5M32

Human 26S proteasome in complex with Oprozomib

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006281	biological_process	DNA repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0008021	cellular_component	synaptic vesicle
A	0009615	biological_process	response to virus
A	0010498	biological_process	proteasomal protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030317	biological_process	flagellated sperm motility
A	0032729	biological_process	positive regulation of type II interferon production
A	0032743	biological_process	positive regulation of interleukin-2 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0034341	biological_process	response to type II interferon
A	0034515	cellular_component	proteasome storage granule
A	0034774	cellular_component	secretory granule lumen
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
A	0045061	biological_process	thymic T cell selection
A	0045063	biological_process	T-helper 1 cell differentiation
A	0045590	biological_process	negative regulation of regulatory T cell differentiation
A	0051321	biological_process	meiotic cell cycle
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	0071357	biological_process	cellular response to type I interferon
A	0072539	biological_process	T-helper 17 cell differentiation
A	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006281	biological_process	DNA repair
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007283	biological_process	spermatogenesis
B	0008021	cellular_component	synaptic vesicle
B	0010498	biological_process	proteasomal protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030317	biological_process	flagellated sperm motility
B	0032729	biological_process	positive regulation of type II interferon production
B	0032743	biological_process	positive regulation of interleukin-2 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0034341	biological_process	response to type II interferon
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
B	0045061	biological_process	thymic T cell selection
B	0045063	biological_process	T-helper 1 cell differentiation
B	0045590	biological_process	negative regulation of regulatory T cell differentiation
B	0051321	biological_process	meiotic cell cycle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	0070062	cellular_component	extracellular exosome
B	0071357	biological_process	cellular response to type I interferon
B	0072539	biological_process	T-helper 17 cell differentiation
B	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
C	0000502	cellular_component	proteasome complex
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0006979	biological_process	response to oxidative stress
C	0008021	cellular_component	synaptic vesicle
C	0010498	biological_process	proteasomal protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030317	biological_process	flagellated sperm motility
C	0032729	biological_process	positive regulation of type II interferon production
C	0032743	biological_process	positive regulation of interleukin-2 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0034341	biological_process	response to type II interferon
C	0034515	cellular_component	proteasome storage granule
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
C	0045061	biological_process	thymic T cell selection
C	0045063	biological_process	T-helper 1 cell differentiation
C	0045590	biological_process	negative regulation of regulatory T cell differentiation
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	0071357	biological_process	cellular response to type I interferon
C	0072539	biological_process	T-helper 17 cell differentiation
C	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
C	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	0000502	cellular_component	proteasome complex
D	0002376	biological_process	immune system process
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006281	biological_process	DNA repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0007283	biological_process	spermatogenesis
D	0008021	cellular_component	synaptic vesicle
D	0010498	biological_process	proteasomal protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030317	biological_process	flagellated sperm motility
D	0032729	biological_process	positive regulation of type II interferon production
D	0032743	biological_process	positive regulation of interleukin-2 production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0034341	biological_process	response to type II interferon
D	0034515	cellular_component	proteasome storage granule
D	0034774	cellular_component	secretory granule lumen
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
D	0045061	biological_process	thymic T cell selection
D	0045063	biological_process	T-helper 1 cell differentiation
D	0045590	biological_process	negative regulation of regulatory T cell differentiation
D	0051321	biological_process	meiotic cell cycle
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	0071357	biological_process	cellular response to type I interferon
D	0072539	biological_process	T-helper 17 cell differentiation
D	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0002376	biological_process	immune system process
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006281	biological_process	DNA repair
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0006979	biological_process	response to oxidative stress
F	0007283	biological_process	spermatogenesis
F	0008021	cellular_component	synaptic vesicle
F	0010498	biological_process	proteasomal protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030317	biological_process	flagellated sperm motility
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032729	biological_process	positive regulation of type II interferon production
F	0032743	biological_process	positive regulation of interleukin-2 production
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0034341	biological_process	response to type II interferon
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
F	0045061	biological_process	thymic T cell selection
F	0045063	biological_process	T-helper 1 cell differentiation
F	0045590	biological_process	negative regulation of regulatory T cell differentiation
F	0051321	biological_process	meiotic cell cycle
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0061136	biological_process	regulation of proteasomal protein catabolic process
F	0070062	cellular_component	extracellular exosome
F	0071357	biological_process	cellular response to type I interferon
F	0072539	biological_process	T-helper 17 cell differentiation
F	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0002376	biological_process	immune system process
G	0003723	molecular_function	RNA binding
G	0004175	molecular_function	endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0006281	biological_process	DNA repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0008021	cellular_component	synaptic vesicle
G	0010498	biological_process	proteasomal protein catabolic process
G	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0030317	biological_process	flagellated sperm motility
G	0032729	biological_process	positive regulation of type II interferon production
G	0032743	biological_process	positive regulation of interleukin-2 production
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0034341	biological_process	response to type II interferon
G	0034515	cellular_component	proteasome storage granule
G	0035639	molecular_function	purine ribonucleoside triphosphate binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
G	0045061	biological_process	thymic T cell selection
G	0045063	biological_process	T-helper 1 cell differentiation
G	0045590	biological_process	negative regulation of regulatory T cell differentiation
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051321	biological_process	meiotic cell cycle
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0070062	cellular_component	extracellular exosome
G	0071357	biological_process	cellular response to type I interferon
G	0072539	biological_process	T-helper 17 cell differentiation
G	0097229	cellular_component	sperm end piece
G	0097542	cellular_component	ciliary tip
G	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
G	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
H	0000502	cellular_component	proteasome complex
H	0004175	molecular_function	endopeptidase activity
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0006281	biological_process	DNA repair
H	0006508	biological_process	proteolysis
H	0006915	biological_process	apoptotic process
H	0006974	biological_process	DNA damage response
H	0006979	biological_process	response to oxidative stress
H	0007283	biological_process	spermatogenesis
H	0008021	cellular_component	synaptic vesicle
H	0008233	molecular_function	peptidase activity
H	0010498	biological_process	proteasomal protein catabolic process
H	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
H	0016604	cellular_component	nuclear body
H	0016787	molecular_function	hydrolase activity
H	0019774	cellular_component	proteasome core complex, beta-subunit complex
H	0030317	biological_process	flagellated sperm motility
H	0034515	cellular_component	proteasome storage granule
H	0034774	cellular_component	secretory granule lumen
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051321	biological_process	meiotic cell cycle
H	0051603	biological_process	proteolysis involved in protein catabolic process
H	0061136	biological_process	regulation of proteasomal protein catabolic process
H	0071357	biological_process	cellular response to type I interferon
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
I	0000502	cellular_component	proteasome complex
