| E | THR145 |
| E | GLY146 |
| E | GLU183 |
| E | ASN206 |
| E | TYR224 |
| E | ASN228 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue TA1 E 502 |
| Chain | Residue |
| E | ASP26 |
| E | GLU27 |
| E | ASP226 |
| E | HIS229 |
| E | LEU230 |
| E | ALA233 |
| E | SER236 |
| E | PRO274 |
| E | THR276 |
| E | ARG369 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | binding site for residue GTP A 501 |
| Chain | Residue |
| A | GLY10 |
| A | GLN11 |
| A | ALA12 |
| A | GLN15 |
| A | ASP98 |
| A | ASN101 |
| A | GLY143 |
| A | GLY144 |
| A | THR145 |
| A | GLY146 |
| A | ILE171 |
| A | THR179 |
| A | GLU183 |
| A | ASN206 |
| A | TYR224 |
| A | ASN228 |
| A | MG502 |
| A | HOH601 |
| A | HOH602 |
| A | HOH603 |
| A | HOH604 |
| B | LYS254 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | THR145 |
| A | GTP501 |
| A | HOH601 |
| A | HOH604 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue GDP B 501 |
| Chain | Residue |
| B | GLY10 |
| B | GLN11 |
| B | CYS12 |
| B | GLN15 |
| B | ILE16 |
| B | ASN101 |
| B | GLY143 |
| B | GLY144 |
| B | THR145 |
| B | GLY146 |
| B | GLU183 |
| B | ASN206 |
| B | TYR224 |
| B | ASN228 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue TA1 B 502 |
| Chain | Residue |
| B | ARG369 |
| B | LEU371 |
| B | VAL23 |
| B | ASP26 |
| B | GLU27 |
| B | ASP226 |
| B | HIS229 |
| B | LEU230 |
| B | SER236 |
| B | PRO274 |
| B | THR276 |
Functional Information from PROSITE/UniProt
| site_id | PS00227 |
| Number of Residues | 7 |
| Details | TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG |
| Chain | Residue | Details |
| E | GLY142-GLY148 | |
| D | GLY142-GLY148 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| D | GLU254 | |
| B | GLY144 | |
| B | THR145 | |
| B | GLY146 | |
| B | ASN206 | |
| B | ASN228 | |
| A | GLU254 | |
| E | GLY144 | |
| E | THR145 | |
| E | GLY146 | |
| E | ASN206 | |
| E | ASN228 | |
| B | GLN11 | |
| B | SER140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| D | GLN11 | |
| A | GLU71 | |
| A | SER140 | |
| A | GLY144 | |
| A | THR145 | |
| A | THR179 | |
| A | ASN206 | |
| A | ASN228 | |
| D | GLU71 | |
| D | SER140 | |
| D | GLY144 | |
| D | THR145 | |
| D | THR179 | |
| D | ASN206 | |
| D | ASN228 | |
| A | GLN11 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| D | LYS40 | |
| A | LYS40 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| D | SER48 | |
| D | GLY232 | |
| A | SER48 | |
| A | GLY232 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| D | TYR282 | |
| A | TYR282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| D | ARG339 | |
| A | ARG339 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| D | SER439 | |
| A | SER439 | |
| B | THR287 | |
| B | THR292 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| D | LYS326 | |
| B | ARG320 | |
| D | LYS370 | |
| A | LYS326 | |
| A | LYS370 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437 |
| Chain | Residue | Details |
| E | LYS60 | |
| B | LYS60 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 |
| Chain | Residue | Details |
| E | LYS326 | |
| B | LYS326 |
