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5M32

Human 26S proteasome in complex with Oprozomib

Functional Information from GO Data
ChainGOidnamespacecontents
A0000502cellular_componentproteasome complex
A0000932cellular_componentP-body
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005839cellular_componentproteasome core complex
A0006511biological_processubiquitin-dependent protein catabolic process
A0009615biological_processresponse to virus
A0010498biological_processproteasomal protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0034774cellular_componentsecretory granule lumen
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051603biological_processproteolysis involved in protein catabolic process
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
B0000502cellular_componentproteasome complex
B0000932cellular_componentP-body
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005839cellular_componentproteasome core complex
B0006511biological_processubiquitin-dependent protein catabolic process
B0010498biological_processproteasomal protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0051603biological_processproteolysis involved in protein catabolic process
B0070062cellular_componentextracellular exosome
C0000502cellular_componentproteasome complex
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0010498biological_processproteasomal protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0042802molecular_functionidentical protein binding
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
C0070062cellular_componentextracellular exosome
C0098794cellular_componentpostsynapse
D0000502cellular_componentproteasome complex
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0010498biological_processproteasomal protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0034774cellular_componentsecretory granule lumen
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
D0070062cellular_componentextracellular exosome
D1904813cellular_componentficolin-1-rich granule lumen
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0010498biological_processproteasomal protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0031625molecular_functionubiquitin protein ligase binding
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0045202cellular_componentsynapse
F0051603biological_processproteolysis involved in protein catabolic process
F0052548biological_processregulation of endopeptidase activity
F0070062cellular_componentextracellular exosome
G0000502cellular_componentproteasome complex
G0000932cellular_componentP-body
G0003723molecular_functionRNA binding
G0004175molecular_functionendopeptidase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005839cellular_componentproteasome core complex
G0005840cellular_componentribosome
G0006511biological_processubiquitin-dependent protein catabolic process
G0010498biological_processproteasomal protein catabolic process
G0016363cellular_componentnuclear matrix
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0030016cellular_componentmyofibril
G0030017cellular_componentsarcomere
G0035639molecular_functionpurine ribonucleoside triphosphate binding
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0050727biological_processregulation of inflammatory response
G0051059molecular_functionNF-kappaB binding
G0051092biological_processpositive regulation of NF-kappaB transcription factor activity
G0051603biological_processproteolysis involved in protein catabolic process
G0070062cellular_componentextracellular exosome
H0000502cellular_componentproteasome complex
H0004175molecular_functionendopeptidase activity
H0004298molecular_functionthreonine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005839cellular_componentproteasome core complex
H0006508biological_processproteolysis
H0008233molecular_functionpeptidase activity
H0016604cellular_componentnuclear body
H0016787molecular_functionhydrolase activity
H0019774cellular_componentproteasome core complex, beta-subunit complex
H0034774cellular_componentsecretory granule lumen
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0051603biological_processproteolysis involved in protein catabolic process
H1904813cellular_componentficolin-1-rich granule lumen
I0000502cellular_componentproteasome complex
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005839cellular_componentproteasome core complex
I0019774cellular_componentproteasome core complex, beta-subunit complex
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0051603biological_processproteolysis involved in protein catabolic process
I0070062cellular_componentextracellular exosome
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005839cellular_componentproteasome core complex
J0010243biological_processresponse to organonitrogen compound
J0010498biological_processproteasomal protein catabolic process
J0014070biological_processresponse to organic cyclic compound
J0016020cellular_componentmembrane
J0019774cellular_componentproteasome core complex, beta-subunit complex