I	0002376	biological_process	immune system process
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0006281	biological_process	DNA repair
I	0006915	biological_process	apoptotic process
I	0006974	biological_process	DNA damage response
I	0006979	biological_process	response to oxidative stress
I	0007283	biological_process	spermatogenesis
I	0008021	cellular_component	synaptic vesicle
I	0010498	biological_process	proteasomal protein catabolic process
I	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0030317	biological_process	flagellated sperm motility
I	0032729	biological_process	positive regulation of type II interferon production
I	0032743	biological_process	positive regulation of interleukin-2 production
I	0032760	biological_process	positive regulation of tumor necrosis factor production
I	0034341	biological_process	response to type II interferon
I	0034515	cellular_component	proteasome storage granule
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
I	0045061	biological_process	thymic T cell selection
I	0045063	biological_process	T-helper 1 cell differentiation
I	0045590	biological_process	negative regulation of regulatory T cell differentiation
I	0051321	biological_process	meiotic cell cycle
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0061136	biological_process	regulation of proteasomal protein catabolic process
I	0070062	cellular_component	extracellular exosome
I	0071357	biological_process	cellular response to type I interferon
I	0072539	biological_process	T-helper 17 cell differentiation
I	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
I	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
J	0000502	cellular_component	proteasome complex
J	0002376	biological_process	immune system process
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006281	biological_process	DNA repair
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0006979	biological_process	response to oxidative stress
J	0007283	biological_process	spermatogenesis
J	0008021	cellular_component	synaptic vesicle
J	0010498	biological_process	proteasomal protein catabolic process
J	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
J	0016020	cellular_component	membrane
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0030317	biological_process	flagellated sperm motility
J	0032729	biological_process	positive regulation of type II interferon production
J	0032743	biological_process	positive regulation of interleukin-2 production
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0034341	biological_process	response to type II interferon
J	0034515	cellular_component	proteasome storage granule
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
J	0045061	biological_process	thymic T cell selection
J	0045063	biological_process	T-helper 1 cell differentiation
J	0045590	biological_process	negative regulation of regulatory T cell differentiation
J	0051321	biological_process	meiotic cell cycle
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0061136	biological_process	regulation of proteasomal protein catabolic process
J	0070062	cellular_component	extracellular exosome
J	0071357	biological_process	cellular response to type I interferon
J	0072539	biological_process	T-helper 17 cell differentiation
J	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
J	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005839	cellular_component	proteasome core complex
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0002376	biological_process	immune system process
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0006281	biological_process	DNA repair
L	0006915	biological_process	apoptotic process
L	0006974	biological_process	DNA damage response
L	0006979	biological_process	response to oxidative stress
L	0007283	biological_process	spermatogenesis
L	0008021	cellular_component	synaptic vesicle
L	0010498	biological_process	proteasomal protein catabolic process
L	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
L	0019774	cellular_component	proteasome core complex, beta-subunit complex
L	0030317	biological_process	flagellated sperm motility
L	0032729	biological_process	positive regulation of type II interferon production
L	0032743	biological_process	positive regulation of interleukin-2 production
L	0032760	biological_process	positive regulation of tumor necrosis factor production
L	0034341	biological_process	response to type II interferon
L	0034515	cellular_component	proteasome storage granule
L	0034774	cellular_component	secretory granule lumen
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
L	0045061	biological_process	thymic T cell selection
L	0045063	biological_process	T-helper 1 cell differentiation
L	0045590	biological_process	negative regulation of regulatory T cell differentiation
L	0051321	biological_process	meiotic cell cycle
L	0051603	biological_process	proteolysis involved in protein catabolic process
L	0061136	biological_process	regulation of proteasomal protein catabolic process
L	0070062	cellular_component	extracellular exosome
L	0071357	biological_process	cellular response to type I interferon
L	0072539	biological_process	T-helper 17 cell differentiation
L	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
L	1904813	cellular_component	ficolin-1-rich granule lumen
L	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
M	0000502	cellular_component	proteasome complex
M	0001530	molecular_function	lipopolysaccharide binding
M	0002376	biological_process	immune system process
M	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0006281	biological_process	DNA repair
M	0006915	biological_process	apoptotic process
M	0006974	biological_process	DNA damage response
M	0006979	biological_process	response to oxidative stress
M	0007283	biological_process	spermatogenesis
M	0008021	cellular_component	synaptic vesicle
M	0010498	biological_process	proteasomal protein catabolic process
M	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
M	0019774	cellular_component	proteasome core complex, beta-subunit complex
M	0030317	biological_process	flagellated sperm motility
M	0032729	biological_process	positive regulation of type II interferon production
M	0032743	biological_process	positive regulation of interleukin-2 production
M	0032760	biological_process	positive regulation of tumor necrosis factor production
M	0034341	biological_process	response to type II interferon
M	0034515	cellular_component	proteasome storage granule
M	0036064	cellular_component	ciliary basal body
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
M	0045061	biological_process	thymic T cell selection
M	0045063	biological_process	T-helper 1 cell differentiation
M	0045590	biological_process	negative regulation of regulatory T cell differentiation
M	0051321	biological_process	meiotic cell cycle
M	0051603	biological_process	proteolysis involved in protein catabolic process
M	0061136	biological_process	regulation of proteasomal protein catabolic process
M	0070062	cellular_component	extracellular exosome
M	0071357	biological_process	cellular response to type I interferon
M	0072539	biological_process	T-helper 17 cell differentiation
M	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
M	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0006281	biological_process	DNA repair
N	0006508	biological_process	proteolysis
N	0006915	biological_process	apoptotic process
N	0006974	biological_process	DNA damage response
N	0006979	biological_process	response to oxidative stress
N	0007283	biological_process	spermatogenesis
N	0008021	cellular_component	synaptic vesicle
N	0008233	molecular_function	peptidase activity
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N	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
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N	0070062	cellular_component	extracellular exosome
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N	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
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O	0000932	cellular_component	P-body
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O	0005829	cellular_component	cytosol
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O	0006974	biological_process	DNA damage response
O	0006979	biological_process	response to oxidative stress
O	0007283	biological_process	spermatogenesis
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O	0009615	biological_process	response to virus
O	0010498	biological_process	proteasomal protein catabolic process
O	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030317	biological_process	flagellated sperm motility
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O	0032743	biological_process	positive regulation of interleukin-2 production
O	0032760	biological_process	positive regulation of tumor necrosis factor production
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O	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
O	0045061	biological_process	thymic T cell selection
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O	0070062	cellular_component	extracellular exosome
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O	1904813	cellular_component	ficolin-1-rich granule lumen
O	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0002376	biological_process	immune system process
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P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
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P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006915	biological_process	apoptotic process
P	0006974	biological_process	DNA damage response
P	0006979	biological_process	response to oxidative stress
P	0007283	biological_process	spermatogenesis
P	0008021	cellular_component	synaptic vesicle
P	0010498	biological_process	proteasomal protein catabolic process
P	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0030317	biological_process	flagellated sperm motility
P	0032729	biological_process	positive regulation of type II interferon production
P	0032743	biological_process	positive regulation of interleukin-2 production
P	0032760	biological_process	positive regulation of tumor necrosis factor production
P	0034341	biological_process	response to type II interferon
P	0034515	cellular_component	proteasome storage granule
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
P	0045061	biological_process	thymic T cell selection
P	0045063	biological_process	T-helper 1 cell differentiation
P	0045590	biological_process	negative regulation of regulatory T cell differentiation
P	0051321	biological_process	meiotic cell cycle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	0071357	biological_process	cellular response to type I interferon
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Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006281	biological_process	DNA repair
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0006915	biological_process	apoptotic process
Q	0006974	biological_process	DNA damage response
Q	0006979	biological_process	response to oxidative stress
Q	0008021	cellular_component	synaptic vesicle
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0030317	biological_process	flagellated sperm motility
Q	0032729	biological_process	positive regulation of type II interferon production
Q	0032743	biological_process	positive regulation of interleukin-2 production
Q	0032760	biological_process	positive regulation of tumor necrosis factor production
Q	0034341	biological_process	response to type II interferon
Q	0034515	cellular_component	proteasome storage granule
Q	0042802	molecular_function	identical protein binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
Q	0045061	biological_process	thymic T cell selection
Q	0045063	biological_process	T-helper 1 cell differentiation
Q	0045590	biological_process	negative regulation of regulatory T cell differentiation
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0061136	biological_process	regulation of proteasomal protein catabolic process
Q	0070062	cellular_component	extracellular exosome
Q	0071357	biological_process	cellular response to type I interferon
Q	0072539	biological_process	T-helper 17 cell differentiation
Q	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
Q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
R	0000502	cellular_component	proteasome complex
R	0002376	biological_process	immune system process
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006281	biological_process	DNA repair
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006915	biological_process	apoptotic process
R	0006974	biological_process	DNA damage response
R	0006979	biological_process	response to oxidative stress
R	0007283	biological_process	spermatogenesis
R	0008021	cellular_component	synaptic vesicle
R	0010498	biological_process	proteasomal protein catabolic process
R	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030317	biological_process	flagellated sperm motility
R	0032729	biological_process	positive regulation of type II interferon production
R	0032743	biological_process	positive regulation of interleukin-2 production
R	0032760	biological_process	positive regulation of tumor necrosis factor production
R	0034341	biological_process	response to type II interferon
R	0034515	cellular_component	proteasome storage granule
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
R	0045061	biological_process	thymic T cell selection
R	0045063	biological_process	T-helper 1 cell differentiation
R	0045590	biological_process	negative regulation of regulatory T cell differentiation
R	0051321	biological_process	meiotic cell cycle
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0061136	biological_process	regulation of proteasomal protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	0071357	biological_process	cellular response to type I interferon
R	0072539	biological_process	T-helper 17 cell differentiation
R	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
R	1904813	cellular_component	ficolin-1-rich granule lumen
R	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
S	0000502	cellular_component	proteasome complex
S	0001530	molecular_function	lipopolysaccharide binding
S	0002376	biological_process	immune system process
S	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
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S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
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S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0006915	biological_process	apoptotic process
S	0006974	biological_process	DNA damage response
S	0006979	biological_process	response to oxidative stress
S	0007283	biological_process	spermatogenesis
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S	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
S	0016604	cellular_component	nuclear body
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S	0030317	biological_process	flagellated sperm motility
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S	0032743	biological_process	positive regulation of interleukin-2 production
S	0032760	biological_process	positive regulation of tumor necrosis factor production
S	0034341	biological_process	response to type II interferon
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S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
S	0045061	biological_process	thymic T cell selection
S	0045063	biological_process	T-helper 1 cell differentiation
S	0045590	biological_process	negative regulation of regulatory T cell differentiation
S	0051321	biological_process	meiotic cell cycle
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0061136	biological_process	regulation of proteasomal protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	0071357	biological_process	cellular response to type I interferon
S	0072539	biological_process	T-helper 17 cell differentiation
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T	0000502	cellular_component	proteasome complex
T	0002376	biological_process	immune system process
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T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006281	biological_process	DNA repair
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0006915	biological_process	apoptotic process
T	0006974	biological_process	DNA damage response
T	0006979	biological_process	response to oxidative stress
T	0007283	biological_process	spermatogenesis
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T	0010498	biological_process	proteasomal protein catabolic process
T	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0030317	biological_process	flagellated sperm motility
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T	0032729	biological_process	positive regulation of type II interferon production
T	0032743	biological_process	positive regulation of interleukin-2 production
T	0032760	biological_process	positive regulation of tumor necrosis factor production
T	0034341	biological_process	response to type II interferon
T	0034515	cellular_component	proteasome storage granule
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
T	0045061	biological_process	thymic T cell selection
T	0045063	biological_process	T-helper 1 cell differentiation
T	0045590	biological_process	negative regulation of regulatory T cell differentiation
T	0051321	biological_process	meiotic cell cycle
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0061136	biological_process	regulation of proteasomal protein catabolic process
T	0070062	cellular_component	extracellular exosome
T	0071357	biological_process	cellular response to type I interferon
T	0072539	biological_process	T-helper 17 cell differentiation
T	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
T	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
U	0000502	cellular_component	proteasome complex
U	0000932	cellular_component	P-body
U	0002376	biological_process	immune system process
U	0003723	molecular_function	RNA binding
U	0004175	molecular_function	endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0005840	cellular_component	ribosome
U	0006281	biological_process	DNA repair
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0006915	biological_process	apoptotic process
U	0006974	biological_process	DNA damage response
U	0006979	biological_process	response to oxidative stress
U	0007283	biological_process	spermatogenesis
U	0008021	cellular_component	synaptic vesicle
U	0010498	biological_process	proteasomal protein catabolic process
U	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
U	0016363	cellular_component	nuclear matrix
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030016	cellular_component	myofibril
U	0030017	cellular_component	sarcomere
U	0030317	biological_process	flagellated sperm motility
U	0032729	biological_process	positive regulation of type II interferon production
U	0032743	biological_process	positive regulation of interleukin-2 production
U	0032760	biological_process	positive regulation of tumor necrosis factor production
U	0034341	biological_process	response to type II interferon
U	0034515	cellular_component	proteasome storage granule
U	0035639	molecular_function	purine ribonucleoside triphosphate binding
U	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
U	0045061	biological_process	thymic T cell selection
U	0045063	biological_process	T-helper 1 cell differentiation
U	0045590	biological_process	negative regulation of regulatory T cell differentiation
U	0050727	biological_process	regulation of inflammatory response
U	0051059	molecular_function	NF-kappaB binding
U	0051321	biological_process	meiotic cell cycle
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0061136	biological_process	regulation of proteasomal protein catabolic process
U	0070062	cellular_component	extracellular exosome
U	0071357	biological_process	cellular response to type I interferon
U	0072539	biological_process	T-helper 17 cell differentiation
U	0097229	cellular_component	sperm end piece
U	0097542	cellular_component	ciliary tip
U	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
U	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
V	0000502	cellular_component	proteasome complex
V	0004175	molecular_function	endopeptidase activity
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0006281	biological_process	DNA repair
V	0006508	biological_process	proteolysis
V	0006915	biological_process	apoptotic process
V	0006974	biological_process	DNA damage response
V	0006979	biological_process	response to oxidative stress
V	0007283	biological_process	spermatogenesis
V	0008021	cellular_component	synaptic vesicle
V	0008233	molecular_function	peptidase activity
V	0010498	biological_process	proteasomal protein catabolic process
V	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
V	0016604	cellular_component	nuclear body
V	0016787	molecular_function	hydrolase activity
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0030317	biological_process	flagellated sperm motility
V	0034515	cellular_component	proteasome storage granule
V	0034774	cellular_component	secretory granule lumen
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0051321	biological_process	meiotic cell cycle
V	0051603	biological_process	proteolysis involved in protein catabolic process
V	0061136	biological_process	regulation of proteasomal protein catabolic process
V	0071357	biological_process	cellular response to type I interferon
V	1904813	cellular_component	ficolin-1-rich granule lumen
V	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
W	0000502	cellular_component	proteasome complex
W	0002376	biological_process	immune system process
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0006281	biological_process	DNA repair
W	0006915	biological_process	apoptotic process
W	0006974	biological_process	DNA damage response
W	0006979	biological_process	response to oxidative stress
W	0007283	biological_process	spermatogenesis
W	0008021	cellular_component	synaptic vesicle
W	0010498	biological_process	proteasomal protein catabolic process
W	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0030317	biological_process	flagellated sperm motility
W	0032729	biological_process	positive regulation of type II interferon production
W	0032743	biological_process	positive regulation of interleukin-2 production
W	0032760	biological_process	positive regulation of tumor necrosis factor production
W	0034341	biological_process	response to type II interferon
W	0034515	cellular_component	proteasome storage granule
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
W	0045061	biological_process	thymic T cell selection
W	0045063	biological_process	T-helper 1 cell differentiation
W	0045590	biological_process	negative regulation of regulatory T cell differentiation
W	0051321	biological_process	meiotic cell cycle
W	0051603	biological_process	proteolysis involved in protein catabolic process
W	0061136	biological_process	regulation of proteasomal protein catabolic process
W	0070062	cellular_component	extracellular exosome
W	0071357	biological_process	cellular response to type I interferon
W	0072539	biological_process	T-helper 17 cell differentiation
W	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
W	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
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X	0002376	biological_process	immune system process
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X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
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X	0006281	biological_process	DNA repair
X	0006915	biological_process	apoptotic process
X	0006974	biological_process	DNA damage response
X	0006979	biological_process	response to oxidative stress
X	0007283	biological_process	spermatogenesis
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X	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
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X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0030317	biological_process	flagellated sperm motility
X	0032729	biological_process	positive regulation of type II interferon production
X	0032743	biological_process	positive regulation of interleukin-2 production
X	0032760	biological_process	positive regulation of tumor necrosis factor production
X	0034341	biological_process	response to type II interferon
X	0034515	cellular_component	proteasome storage granule
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
X	0045061	biological_process	thymic T cell selection
X	0045063	biological_process	T-helper 1 cell differentiation
X	0045590	biological_process	negative regulation of regulatory T cell differentiation
X	0051321	biological_process	meiotic cell cycle
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0061136	biological_process	regulation of proteasomal protein catabolic process
X	0070062	cellular_component	extracellular exosome
X	0071357	biological_process	cellular response to type I interferon
X	0072539	biological_process	T-helper 17 cell differentiation
X	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
X	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005839	cellular_component	proteasome core complex
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0000502	cellular_component	proteasome complex
Z	0002376	biological_process	immune system process
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Z	0005576	cellular_component	extracellular region
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0006281	biological_process	DNA repair
Z	0006915	biological_process	apoptotic process
Z	0006974	biological_process	DNA damage response
Z	0006979	biological_process	response to oxidative stress
Z	0007283	biological_process	spermatogenesis
Z	0008021	cellular_component	synaptic vesicle
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Z	0019774	cellular_component	proteasome core complex, beta-subunit complex
Z	0030317	biological_process	flagellated sperm motility
Z	0032729	biological_process	positive regulation of type II interferon production
Z	0032743	biological_process	positive regulation of interleukin-2 production
Z	0032760	biological_process	positive regulation of tumor necrosis factor production
Z	0034341	biological_process	response to type II interferon
Z	0034515	cellular_component	proteasome storage granule
Z	0034774	cellular_component	secretory granule lumen
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
Z	0045061	biological_process	thymic T cell selection
Z	0045063	biological_process	T-helper 1 cell differentiation
Z	0045590	biological_process	negative regulation of regulatory T cell differentiation
Z	0051321	biological_process	meiotic cell cycle
Z	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0061136	biological_process	regulation of proteasomal protein catabolic process
Z	0070062	cellular_component	extracellular exosome
Z	0071357	biological_process	cellular response to type I interferon
Z	0072539	biological_process	T-helper 17 cell differentiation
Z	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
Z	1904813	cellular_component	ficolin-1-rich granule lumen
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a	0000502	cellular_component	proteasome complex
a	0001530	molecular_function	lipopolysaccharide binding
a	0002376	biological_process	immune system process
a	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0006281	biological_process	DNA repair
a	0006915	biological_process	apoptotic process
a	0006974	biological_process	DNA damage response
a	0006979	biological_process	response to oxidative stress
a	0007283	biological_process	spermatogenesis
a	0008021	cellular_component	synaptic vesicle
a	0010498	biological_process	proteasomal protein catabolic process
a	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0030317	biological_process	flagellated sperm motility
a	0032729	biological_process	positive regulation of type II interferon production
a	0032743	biological_process	positive regulation of interleukin-2 production
a	0032760	biological_process	positive regulation of tumor necrosis factor production
a	0034341	biological_process	response to type II interferon
a	0034515	cellular_component	proteasome storage granule
a	0036064	cellular_component	ciliary basal body
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
a	0045061	biological_process	thymic T cell selection
a	0045063	biological_process	T-helper 1 cell differentiation
a	0045590	biological_process	negative regulation of regulatory T cell differentiation
a	0051321	biological_process	meiotic cell cycle
a	0051603	biological_process	proteolysis involved in protein catabolic process
a	0061136	biological_process	regulation of proteasomal protein catabolic process
a	0070062	cellular_component	extracellular exosome
a	0071357	biological_process	cellular response to type I interferon
a	0072539	biological_process	T-helper 17 cell differentiation
a	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
a	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
b	0000502	cellular_component	proteasome complex
b	0004175	molecular_function	endopeptidase activity
