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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5M32

Human 26S proteasome in complex with Oprozomib

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, OProteasome subunit alpha type-2polymer23425927.52UniProt (P25787)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3
2B, PProteasome subunit alpha type-4polymer26129525.82UniProt (P25789)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L
3CProteasome subunit alpha type-7polymer23426164.71UniProt (O14818)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Proteasome subunit RC6-1,Proteasome subunit XAPC7
4D, RProteasome subunit alpha type-5polymer24126436.02UniProt (P28066)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain
5EProteasome subunit alpha type-1polymer23426203.81UniProt (P25786)
Pfam (PF00227)
Pfam (PF10584)
In PDB		Homo sapiens (Human)30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain
6F, TProteasome subunit alpha type-3polymer25528469.32UniProt (P25788)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8
7G, UProteasome subunit alpha type-6polymer24627432.52UniProt (P60900)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain
8H, VProteasome subunit beta type-7polymer27730000.42UniProt (Q99436)
Pfam (PF00227)
Pfam (PF12465)
In PDB		Homo sapiens (Human)Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z
9I, WProteasome subunit beta type-3polymer20522972.92UniProt (P49720)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain
10J, XProteasome subunit beta type-2polymer19622349.72UniProt (P49721)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I
11K, YProteasome subunit beta type-5polymer20422484.42UniProt (P28074)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X
12L, ZProteasome subunit beta type-1polymer24126522.42UniProt (P20618)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain
13M, aProteasome subunit beta type-4polymer26429231.22UniProt (P28070)
Pfam (PF00227)
In PDB		Homo sapiens (Human)26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3
14N, bProteasome subunit beta type-6polymer23925377.72UniProt (P28072)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y
15QProteasome subunit alpha type-7polymer23526351.01UniProt (O14818)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Proteasome subunit RC6-1,Proteasome subunit XAPC7
16SProteasome subunit alpha type-1polymer23826632.31UniProt (P25786)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain
17c26S protease regulatory subunit 7polymer43348700.81UniProt (P35998)
Pfam (PF21236)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2,Protein MSS1
18d26S protease regulatory subunit 4polymer42847914.01UniProt (P62191)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1
19e26S protease regulatory subunit 6Bpolymer41847426.11UniProt (P43686)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7
20f26S protease regulatory subunit 10Bpolymer37943065.61UniProt (P62333)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT4,Proteasome 26S subunit ATPase 6,Proteasome subunit p42
21g26S protease regulatory subunit 6Apolymer43949266.51UniProt (P17980)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1
22h26S protease regulatory subunit 8polymer35539818.31UniProt (P62195)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG
23i26S proteasome non-ATPase regulatory subunit 1polymer953105958.21UniProt (Q99460)
Pfam (PF21505)
Pfam (PF01851)
Pfam (PF13646)
Pfam (PF18004)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN2,26S proteasome regulatory subunit S1,26S proteasome subunit p112
24j26S proteasome non-ATPase regulatory subunit 3polymer53461066.51UniProt (O43242)
Pfam (PF01399)
Pfam (PF08375)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,Proteasome subunit p58
25k26S proteasome non-ATPase regulatory subunit 12polymer45652979.41UniProt (O00232)
Pfam (PF01399)
Pfam (PF18098)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN5,26S proteasome regulatory subunit p55
26l26S proteasome non-ATPase regulatory subunit 11polymer42247526.71UniProt (O00231)
Pfam (PF18055)
Pfam (PF01399)
Pfam (PF18503)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN6,26S proteasome regulatory subunit S9,26S proteasome regulatory subunit p44.5
27m26S proteasome non-ATPase regulatory subunit 6polymer38945592.31UniProt (Q15008)
Pfam (PF10602)
Pfam (PF01399)
Pfam (PF21154)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN7,26S proteasome regulatory subunit S10,Breast cancer-associated protein SGA-113M,Phosphonoformate immuno-associated protein 4,Proteasome regulatory particle subunit p44S10,p42A
28n26S proteasome non-ATPase regulatory subunit 7polymer32437086.41UniProt (P51665)
Pfam (PF01398)
Pfam (PF13012)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40
29o26S proteasome non-ATPase regulatory subunit 13polymer37642995.41UniProt (Q9UNM6)
Pfam (PF01399)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN9,26S proteasome regulatory subunit S11,26S proteasome regulatory subunit p40.5
30p26S proteasome non-ATPase regulatory subunit 4polymer37740781.61UniProt (P55036)
Pfam (PF13519)
Pfam (PF02809)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN10,26S proteasome regulatory subunit S5A,Antisecretory factor 1,ASF,Multiubiquitin chain-binding protein
31q26S proteasome non-ATPase regulatory subunit 14polymer31034620.01UniProt (O00487)
Pfam (PF01398)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1
32r26S proteasome non-ATPase regulatory subunit 8polymer35039667.91UniProt (P48556)
Pfam (PF10075)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,p31
33s26S proteasome complex subunit SEM1polymer708284.61UniProt (P60896)
Pfam (PF05160)
In PDB		Homo sapiens (Human)26S proteasome complex subunit DSS1,Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein
34t, ubound Oprozomibpolymer4536.62Synthetic construct
35h, c, d, e, gADENOSINE-5'-DIPHOSPHATEnon-polymer427.26Chemie (ADP)
Sequence modifications
C: 2 - 235 (UniProt: O14818)
PDBExternal DatabaseDetails
Ala 48Lys 48conflict
Asp 179Glu 179conflict
Glu 200Gln 200conflict
E: 4 - 237 (UniProt: P25786)
PDBExternal DatabaseDetails
Asp 185Asn 185conflict
Asp 234Glu 234conflict
J, X: 1 - 196 (UniProt: P49721)
PDBExternal DatabaseDetails
Val 182Ile 182conflict
Asp 186Asn 186conflict
Asn 190Asp 190conflict
Glu 192Asp 192conflict
Ala 195Ser 195conflict
Q: 2 - 236 (UniProt: O14818)
PDBExternal DatabaseDetails
Asp 179Glu 179conflict
S: 2 - 239 (UniProt: P25786)
PDBExternal DatabaseDetails
Ala 2Phe 2conflict
Ala 3Arg 3conflict
Asp 185Asn 185conflict
Asp 234Glu 234conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains47
Total formula weight1532634.9
Non-Polymers*Number of molecules6
Total formula weight2563.2
All*Total formula weight1535198.1
*Water molecules are not included.

218853

PDB entries from 2024-04-24

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