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0051603biological_processproteolysis involved in protein catabolic process
J0070062cellular_componentextracellular exosome
K0004298molecular_functionthreonine-type endopeptidase activity
K0005839cellular_componentproteasome core complex
K0051603biological_processproteolysis involved in protein catabolic process
L0000502cellular_componentproteasome complex
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0005839cellular_componentproteasome core complex
L0019774cellular_componentproteasome core complex, beta-subunit complex
L0034774cellular_componentsecretory granule lumen
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0051603biological_processproteolysis involved in protein catabolic process
L0070062cellular_componentextracellular exosome
L1904813cellular_componentficolin-1-rich granule lumen
M0000502cellular_componentproteasome complex
M0001530molecular_functionlipopolysaccharide binding
M0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005829cellular_componentcytosol
M0005839cellular_componentproteasome core complex
M0019774cellular_componentproteasome core complex, beta-subunit complex
M0036064cellular_componentciliary basal body
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0051603biological_processproteolysis involved in protein catabolic process
M0070062cellular_componentextracellular exosome
N0000502cellular_componentproteasome complex
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005739cellular_componentmitochondrion
N0005829cellular_componentcytosol
N0005839cellular_componentproteasome core complex
N0006508biological_processproteolysis
N0008233molecular_functionpeptidase activity
N0016787molecular_functionhydrolase activity
N0019774cellular_componentproteasome core complex, beta-subunit complex
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0045296molecular_functioncadherin binding
N0051603biological_processproteolysis involved in protein catabolic process
N0070062cellular_componentextracellular exosome
O0000502cellular_componentproteasome complex
O0000932cellular_componentP-body
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005839cellular_componentproteasome core complex
O0006511biological_processubiquitin-dependent protein catabolic process
O0009615biological_processresponse to virus
O0010498biological_processproteasomal protein catabolic process
O0019773cellular_componentproteasome core complex, alpha-subunit complex
O0034774cellular_componentsecretory granule lumen
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0051603biological_processproteolysis involved in protein catabolic process
O0070062cellular_componentextracellular exosome
O1904813cellular_componentficolin-1-rich granule lumen
P0000502cellular_componentproteasome complex
P0000932cellular_componentP-body
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005839cellular_componentproteasome core complex
P0006511biological_processubiquitin-dependent protein catabolic process
P0010498biological_processproteasomal protein catabolic process
P0019773cellular_componentproteasome core complex, alpha-subunit complex
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0043231cellular_componentintracellular membrane-bounded organelle
P0051603biological_processproteolysis involved in protein catabolic process
P0070062cellular_componentextracellular exosome
Q0000502cellular_componentproteasome complex
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0005839cellular_componentproteasome core complex
Q0006511biological_processubiquitin-dependent protein catabolic process
Q0010498biological_processproteasomal protein catabolic process
Q0019773cellular_componentproteasome core complex, alpha-subunit complex
Q0042802molecular_functionidentical protein binding
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0051603biological_processproteolysis involved in protein catabolic process
Q0070062cellular_componentextracellular exosome
Q0098794cellular_componentpostsynapse
R0000502cellular_componentproteasome complex
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0005839cellular_componentproteasome core complex
R0006511biological_processubiquitin-dependent protein catabolic process
R0010498biological_processproteasomal protein catabolic process
R0019773cellular_componentproteasome core complex, alpha-subunit complex
R0034774cellular_componentsecretory granule lumen
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0051603biological_processproteolysis involved in protein catabolic process
R0070062cellular_componentextracellular exosome
R1904813cellular_componentficolin-1-rich granule lumen
S0000502cellular_componentproteasome complex
S0001530molecular_functionlipopolysaccharide binding
S0002376biological_processimmune system process
S0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005737cellular_componentcytoplasm
S0005813cellular_componentcentrosome
S0005829cellular_componentcytosol
S0005839cellular_componentproteasome core complex
S0006511biological_processubiquitin-dependent protein catabolic process
S0010498biological_processproteasomal protein catabolic process
S0019773cellular_componentproteasome core complex, alpha-subunit complex
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0051603biological_processproteolysis involved in protein catabolic process
S0070062cellular_componentextracellular exosome
T0000502cellular_componentproteasome complex
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005654cellular_componentnucleoplasm
T0005737cellular_componentcytoplasm
T0005829cellular_componentcytosol
T0005839cellular_componentproteasome core complex
T0006511biological_processubiquitin-dependent protein catabolic process
T0010498biological_processproteasomal protein catabolic process
T0019773cellular_componentproteasome core complex, alpha-subunit complex
T0031625molecular_functionubiquitin protein ligase binding
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0045202cellular_componentsynapse
T0051603biological_processproteolysis involved in protein catabolic process
T0052548biological_processregulation of endopeptidase activity
T0070062cellular_componentextracellular exosome
U0000502cellular_componentproteasome complex
U0000932cellular_componentP-body
U0003723molecular_functionRNA binding
U0004175molecular_functionendopeptidase activity
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005737cellular_componentcytoplasm
U0005829cellular_componentcytosol
U0005839cellular_componentproteasome core complex
U0005840cellular_componentribosome
U0006511biological_processubiquitin-dependent protein catabolic process
U0010498biological_processproteasomal protein catabolic process
U0016363cellular_componentnuclear matrix
U0019773cellular_componentproteasome core complex, alpha-subunit complex
U0030016cellular_componentmyofibril
U0030017cellular_componentsarcomere
U0035639molecular_functionpurine ribonucleoside triphosphate binding
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0050727biological_processregulation of inflammatory response
U0051059molecular_functionNF-kappaB binding
U0051092biological_processpositive regulation of NF-kappaB transcription factor activity
U0051603biological_processproteolysis involved in protein catabolic process
U0070062cellular_componentextracellular exosome
V0000502cellular_componentproteasome complex
V0004175molecular_functionendopeptidase activity
V0004298molecular_functionthreonine-type endopeptidase activity
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005737cellular_componentcytoplasm
V0005829cellular_componentcytosol
V0005839cellular_componentproteasome core complex
V0006508biological_processproteolysis
V0008233molecular_functionpeptidase activity
V0016604cellular_componentnuclear body
V0016787molecular_functionhydrolase activity
V0019774cellular_componentproteasome core complex, beta-subunit complex
V0034774cellular_componentsecretory granule lumen
V0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0051603biological_processproteolysis involved in protein catabolic process
V1904813cellular_componentficolin-1-rich granule lumen
W0000502cellular_componentproteasome complex
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005737cellular_componentcytoplasm
W0005829cellular_componentcytosol
W0005839cellular_componentproteasome core complex
W0019774cellular_componentproteasome core complex, beta-subunit complex
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0051603biological_processproteolysis involved in protein catabolic process
W0070062cellular_componentextracellular exosome
X0000502cellular_componentproteasome complex
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0005839cellular_componentproteasome core complex
X0010243biological_processresponse to organonitrogen compound
X0010498biological_processproteasomal protein catabolic process
X0014070biological_processresponse to organic cyclic compound
X0016020cellular_componentmembrane
X0019774cellular_componentproteasome core complex, beta-subunit complex
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0051603biological_processproteolysis involved in protein catabolic process
X0070062cellular_componentextracellular exosome
Y0004298molecular_functionthreonine-type endopeptidase activity
Y0005839cellular_componentproteasome core complex
Y0051603biological_processproteolysis involved in protein catabolic process
Z0000502cellular_componentproteasome complex
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0005737cellular_componentcytoplasm
Z0005829cellular_componentcytosol
Z0005839cellular_componentproteasome core complex
Z0019774cellular_componentproteasome core complex, beta-subunit complex
Z0034774cellular_componentsecretory granule lumen
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0051603biological_processproteolysis involved in protein catabolic process
Z0070062cellular_componentextracellular exosome
Z1904813cellular_componentficolin-1-rich granule lumen
a0000502cellular_componentproteasome complex
a0001530molecular_functionlipopolysaccharide binding
a0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005737cellular_componentcytoplasm
a0005739cellular_componentmitochondrion
a0005829cellular_componentcytosol
a0005839cellular_componentproteasome core complex
a0019774cellular_componentproteasome core complex, beta-subunit complex
a0036064cellular_componentciliary basal body
a0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
a0051603biological_processproteolysis involved in protein catabolic process
a0070062cellular_componentextracellular exosome
b0000502cellular_componentproteasome complex
b0004175molecular_functionendopeptidase activity
b0004298molecular_functionthreonine-type endopeptidase activity
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005737cellular_componentcytoplasm
b0005739cellular_componentmitochondrion
b0005829cellular_componentcytosol
b0005839cellular_componentproteasome core complex
b0006508biological_processproteolysis
b0008233molecular_functionpeptidase activity
b0016787molecular_functionhydrolase activity
b0019774cellular_componentproteasome core complex, beta-subunit complex
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0045296molecular_functioncadherin binding
b0051603biological_processproteolysis involved in protein catabolic process
b0070062cellular_componentextracellular exosome
c0000166molecular_functionnucleotide binding
c0000502cellular_componentproteasome complex
c0000932cellular_componentP-body
c0001649biological_processosteoblast differentiation
c0005515molecular_functionprotein binding
c0005524molecular_functionATP binding
c0005576cellular_componentextracellular region
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005737cellular_componentcytoplasm
c0005829cellular_componentcytosol
c0006511biological_processubiquitin-dependent protein catabolic process
c0008540cellular_componentproteasome regulatory particle, base subcomplex
c0016020cellular_componentmembrane
c0016887molecular_functionATP hydrolysis activity
c0022624cellular_componentproteasome accessory complex
c0034774cellular_componentsecretory granule lumen
c0036402molecular_functionproteasome-activating activity
c0036464cellular_componentcytoplasmic ribonucleoprotein granule
c0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
c1901800biological_processpositive regulation of proteasomal protein catabolic process
c1904813cellular_componentficolin-1-rich granule lumen
d0000166molecular_functionnucleotide binding
d0000502cellular_componentproteasome complex
d0003723molecular_functionRNA binding
d0005515molecular_functionprotein binding
d0005524molecular_functionATP binding
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005737cellular_componentcytoplasm
d0005829cellular_componentcytosol
d0005838cellular_componentproteasome regulatory particle
d0008540cellular_componentproteasome regulatory particle, base subcomplex
d0016020cellular_componentmembrane
d0016887molecular_functionATP hydrolysis activity
d0022624cellular_componentproteasome accessory complex
d0036402molecular_functionproteasome-activating activity
d0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
d1901800biological_processpositive regulation of proteasomal protein catabolic process
e0000166molecular_functionnucleotide binding
e0000502cellular_componentproteasome complex
e0001824biological_processblastocyst development
e0005515molecular_functionprotein binding
e0005524molecular_functionATP binding
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005737cellular_componentcytoplasm
e0005829cellular_componentcytosol
e0006508biological_processproteolysis
e0008540cellular_componentproteasome regulatory particle, base subcomplex
e0016020cellular_componentmembrane
e0016234cellular_componentinclusion body
e0016887molecular_functionATP hydrolysis activity
e0022624cellular_componentproteasome accessory complex
e0031597cellular_componentcytosolic proteasome complex
e0036402molecular_functionproteasome-activating activity
e0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
e0045202cellular_componentsynapse
e1901800biological_processpositive regulation of proteasomal protein catabolic process
f0000166molecular_functionnucleotide binding
f0000502cellular_componentproteasome complex
f0005515molecular_functionprotein binding
f0005524molecular_functionATP binding
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005737cellular_componentcytoplasm
f0005829cellular_componentcytosol
f0008540cellular_componentproteasome regulatory particle, base subcomplex
f0016020cellular_componentmembrane
f0016234cellular_componentinclusion body
f0016887molecular_functionATP hydrolysis activity
f0022624cellular_componentproteasome accessory complex
f0030674molecular_functionprotein-macromolecule adaptor activity
f0031597cellular_componentcytosolic proteasome complex
f0036402molecular_functionproteasome-activating activity
f0036503biological_processERAD pathway
f0042802molecular_functionidentical protein binding
f0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
f0070062cellular_componentextracellular exosome
f0090261biological_processpositive regulation of inclusion body assembly
f1901800biological_processpositive regulation of proteasomal protein catabolic process
g0000166molecular_functionnucleotide binding
g0000502cellular_componentproteasome complex
g0000932cellular_componentP-body
g0005515molecular_functionprotein binding
g0005524molecular_functionATP binding
g0005576cellular_componentextracellular region
g0005634cellular_componentnucleus
g0005654cellular_componentnucleoplasm
g0005737cellular_componentcytoplasm
g0005829cellular_componentcytosol
g0008540cellular_componentproteasome regulatory particle, base subcomplex
g0016020cellular_componentmembrane
g0016887molecular_functionATP hydrolysis activity
g0022624cellular_componentproteasome accessory complex
g0034774cellular_componentsecretory granule lumen
g0036402molecular_functionproteasome-activating activity
g0042802molecular_functionidentical protein binding
g0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
g0043921biological_processmodulation by host of viral transcription
g0045944biological_processpositive regulation of transcription by RNA polymerase II
g1901800biological_processpositive regulation of proteasomal protein catabolic process
g1904813cellular_componentficolin-1-rich granule lumen
h0005524molecular_functionATP binding
h0016887molecular_functionATP hydrolysis activity
i0000502cellular_componentproteasome complex
i0005515molecular_functionprotein binding
i0005576cellular_componentextracellular region
i0005634cellular_componentnucleus
i0005654cellular_componentnucleoplasm
i0005829cellular_componentcytosol
i0005838cellular_componentproteasome regulatory particle
i0008540cellular_componentproteasome regulatory particle, base subcomplex
i0016020cellular_componentmembrane
i0022624cellular_componentproteasome accessory complex
i0030234molecular_functionenzyme regulator activity
i0031625molecular_functionubiquitin protein ligase binding
i0034515cellular_componentproteasome storage granule
i0035578cellular_componentazurophil granule lumen
i0042176biological_processregulation of protein catabolic process
i0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
j0000502cellular_componentproteasome complex
j0005515molecular_functionprotein binding
j0005576cellular_componentextracellular region
j0005634cellular_componentnucleus
j0005654cellular_componentnucleoplasm
j0005829cellular_componentcytosol
j0005838cellular_componentproteasome regulatory particle
j0006511biological_processubiquitin-dependent protein catabolic process
j0008541cellular_componentproteasome regulatory particle, lid subcomplex
j0016020cellular_componentmembrane
j0022624cellular_componentproteasome accessory complex
j0030234molecular_functionenzyme regulator activity
j0032991cellular_componentprotein-containing complex
j0034774cellular_componentsecretory granule lumen
j0042176biological_processregulation of protein catabolic process
j0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
j0070062cellular_componentextracellular exosome
j1904813cellular_componentficolin-1-rich granule lumen
k0000502cellular_componentproteasome complex
k0005515molecular_functionprotein binding
k0005576cellular_componentextracellular region
k0005654cellular_componentnucleoplasm
k0005737cellular_componentcytoplasm
k0005829cellular_componentcytosol
k0005838cellular_componentproteasome regulatory particle
k0008541cellular_componentproteasome regulatory particle, lid subcomplex
k0016020cellular_componentmembrane
k0022624cellular_componentproteasome accessory complex
k0034774cellular_componentsecretory granule lumen
k0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
k0070062cellular_componentextracellular exosome
k1904813cellular_componentficolin-1-rich granule lumen
l0000502cellular_componentproteasome complex
l0005198molecular_functionstructural molecule activity
l0005515molecular_functionprotein binding
l0005576cellular_componentextracellular region
l0005634cellular_componentnucleus
l0005654cellular_componentnucleoplasm
l0005737cellular_componentcytoplasm
l0005829cellular_componentcytosol
l0005838cellular_componentproteasome regulatory particle
l0006511biological_processubiquitin-dependent protein catabolic process
l0008541cellular_componentproteasome regulatory particle, lid subcomplex
l0016020cellular_componentmembrane
l0022624cellular_componentproteasome accessory complex
l0032991cellular_componentprotein-containing complex
l0034774cellular_componentsecretory granule lumen
l0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
l0043248biological_processproteasome assembly
l0048863biological_processstem cell differentiation
l1904813cellular_componentficolin-1-rich granule lumen
m0000502cellular_componentproteasome complex
m0005515molecular_functionprotein binding
m0005576cellular_componentextracellular region
m0005654cellular_componentnucleoplasm
m0005829cellular_componentcytosol
m0005838cellular_componentproteasome regulatory particle
m0022624cellular_componentproteasome accessory complex
m0034774cellular_componentsecretory granule lumen