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0006281	biological_process	DNA repair
b	0006508	biological_process	proteolysis
b	0006915	biological_process	apoptotic process
b	0006974	biological_process	DNA damage response
b	0006979	biological_process	response to oxidative stress
b	0007283	biological_process	spermatogenesis
b	0008021	cellular_component	synaptic vesicle
b	0008233	molecular_function	peptidase activity
b	0010498	biological_process	proteasomal protein catabolic process
b	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
b	0016787	molecular_function	hydrolase activity
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0030317	biological_process	flagellated sperm motility
b	0034515	cellular_component	proteasome storage granule
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0045296	molecular_function	cadherin binding
b	0051321	biological_process	meiotic cell cycle
b	0051603	biological_process	proteolysis involved in protein catabolic process
b	0061136	biological_process	regulation of proteasomal protein catabolic process
b	0070062	cellular_component	extracellular exosome
b	0071357	biological_process	cellular response to type I interferon
b	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
c	0000166	molecular_function	nucleotide binding
c	0000502	cellular_component	proteasome complex
c	0000932	cellular_component	P-body
c	0001649	biological_process	osteoblast differentiation
c	0005515	molecular_function	protein binding
c	0005524	molecular_function	ATP binding
c	0005576	cellular_component	extracellular region
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0006979	biological_process	response to oxidative stress
c	0008021	cellular_component	synaptic vesicle
c	0008540	cellular_component	proteasome regulatory particle, base subcomplex
c	0010498	biological_process	proteasomal protein catabolic process
c	0016020	cellular_component	membrane
c	0016887	molecular_function	ATP hydrolysis activity
c	0022624	cellular_component	proteasome accessory complex
c	0034774	cellular_component	secretory granule lumen
c	0036402	molecular_function	proteasome-activating activity
c	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0061136	biological_process	regulation of proteasomal protein catabolic process
c	0071357	biological_process	cellular response to type I interferon
c	1901800	biological_process	positive regulation of proteasomal protein catabolic process
c	1904813	cellular_component	ficolin-1-rich granule lumen
d	0000166	molecular_function	nucleotide binding
d	0000502	cellular_component	proteasome complex
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005524	molecular_function	ATP binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005838	cellular_component	proteasome regulatory particle
d	0006979	biological_process	response to oxidative stress
d	0008021	cellular_component	synaptic vesicle
d	0008540	cellular_component	proteasome regulatory particle, base subcomplex
d	0010498	biological_process	proteasomal protein catabolic process
d	0016020	cellular_component	membrane
d	0016887	molecular_function	ATP hydrolysis activity
d	0022624	cellular_component	proteasome accessory complex
d	0036402	molecular_function	proteasome-activating activity
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0061136	biological_process	regulation of proteasomal protein catabolic process
d	0071357	biological_process	cellular response to type I interferon
e	0000166	molecular_function	nucleotide binding
e	0000502	cellular_component	proteasome complex
e	0005515	molecular_function	protein binding
e	0005524	molecular_function	ATP binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0006508	biological_process	proteolysis
e	0006979	biological_process	response to oxidative stress
e	0008021	cellular_component	synaptic vesicle
e	0008540	cellular_component	proteasome regulatory particle, base subcomplex
e	0010498	biological_process	proteasomal protein catabolic process
e	0016020	cellular_component	membrane
e	0016887	molecular_function	ATP hydrolysis activity
e	0022624	cellular_component	proteasome accessory complex
e	0036402	molecular_function	proteasome-activating activity
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0061136	biological_process	regulation of proteasomal protein catabolic process
e	0071357	biological_process	cellular response to type I interferon
f	0000166	molecular_function	nucleotide binding
f	0000502	cellular_component	proteasome complex
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006979	biological_process	response to oxidative stress
f	0008021	cellular_component	synaptic vesicle
f	0008540	cellular_component	proteasome regulatory particle, base subcomplex
f	0010498	biological_process	proteasomal protein catabolic process
f	0016020	cellular_component	membrane
f	0016234	cellular_component	inclusion body
f	0016887	molecular_function	ATP hydrolysis activity
f	0022624	cellular_component	proteasome accessory complex
f	0030674	molecular_function	protein-macromolecule adaptor activity
f	0031597	cellular_component	cytosolic proteasome complex
f	0036402	molecular_function	proteasome-activating activity
f	0036503	biological_process	ERAD pathway
f	0042802	molecular_function	identical protein binding
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
f	0061136	biological_process	regulation of proteasomal protein catabolic process
f	0070062	cellular_component	extracellular exosome
f	0071357	biological_process	cellular response to type I interferon
f	0090261	biological_process	positive regulation of inclusion body assembly
f	1901800	biological_process	positive regulation of proteasomal protein catabolic process
g	0000166	molecular_function	nucleotide binding
g	0000502	cellular_component	proteasome complex
g	0000932	cellular_component	P-body
g	0005515	molecular_function	protein binding
g	0005524	molecular_function	ATP binding
g	0005576	cellular_component	extracellular region
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006979	biological_process	response to oxidative stress
g	0008021	cellular_component	synaptic vesicle
g	0008540	cellular_component	proteasome regulatory particle, base subcomplex
g	0010498	biological_process	proteasomal protein catabolic process
g	0016020	cellular_component	membrane
g	0016887	molecular_function	ATP hydrolysis activity
g	0022624	cellular_component	proteasome accessory complex
g	0034774	cellular_component	secretory granule lumen
g	0036402	molecular_function	proteasome-activating activity
g	0042802	molecular_function	identical protein binding
g	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
g	0043921	biological_process	host-mediated perturbation of viral transcription
g	0045944	biological_process	positive regulation of transcription by RNA polymerase II
g	0061136	biological_process	regulation of proteasomal protein catabolic process
g	0071357	biological_process	cellular response to type I interferon
g	1901800	biological_process	positive regulation of proteasomal protein catabolic process
g	1904813	cellular_component	ficolin-1-rich granule lumen
h	0005524	molecular_function	ATP binding
h	0016887	molecular_function	ATP hydrolysis activity
i	0000502	cellular_component	proteasome complex
i	0005515	molecular_function	protein binding
i	0005576	cellular_component	extracellular region
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005829	cellular_component	cytosol
i	0005838	cellular_component	proteasome regulatory particle
i	0006979	biological_process	response to oxidative stress
i	0008021	cellular_component	synaptic vesicle
i	0008540	cellular_component	proteasome regulatory particle, base subcomplex
i	0010498	biological_process	proteasomal protein catabolic process
i	0016020	cellular_component	membrane
i	0022624	cellular_component	proteasome accessory complex
i	0030234	molecular_function	enzyme regulator activity
i	0031625	molecular_function	ubiquitin protein ligase binding
i	0034515	cellular_component	proteasome storage granule
i	0035578	cellular_component	azurophil granule lumen
i	0042176	biological_process	regulation of protein catabolic process
i	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
i	0061136	biological_process	regulation of proteasomal protein catabolic process
i	0071357	biological_process	cellular response to type I interferon
j	0000502	cellular_component	proteasome complex
j	0005515	molecular_function	protein binding
j	0005576	cellular_component	extracellular region
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005829	cellular_component	cytosol
j	0005838	cellular_component	proteasome regulatory particle
j	0006511	biological_process	ubiquitin-dependent protein catabolic process
j	0006979	biological_process	response to oxidative stress
j	0008021	cellular_component	synaptic vesicle
j	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
j	0010498	biological_process	proteasomal protein catabolic process
j	0016020	cellular_component	membrane
j	0022624	cellular_component	proteasome accessory complex
j	0030234	molecular_function	enzyme regulator activity
j	0034774	cellular_component	secretory granule lumen
j	0042176	biological_process	regulation of protein catabolic process
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0061136	biological_process	regulation of proteasomal protein catabolic process
j	0070062	cellular_component	extracellular exosome
j	0071357	biological_process	cellular response to type I interferon
j	1904813	cellular_component	ficolin-1-rich granule lumen
k	0000502	cellular_component	proteasome complex
k	0005515	molecular_function	protein binding
k	0005576	cellular_component	extracellular region
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0005838	cellular_component	proteasome regulatory particle
