5LV2
Crystal structure of mouse CARM1 in complex with inhibitor LH1246
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Histone-arginine methyltransferase CARM1 | polymer | 361 | 40850.5 | 8 | UniProt (Q9WVG6) Pfam (PF06325) In PDB | Mus musculus (House Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
2 | G, A, C, E | 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine | non-polymer | 385.4 | 4 | Chemie (SAO) | |||
3 | F, G, A, B, H... | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
4 | F, B, H, D | 5-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]methyl]-4-azanyl-1-(methoxymethyl)pyrimidin-2-one | non-polymer | 433.4 | 4 | Chemie (LHB) | |||
5 | F, C, D | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 4 | Chemie (PG4) | |||
6 | E, C | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE | non-polymer | 134.2 | 2 | Chemie (M2M) | |||
7 | C | 1,2-DIMETHOXYETHANE | non-polymer | 90.1 | 1 | Chemie (DXE) | |||
8 | D | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
9 | F, D | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
10 | water | water | 18.0 | 1166 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 130 - 487 (UniProt: Q9WVG6)
PDB | External Database | Details |
---|---|---|
Gly 127 | - | expression tag |
His 128 | - | expression tag |
Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 326803.7 | |
Non-Polymers* | Number of molecules | 31 |
Total formula weight | 5369.7 | |
All* | Total formula weight | 332173.4 |