m0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
m1904813cellular_componentficolin-1-rich granule lumen
n0000502cellular_componentproteasome complex
n0005515molecular_functionprotein binding
n0005576cellular_componentextracellular region
n0005634cellular_componentnucleus
n0005654cellular_componentnucleoplasm
n0005829cellular_componentcytosol
n0005838cellular_componentproteasome regulatory particle
n0008233molecular_functionpeptidase activity
n0008237molecular_functionmetallopeptidase activity
n0016020cellular_componentmembrane
n0034774cellular_componentsecretory granule lumen
n0042803molecular_functionprotein homodimerization activity
n0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
n0070062cellular_componentextracellular exosome
n0140492molecular_functionmetal-dependent deubiquitinase activity
n1904813cellular_componentficolin-1-rich granule lumen
o0000502cellular_componentproteasome complex
o0005198molecular_functionstructural molecule activity
o0005576cellular_componentextracellular region
o0005634cellular_componentnucleus
o0005654cellular_componentnucleoplasm
o0005829cellular_componentcytosol
o0005838cellular_componentproteasome regulatory particle
o0006511biological_processubiquitin-dependent protein catabolic process
o0007127biological_processmeiosis I
o0008541cellular_componentproteasome regulatory particle, lid subcomplex
o0016020cellular_componentmembrane
o0022624cellular_componentproteasome accessory complex
o0034774cellular_componentsecretory granule lumen
o0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
o1904813cellular_componentficolin-1-rich granule lumen
p0000502cellular_componentproteasome complex
p0003723molecular_functionRNA binding
p0005515molecular_functionprotein binding
p0005634cellular_componentnucleus
p0005654cellular_componentnucleoplasm
p0005829cellular_componentcytosol
p0008540cellular_componentproteasome regulatory particle, base subcomplex
p0022624cellular_componentproteasome accessory complex
p0031593molecular_functionpolyubiquitin modification-dependent protein binding
p0042802molecular_functionidentical protein binding
p0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
p0060090molecular_functionmolecular adaptor activity
q0000502cellular_componentproteasome complex
q0000724biological_processdouble-strand break repair via homologous recombination
q0005515molecular_functionprotein binding
q0005576cellular_componentextracellular region
q0005634cellular_componentnucleus
q0005654cellular_componentnucleoplasm
q0005829cellular_componentcytosol
q0006281biological_processDNA repair
q0006303biological_processdouble-strand break repair via nonhomologous end joining
q0006508biological_processproteolysis
q0006511biological_processubiquitin-dependent protein catabolic process
q0006974biological_processDNA damage response
q0008233molecular_functionpeptidase activity
q0008237molecular_functionmetallopeptidase activity
q0008541cellular_componentproteasome regulatory particle, lid subcomplex
q0016787molecular_functionhydrolase activity
q0022624cellular_componentproteasome accessory complex
q0031597cellular_componentcytosolic proteasome complex
q0034774cellular_componentsecretory granule lumen
q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
q0045471biological_processresponse to ethanol
q0046872molecular_functionmetal ion binding
q0061133molecular_functionendopeptidase activator activity
q0061136biological_processregulation of proteasomal protein catabolic process
q0061578molecular_functionK63-linked deubiquitinase activity
q0070536biological_processprotein K63-linked deubiquitination
q0070628molecular_functionproteasome binding
q0140492molecular_functionmetal-dependent deubiquitinase activity
q1904813cellular_componentficolin-1-rich granule lumen
r0000502cellular_componentproteasome complex
r0005515molecular_functionprotein binding
r0005634cellular_componentnucleus
r0005654cellular_componentnucleoplasm
r0005829cellular_componentcytosol
r0005838cellular_componentproteasome regulatory particle
r0006508biological_processproteolysis
r0008541cellular_componentproteasome regulatory particle, lid subcomplex
r0022624cellular_componentproteasome accessory complex
r0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
s0000502cellular_componentproteasome complex
s0000724biological_processdouble-strand break repair via homologous recombination
s0005515molecular_functionprotein binding
s0005634cellular_componentnucleus
s0005654cellular_componentnucleoplasm
s0005829cellular_componentcytosol
s0006406biological_processmRNA export from nucleus
s0008541cellular_componentproteasome regulatory particle, lid subcomplex
s0032039cellular_componentintegrator complex
s0032991cellular_componentprotein-containing complex
s0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
s0043248biological_processproteasome assembly
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue ADP c 501
ChainResidue
cASP176
cILE354
cGLY382
cALA383
cARG386
dARG343
dARG346
cVAL177
cGLY178
cGLY179
cGLY219
cTHR220
cGLY221
cLYS222
cTHR223

site_idAC2
Number of Residues12
Detailsbinding site for residue ADP d 501
ChainResidue
dASP186
dILE187
dGLY229
dGLY231
dLYS232
dTHR233
dLEU234
dILE364
dGLY392
dLYS396
hARG307
hARG310

site_idAC3
Number of Residues12
Detailsbinding site for residue ADP e 501
ChainResidue
eILE167
eGLY168
eMET170
eGLY209
eCYS210
eGLY211
eLYS212
eTHR213
eMET214
eGLY372
eALA373
fARG291

site_idAC4
Number of Residues13
Detailsbinding site for residue ADP g 501
ChainResidue
fGLY136
fLEU138
fGLY177
fTHR178
fGLY179
fLYS180
fTHR181
fLEU182
fILE312
fHIS316
fARG344
gARG344
gARG347

site_idAC5
Number of Residues13
Detailsbinding site for residue ADP g 502
ChainResidue
gASP187
gILE188
gGLY189
gTHR231
gGLY232
gLYS233
gTHR234
gLEU235
gASN333
gILE365
gHIS369
gGLY393
gLYS397

site_idAC6
Number of Residues14
Detailsbinding site for residue ADP h 401
ChainResidue
hMET150
hILE151
hGLY152
hPRO192
hGLY193
hTHR194
hGLY195
hLYS196
hTHR197
hGLU250
hILE328
hHIS332
hGLY356
hLYS360

site_idAC7
Number of Residues14
Detailsbinding site for Ligand residues 6VA t 4 through 6V9 t 1 bound to THR K 1
ChainResidue
KTHR1
KARG19
KALA20
KTHR21
KVAL31
KMET45
KALA46
KGLY47
KALA49
KCYS52
KSER130
KTYR169
LASP125
LVAL127

site_idAC8
Number of Residues13
Detailsbinding site for Ligand 6VA t 4 bound to THR K 1
ChainResidue
KALA46
KGLY47
KALA49
KCYS52
KSER130
KTYR169
t7C93
KTHR1
KARG19
KALA20
KTHR21
KVAL31
KMET45

site_idAC9
Number of Residues13
Detailsbinding site for Ligand residues 6VA u 4 through 6V9 u 1 bound to THR Y 1
ChainResidue
YTHR1
YARG19
YALA20
YTHR21
YVAL31
YMET45
YALA46
YGLY47
YALA49
YCYS52
YSER130
YTYR169
ZASP125

site_idAD1
Number of Residues13
Detailsbinding site for Ligand 6VA u 4 bound to THR Y 1
ChainResidue
YTHR1
YARG19
YALA20
YTHR21
YVAL31
YMET45
YALA46
YGLY47
YALA49
YCYS52
YSER130
YTYR169
u7C93

site_idAD2
Number of Residues4
Detailsbinding site for Ligand VAL m 205 bound to THR m 204
ChainResidue
hARG340
mTHR204
mSER206
mGLU245

site_idAD3
Number of Residues13
Detailsbinding site for Ligand residues MET m 214 through PHE m 208 bound to SER m 206
ChainResidue
hARG340
mVAL182
mSER206
mTHR207
mTHR209
mSER210
mTYR211
mGLU212
mLEU213
mASP215
mTYR216
mTHR218
mPHE219

site_idAD4
Number of Residues9
Detailsbinding site for Di-peptide ASP i 504 and THR i 508
ChainResidue
iASN500
iLEU501
iGLN503
iASP505
iALA506
iVAL507
iGLY509
iGLU510
iALA512

site_idAD5
Number of Residues9
Detailsbinding site for Di-peptide ASP i 504 and THR i 508
ChainResidue
iASN500
iLEU501
iGLN503
iASP505
iALA506
iVAL507
iGLY509
iGLU510
iALA512

site_idAD6
Number of Residues8
Detailsbinding site for Di-peptide LEU i 521 and TYR i 557
ChainResidue
iVAL519
iMET520
iGLY522
iALA553
iLEU554
iVAL555
iMET556
iGLY558

site_idAD7
Number of Residues9
Detailsbinding site for Di-peptide GLY i 522 and GLY i 558
ChainResidue
iMET520
iLEU521
iSER523
iLYS524
iLEU554
iVAL555
iMET556
iTYR557
iARG559

site_idAD8
Number of Residues15
Detailsbinding site for Di-peptide LEU i 548 and SER i 581
ChainResidue
iILE544
iLEU545
iGLY547
iALA549
iVAL550
iILE552
iLEU570
iILE577
iLEU578
iARG579
iARG580
iGLY582
iMET583
iTYR584
iTHR585