k	0006979	biological_process	response to oxidative stress
k	0008021	cellular_component	synaptic vesicle
k	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
k	0010498	biological_process	proteasomal protein catabolic process
k	0016020	cellular_component	membrane
k	0022624	cellular_component	proteasome accessory complex
k	0034774	cellular_component	secretory granule lumen
k	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
k	0061136	biological_process	regulation of proteasomal protein catabolic process
k	0070062	cellular_component	extracellular exosome
k	0071357	biological_process	cellular response to type I interferon
k	1904813	cellular_component	ficolin-1-rich granule lumen
l	0000502	cellular_component	proteasome complex
l	0005198	molecular_function	structural molecule activity
l	0005515	molecular_function	protein binding
l	0005576	cellular_component	extracellular region
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005829	cellular_component	cytosol
l	0005838	cellular_component	proteasome regulatory particle
l	0006511	biological_process	ubiquitin-dependent protein catabolic process
l	0006979	biological_process	response to oxidative stress
l	0008021	cellular_component	synaptic vesicle
l	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
l	0010498	biological_process	proteasomal protein catabolic process
l	0016020	cellular_component	membrane
l	0022624	cellular_component	proteasome accessory complex
l	0032991	cellular_component	protein-containing complex
l	0034774	cellular_component	secretory granule lumen
l	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
l	0043248	biological_process	proteasome assembly
l	0048863	biological_process	stem cell differentiation
l	0061136	biological_process	regulation of proteasomal protein catabolic process
l	0071357	biological_process	cellular response to type I interferon
l	1904813	cellular_component	ficolin-1-rich granule lumen
m	0000502	cellular_component	proteasome complex
m	0005515	molecular_function	protein binding
m	0005576	cellular_component	extracellular region
m	0005654	cellular_component	nucleoplasm
m	0005829	cellular_component	cytosol
m	0005838	cellular_component	proteasome regulatory particle
m	0006979	biological_process	response to oxidative stress
m	0008021	cellular_component	synaptic vesicle
m	0010498	biological_process	proteasomal protein catabolic process
m	0022624	cellular_component	proteasome accessory complex
m	0032991	cellular_component	protein-containing complex
m	0034774	cellular_component	secretory granule lumen
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
m	0061136	biological_process	regulation of proteasomal protein catabolic process
m	0071357	biological_process	cellular response to type I interferon
m	1904813	cellular_component	ficolin-1-rich granule lumen
n	0000502	cellular_component	proteasome complex
n	0005515	molecular_function	protein binding
n	0005576	cellular_component	extracellular region
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005829	cellular_component	cytosol
n	0005838	cellular_component	proteasome regulatory particle
n	0006979	biological_process	response to oxidative stress
n	0008021	cellular_component	synaptic vesicle
n	0008233	molecular_function	peptidase activity
n	0008237	molecular_function	metallopeptidase activity
n	0010498	biological_process	proteasomal protein catabolic process
n	0016020	cellular_component	membrane
n	0034774	cellular_component	secretory granule lumen
n	0042803	molecular_function	protein homodimerization activity
n	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
n	0061136	biological_process	regulation of proteasomal protein catabolic process
n	0070062	cellular_component	extracellular exosome
n	0071357	biological_process	cellular response to type I interferon
n	0140492	molecular_function	metal-dependent deubiquitinase activity
n	1904813	cellular_component	ficolin-1-rich granule lumen
o	0000502	cellular_component	proteasome complex
o	0005198	molecular_function	structural molecule activity
o	0005515	molecular_function	protein binding
o	0005576	cellular_component	extracellular region
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005829	cellular_component	cytosol
o	0005838	cellular_component	proteasome regulatory particle
o	0006511	biological_process	ubiquitin-dependent protein catabolic process
o	0006979	biological_process	response to oxidative stress
o	0008021	cellular_component	synaptic vesicle
o	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
o	0010498	biological_process	proteasomal protein catabolic process
o	0016020	cellular_component	membrane
o	0022624	cellular_component	proteasome accessory complex
o	0034774	cellular_component	secretory granule lumen
o	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
o	0061136	biological_process	regulation of proteasomal protein catabolic process
o	0071357	biological_process	cellular response to type I interferon
o	1904813	cellular_component	ficolin-1-rich granule lumen
p	0000502	cellular_component	proteasome complex
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005829	cellular_component	cytosol
p	0006979	biological_process	response to oxidative stress
p	0008021	cellular_component	synaptic vesicle
p	0008540	cellular_component	proteasome regulatory particle, base subcomplex
p	0010498	biological_process	proteasomal protein catabolic process
p	0022624	cellular_component	proteasome accessory complex
p	0031593	molecular_function	polyubiquitin modification-dependent protein binding
p	0042802	molecular_function	identical protein binding
p	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
p	0060090	molecular_function	molecular adaptor activity
p	0061136	biological_process	regulation of proteasomal protein catabolic process
p	0071357	biological_process	cellular response to type I interferon
q	0000502	cellular_component	proteasome complex
q	0000724	biological_process	double-strand break repair via homologous recombination
q	0004843	molecular_function	cysteine-type deubiquitinase activity
q	0005515	molecular_function	protein binding
q	0005576	cellular_component	extracellular region
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005829	cellular_component	cytosol
q	0006281	biological_process	DNA repair
q	0006303	biological_process	double-strand break repair via nonhomologous end joining
q	0006508	biological_process	proteolysis
q	0006511	biological_process	ubiquitin-dependent protein catabolic process
q	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
q	0006914	biological_process	autophagy
q	0006974	biological_process	DNA damage response
q	0006979	biological_process	response to oxidative stress
q	0008021	cellular_component	synaptic vesicle
q	0008233	molecular_function	peptidase activity
q	0008234	molecular_function	cysteine-type peptidase activity
q	0008237	molecular_function	metallopeptidase activity
q	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
q	0010498	biological_process	proteasomal protein catabolic process
q	0016192	biological_process	vesicle-mediated transport
q	0016241	biological_process	regulation of macroautophagy
q	0016579	biological_process	protein deubiquitination
q	0016787	molecular_function	hydrolase activity
q	0022624	cellular_component	proteasome accessory complex
q	0031597	cellular_component	cytosolic proteasome complex
q	0034774	cellular_component	secretory granule lumen
q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
q	0045471	biological_process	response to ethanol
q	0046872	molecular_function	metal ion binding
q	0061133	molecular_function	endopeptidase activator activity
q	0061136	biological_process	regulation of proteasomal protein catabolic process
q	0061578	molecular_function	K63-linked deubiquitinase activity
q	0070536	biological_process	protein K63-linked deubiquitination
q	0070628	molecular_function	proteasome binding
q	0071357	biological_process	cellular response to type I interferon
q	0140492	molecular_function	metal-dependent deubiquitinase activity
q	1904813	cellular_component	ficolin-1-rich granule lumen
r	0000502	cellular_component	proteasome complex
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005829	cellular_component	cytosol
r	0005838	cellular_component	proteasome regulatory particle
r	0006508	biological_process	proteolysis
r	0006979	biological_process	response to oxidative stress
r	0008021	cellular_component	synaptic vesicle
r	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
r	0010498	biological_process	proteasomal protein catabolic process
r	0022624	cellular_component	proteasome accessory complex
r	0032991	cellular_component	protein-containing complex
r	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
r	0061136	biological_process	regulation of proteasomal protein catabolic process
r	0071357	biological_process	cellular response to type I interferon
s	0000502	cellular_component	proteasome complex
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005829	cellular_component	cytosol
s	0006406	biological_process	mRNA export from nucleus
s	0006979	biological_process	response to oxidative stress
s	0008021	cellular_component	synaptic vesicle
s	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
s	0010498	biological_process	proteasomal protein catabolic process
s	0032039	cellular_component	integrator complex
s	0032991	cellular_component	protein-containing complex
s	0043130	molecular_function	ubiquitin binding
s	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
s	0043248	biological_process	proteasome assembly
s	0045944	biological_process	positive regulation of transcription by RNA polymerase II
s	0061136	biological_process	regulation of proteasomal protein catabolic process
s	0071357	biological_process	cellular response to type I interferon

