5LV2
Crystal structure of mouse CARM1 in complex with inhibitor LH1246
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Histone-arginine methyltransferase CARM1 | polymer | 361 | 40850.5 | 8 | UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528) | Mus musculus (House Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | HA, I, N, X (G, A, C, E) | 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine | non-polymer | 385.4 | 4 | Chemie (SAO) | |||
| 3 | CA, EA, IA, J, JA... (F, G, A, B, H...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 4 | BA, K, LA, S (F, B, H, D) | 5-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]methyl]-4-azanyl-1-(methoxymethyl)pyrimidin-2-one | non-polymer | 433.4 | 4 | Chemie (LHB) | |||
| 5 | DA, FA, O, T (F, C, D) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 4 | Chemie (PG4) | |||
| 6 | AA, Q (E, C) | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE | non-polymer | 134.2 | 2 | Chemie (M2M) | |||
| 7 | R (C) | 1,2-DIMETHOXYETHANE | non-polymer | 90.1 | 1 | Chemie (DXE) | |||
| 8 | V (D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 9 | GA, W (F, D) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 10 | NA, OA, PA, QA, RA... (A, B, C, D, E...) | water | water | 18.0 | 1166 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 130 - 487 (UniProt: Q9WVG6)
| PDB | External Database | Details |
|---|---|---|
| Gly 127 | - | expression tag |
| His 128 | - | expression tag |
| Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 326803.7 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 5369.7 | |
| All* | Total formula weight | 332173.4 |