site_idAD9
Number of Residues12
Detailsbinding site for Di-peptide LEU l 153 and LEU l 157
ChainResidue
lGLU130
lLEU149
lGLY150
lSER151
lGLN152
lLEU154
lARG155
lGLU156
lLYS158
lLYS159
lMET160
lASP161

site_idAE1
Number of Residues10
Detailsbinding site for Di-peptide ASP l 243 and LYS l 246
ChainResidue
lPHE236
lTYR239
lSER241
lILE242
lSER244
lPRO245
lALA247
lILE248
lTHR249
lSER250

site_idAE2
Number of Residues9
Detailsbinding site for Di-peptide LEU m 134 and GLU m 169
ChainResidue
mALA133
mGLY135
mHIS136
mARG137
mLEU138
mLEU167
mILE168
mGLU170
mGLY171

site_idAE3
Number of Residues9
Detailsbinding site for Di-peptide LEU m 134 and GLU m 169
ChainResidue
mALA133
mGLY135
mHIS136
mARG137
mLEU138
mLEU167
mILE168
mGLU170
mGLY171

site_idAE4
Number of Residues9
Detailsbinding site for Di-peptide LEU m 134 and GLU m 169
ChainResidue
mALA133
mGLY135
mHIS136
mARG137
mLEU138
mLEU167
mILE168
mGLU170
mGLY171

site_idAE5
Number of Residues9
Detailsbinding site for Di-peptide ALA m 198 and LEU m 202
ChainResidue
mGLN196
mALA197
mGLU199
mLEU200
mPHE201
mASP203
mTHR204
mVAL226
mLEU231

site_idAE6
Number of Residues9
Detailsbinding site for Di-peptide GLU m 199 and LEU m 202
ChainResidue
mLYS195
mGLN196
mALA197
mALA198
mLEU200
mPHE201
mASP203
mTHR204
mLEU231

site_idAE7
Number of Residues21
Detailsbinding site for Di-peptide TYR n 250 and ARG j 321
ChainResidue
jILE246
jILE247
jARG248
jLEU249
jHIS251
jASN252
jVAL253
jILE254
jSER319
jTHR320
jGLU322
jPRO323
jLEU325
nVAL246
nLYS247
nALA248
nPHE249
nLEU251
nLYS252
nTHR253
nASN254

site_idAE8
Number of Residues17
Detailsbinding site for Di-peptide LEU n 251 and THR j 320
ChainResidue
jILE247
jARG248
jLEU249
jARG250
jASN252
jVAL253
jLYS255
jSER319
jARG321
nLYS247
nALA248
nPHE249
nTYR250
nLYS252
nTHR253
nASN254
nASP255

Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV
ChainResidueDetails
rALA-6-VAL9

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. AGVvYkdGIVLGADtrategmvvadkncs.KihfispniyccgaGtaAD
ChainResidueDetails
HALA4-ASP51
JILE5-ASP52
bMET4-ASP51
LLEU13-ASP60
BLEU35-ASP82
IMET11-ASP58
KLEU4-ASP51
aLEU12-ASP59

site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. VkVIaATNrvdiLDpALl.R
ChainResidueDetails
gVAL326-ARG344
hILE289-ARG307
dVAL325-ARG343
fVAL273-ARG291
eVAL305-ARG323
cILE315-ARG333

site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvNtFSPeGRlfQVEYAieA
ChainResidueDetails
DTYR8-ALA30
QTYR3-ALA25
ATYR5-ALA27
GPHE9-ALA31
STYR6-ALA28
BTYR5-ALA27
CTYR3-ALA25
ETYR6-ALA28
FTYR7-ALA29

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
rSER28
qHIS115
qASP126
USER17
USER63
USER64

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
rLYS219
nLYS317
LSER134
ZSER34
ZSER40
ZSER134

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17323924
ChainResidueDetails
qSER224
bTHR35
PLYS127
PLYS176
OSER13
OSER15

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
qTHR266
pSER408
SLYS208

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
pLYS122
LSER181
ZSER30
ZSER181

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17323924, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
iSER315
eLYS401

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q3TXS7
ChainResidueDetails
iLYS720
OTYR120

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
iTHR830

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
iSER834

218853

PDB entries from 2024-04-24

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