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ADP c 501

Chain	Residue
c	ASP176
c	ILE354
c	GLY382
c	ALA383
c	ARG386
d	ARG343
d	ARG346
c	VAL177
c	GLY178
c	GLY179
c	GLY219
c	THR220
c	GLY221
c	LYS222
c	THR223

---

site_id	AC2
Number of Residues	12
Details	binding site for residue ADP d 501

Chain	Residue
d	ASP186
d	ILE187
d	GLY229
d	GLY231
d	LYS232
d	THR233
d	LEU234
d	ILE364
d	GLY392
d	LYS396
h	ARG307
h	ARG310

---

site_id	AC3
Number of Residues	12
Details	binding site for residue ADP e 501

Chain	Residue
e	ILE167
e	GLY168
e	MET170
e	GLY209
e	CYS210
e	GLY211
e	LYS212
e	THR213
e	MET214
e	GLY372
e	ALA373
f	ARG291

---

site_id	AC4
Number of Residues	13
Details	binding site for residue ADP g 501

Chain	Residue
f	GLY136
f	LEU138
f	GLY177
f	THR178
f	GLY179
f	LYS180
f	THR181
f	LEU182
f	ILE312
f	HIS316
f	ARG344
g	ARG344
g	ARG347

---

site_id	AC5
Number of Residues	13
Details	binding site for residue ADP g 502

Chain	Residue
g	ASP187
g	ILE188
g	GLY189
g	THR231
g	GLY232
g	LYS233
g	THR234
g	LEU235
g	ASN333
g	ILE365
g	HIS369
g	GLY393
g	LYS397

---

site_id	AC6
Number of Residues	14
Details	binding site for residue ADP h 401

Chain	Residue
h	MET150
h	ILE151
h	GLY152
h	PRO192
h	GLY193
h	THR194
h	GLY195
h	LYS196
h	THR197
h	GLU250
h	ILE328
h	HIS332
h	GLY356
h	LYS360

---

site_id	AC7
Number of Residues	14
Details	binding site for Ligand residues 6VA t 4 through 6V9 t 1 bound to THR K 1

Chain	Residue
K	THR1
K	ARG19
K	ALA20
K	THR21
K	VAL31
K	MET45
K	ALA46
K	GLY47
K	ALA49
K	CYS52
K	SER130
K	TYR169
L	ASP125
L	VAL127

---

site_id	AC8
Number of Residues	13
Details	binding site for Ligand 6VA t 4 bound to THR K 1

Chain	Residue
K	ALA46
K	GLY47
K	ALA49
K	CYS52
K	SER130
K	TYR169
t	7C93
K	THR1
K	ARG19
K	ALA20
K	THR21
K	VAL31
K	MET45

---

site_id	AC9
Number of Residues	13
Details	binding site for Ligand residues 6VA u 4 through 6V9 u 1 bound to THR Y 1

Chain	Residue
Y	THR1
Y	ARG19
Y	ALA20
Y	THR21
Y	VAL31
Y	MET45
Y	ALA46
Y	GLY47
Y	ALA49
Y	CYS52
Y	SER130
Y	TYR169
Z	ASP125

---

site_id	AD1
Number of Residues	13
Details	binding site for Ligand 6VA u 4 bound to THR Y 1

