Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5LV5

Crystal structure of mouse PRMT6 in complex with inhibitor LH1458

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003682molecular_functionchromatin binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0006281biological_processDNA repair
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0008168molecular_functionmethyltransferase activity
A0008469molecular_functionhistone arginine N-methyltransferase activity
A0010821biological_processregulation of mitochondrion organization
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0018216biological_processpeptidyl-arginine methylation
A0032259biological_processmethylation
A0035241molecular_functionprotein-arginine omega-N monomethyltransferase activity
A0035242molecular_functionprotein-arginine omega-N asymmetric methyltransferase activity
A0036211biological_processprotein modification process
A0042054molecular_functionhistone methyltransferase activity
A0042393molecular_functionhistone binding
A0044020molecular_functionhistone H4R3 methyltransferase activity
A0045892biological_processnegative regulation of DNA-templated transcription
A0070611molecular_functionhistone H3R2 methyltransferase activity
A0070612molecular_functionhistone H2AR3 methyltransferase activity
A0090398biological_processcellular senescence
A1901796biological_processregulation of signal transduction by p53 class mediator
A2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues25
Detailsbinding site for residue 78G A 401
ChainResidue
AMET63
ASER117
AGLY141
APRO142
AVAL143
AGLU144
AGLU158
ATYR162
AGLU167
AMET169
ASER172
AARG69
AHOH507
AHOH517
AHOH535
AHOH585
AHOH595
AHOH614
AGLY93
AALA94
AGLY95
ATHR96
ALEU99
AGLU115
AALA116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AGLU158
AGLU167

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AHIS60
AARG69
AGLY93
AGLU115
AGLU144

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Asymmetric dimethylarginine; by autocatalysis => ECO:0000250
ChainResidueDetails
AARG38

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon