5LV5

Crystal structure of mouse PRMT6 in complex with inhibitor LH1458

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein arginine N-methyltransferase 6	polymer	403	44597.1	1	UniProt (Q6NZB1) Pfam (PF13649) Pfam (PF22528)	Mus musculus (Mouse)	Histone-arginine N-methyltransferase PRMT6
2	B (A)	2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]-[(3~{S})-3-azanyl-4-oxidanyl-4-oxidanylidene-butyl]azanium	non-polymer		549.6	1	Chemie (78G)
3	C (A)	water	water		18.0	221	Chemie (HOH)

Sequence modifications

A: 1 - 378 (UniProt: Q6NZB1)

PDB	External Database	Details
Met -24	-	initiating methionine
Gly -23	-	expression tag
Ser -22	-	expression tag
Ser -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Thr -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag
Leu 315	Phe 315	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	44597.1
Non-Polymers*	Number of molecules	1
	Total formula weight	549.6
All*	Total formula weight	45146.7

*Water molecules are not included.