Chain	Residue
Y	THR1
Y	ARG19
Y	ALA20
Y	THR21
Y	VAL31
Y	MET45
Y	ALA46
Y	GLY47
Y	ALA49
Y	CYS52
Y	SER130
Y	TYR169
u	7C93

---

site_id	AD2
Number of Residues	4
Details	binding site for Ligand VAL m 205 bound to THR m 204

Chain	Residue
h	ARG340
m	THR204
m	SER206
m	GLU245

---

site_id	AD3
Number of Residues	13
Details	binding site for Ligand residues MET m 214 through PHE m 208 bound to SER m 206

Chain	Residue
h	ARG340
m	VAL182
m	SER206
m	THR207
m	THR209
m	SER210
m	TYR211
m	GLU212
m	LEU213
m	ASP215
m	TYR216
m	THR218
m	PHE219

---

site_id	AD4
Number of Residues	9
Details	binding site for Di-peptide ASP i 504 and THR i 508

Chain	Residue
i	ASN500
i	LEU501
i	GLN503
i	ASP505
i	ALA506
i	VAL507
i	GLY509
i	GLU510
i	ALA512

---

site_id	AD5
Number of Residues	9
Details	binding site for Di-peptide ASP i 504 and THR i 508

Chain	Residue
i	ASN500
i	LEU501
i	GLN503
i	ASP505
i	ALA506
i	VAL507
i	GLY509
i	GLU510
i	ALA512

---

site_id	AD6
Number of Residues	8
Details	binding site for Di-peptide LEU i 521 and TYR i 557

Chain	Residue
i	VAL519
i	MET520
i	GLY522
i	ALA553
i	LEU554
i	VAL555
i	MET556
i	GLY558

---

site_id	AD7
Number of Residues	9
Details	binding site for Di-peptide GLY i 522 and GLY i 558

Chain	Residue
i	MET520
i	LEU521
i	SER523
i	LYS524
i	LEU554
i	VAL555
i	MET556
i	TYR557
i	ARG559

---

site_id	AD8
Number of Residues	15
Details	binding site for Di-peptide LEU i 548 and SER i 581

Chain	Residue
i	ILE544
i	LEU545
i	GLY547
i	ALA549
i	VAL550
i	ILE552
i	LEU570
i	ILE577
i	LEU578
i	ARG579
i	ARG580
i	GLY582
i	MET583
i	TYR584
i	THR585

---

site_id	AD9
Number of Residues	12
Details	binding site for Di-peptide LEU l 153 and LEU l 157

Chain	Residue
l	GLU130
l	LEU149
l	GLY150
l	SER151
l	GLN152
l	LEU154
l	ARG155
l	GLU156
l	LYS158
l	LYS159
l	MET160
l	ASP161

---

site_id	AE1
Number of Residues	10
Details	binding site for Di-peptide ASP l 243 and LYS l 246

Chain	Residue
l	PHE236
l	TYR239
l	SER241
l	ILE242
l	SER244
l	PRO245
l	ALA247
l	ILE248
l	THR249
l	SER250

---

site_id	AE2
Number of Residues	9
Details	binding site for Di-peptide LEU m 134 and GLU m 169

Chain	Residue
m	ALA133
m	GLY135
m	HIS136
m	ARG137
m	LEU138
m	LEU167
m	ILE168
m	GLU170
m	GLY171

---

site_id	AE3
Number of Residues	9
Details	binding site for Di-peptide LEU m 134 and GLU m 169

Chain	Residue
m	ALA133
m	GLY135
m	HIS136
m	ARG137
m	LEU138
m	LEU167
m	ILE168
m	GLU170
m	GLY171

---

site_id	AE4
Number of Residues	9
Details	binding site for Di-peptide LEU m 134 and GLU m 169

Chain	Residue
m	ALA133
m	GLY135
m	HIS136
m	ARG137
m	LEU138
m	LEU167
m	ILE168
m	GLU170
m	GLY171

---

site_id	AE5
Number of Residues	9
Details	binding site for Di-peptide ALA m 198 and LEU m 202

Chain	Residue
m	GLN196
m	ALA197
m	GLU199
m	LEU200
m	PHE201
m	ASP203
m	THR204
m	VAL226
m	LEU231

---

site_id	AE6
Number of Residues	9
Details	binding site for Di-peptide GLU m 199 and LEU m 202

Chain	Residue
m	LYS195
m	GLN196
m	ALA197
m	ALA198
m	LEU200
m	PHE201
m	ASP203
m	THR204
m	LEU231

---

site_id	AE7
Number of Residues	21
Details	binding site for Di-peptide TYR n 250 and ARG j 321

Chain	Residue
j	ILE246
j	ILE247
j	ARG248
j	LEU249
j	HIS251
j	ASN252
j	VAL253
j	ILE254
j	SER319
j	THR320
j	GLU322
j	PRO323
j	LEU325
n	VAL246
n	LYS247
n	ALA248
n	PHE249
n	LEU251
n	LYS252
n	THR253
n	ASN254

---

site_id	AE8
Number of Residues	17
Details	binding site for Di-peptide LEU n 251 and THR j 320

Chain	Residue
j	ILE247
j	ARG248
j	LEU249
j	ARG250
j	ASN252
j	VAL253
j	LYS255
j	SER319
j	ARG321
n	LYS247
n	ALA248
n	PHE249
n	TYR250
n	LYS252
n	THR253
n	ASN254
n	ASP255

---

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV

Chain	Residue	Details
r	ALA-6-VAL9

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. FdrhiTiFSPeGRlyQVEYAfkA

Chain	Residue	Details
G	PHE9-ALA31
B	TYR5-ALA27
D	TYR8-ALA30
E	TYR6-ALA28
A	TYR5-ALA27
C	TYR3-ALA25
Q	TYR3-ALA25
S	TYR6-ALA28
F	TYR7-ALA29

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. IkVImATNridiLDsALl.R

Chain	Residue	Details
h	ILE289-ARG307
e	VAL305-ARG323
g	VAL326-ARG344
c	ILE315-ARG333
f	VAL273-ARG291
d	VAL325-ARG343

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. IGIqGpdYVLVASDrvaasnivqmkddhd.KmfkmsekilllcvGeaGD

Chain	Residue	Details
J	ILE5-ASP52
L	LEU13-ASP60
a	LEU12-ASP59
K	LEU4-ASP51
B	LEU35-ASP82
I	MET11-ASP58
b	MET4-ASP51
H	ALA4-ASP51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	33
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	9
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"17370265","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	34
Details	Repeat: {"description":"PC 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	33
Details	Repeat: {"description":"PC 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	35
Details	Repeat: {"description":"PC 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	32
Details	Repeat: {"description":"PC 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	34
Details	Repeat: {"description":"PC 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	336
Details	Domain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2004","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Potts A.","Brablan J.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	135
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	13
Details	Motif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17693683","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---