Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LV2

Crystal structure of mouse CARM1 in complex with inhibitor LH1246

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0018216	biological_process	peptidyl-arginine methylation
D	0016274	molecular_function	protein-arginine N-methyltransferase activity
D	0018216	biological_process	peptidyl-arginine methylation
E	0016274	molecular_function	protein-arginine N-methyltransferase activity
E	0018216	biological_process	peptidyl-arginine methylation
F	0016274	molecular_function	protein-arginine N-methyltransferase activity
F	0018216	biological_process	peptidyl-arginine methylation
G	0016274	molecular_function	protein-arginine N-methyltransferase activity
G	0018216	biological_process	peptidyl-arginine methylation
H	0016274	molecular_function	protein-arginine N-methyltransferase activity
H	0018216	biological_process	peptidyl-arginine methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue SAO A 501

Chain	Residue
A	TYR150
A	GLU215
A	ALA216
A	GLY241
A	LYS242
A	VAL243
A	GLU244
A	GLU258
A	MET269
A	SER272
A	HOH627
A	TYR154
A	HOH629
A	GLN160
A	MET163
A	ARG169
A	GLY193
A	CYS194
A	ILE198
A	LEU199

site_id	AC2
Number of Residues	1
Details	binding site for residue EDO A 502

Chain	Residue
A	TRP404

site_id	AC3
Number of Residues	19
Details	binding site for residue LHB B 501

Chain	Residue
B	TYR150
B	TYR154
B	MET163
B	GLY193
B	GLU215
B	ALA216
B	GLY241
B	LYS242
B	VAL243
B	GLU244
B	GLU258
B	MET260
B	GLY261
B	TYR262
B	GLU267
B	MET269
B	SER272
B	HIS415
B	HOH640

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO B 502

Chain	Residue
B	GLU267
B	LYS471

site_id	AC5
Number of Residues	1
Details	binding site for residue EDO B 503

Chain	Residue
B	TRP404

site_id	AC6
Number of Residues	23
Details	binding site for residue SAO C 501

Chain	Residue
C	TYR150
C	PHE151
C	TYR154
C	GLN160
C	MET163
C	ARG169
C	GLY193
C	CYS194
C	ILE198
C	LEU199
C	GLU215
C	ALA216
C	GLY241
C	LYS242
C	VAL243
C	GLU244
C	GLU258
C	MET269
C	SER272
C	DXE505
C	HOH625
C	HOH627
C	HOH643

site_id	AC7
Number of Residues	3
Details	binding site for residue PG4 C 502

Chain	Residue
B	ASP458
C	LEU178
C	GLN205

site_id	AC8
Number of Residues	1
Details	binding site for residue EDO C 503

Chain	Residue
C	TRP404

site_id	AC9
Number of Residues	4
Details	binding site for residue M2M C 504

Chain	Residue
C	GLN149
C	PHE153
C	GLU267
C	DXE505

site_id	AD1
Number of Residues	9
Details	binding site for residue DXE C 505

Chain	Residue
C	TYR154
C	MET163
C	GLU258
C	MET260
C	GLU267
C	HIS415
C	TRP416
C	SAO501
C	M2M504

site_id	AD2
Number of Residues	21
Details	binding site for residue LHB D 501

Chain	Residue
D	SER272
D	PEG504
D	HOH614
D	HOH621
D	HOH646
D	TYR150
D	PHE151
D	TYR154
D	MET163
D	ARG169
D	GLY193
D	GLU215
D	ALA216
D	LYS242
D	VAL243
D	GLU244
D	GLU258
D	MET260
D	TYR262
D	GLU267
D	MET269

site_id	AD3
Number of Residues	4
Details	binding site for residue PG4 D 502

Chain	Residue
D	SER136
D	GLU244
D	GLU245
D	VAL246

site_id	AD4
Number of Residues	1
Details	binding site for residue EDO D 503

Chain	Residue
D	ASP393

site_id	AD5
Number of Residues	4
Details	binding site for residue PEG D 504

Chain	Residue
D	TYR262
D	GLU267
D	LHB501
D	HOH692

site_id	AD6
Number of Residues	6
Details	binding site for residue NA D 505

Chain	Residue
D	THR407
D	ALA408
D	GLU411
D	PRO412
D	GLN418
D	HOH661

site_id	AD7
Number of Residues	22
Details	binding site for residue SAO E 501

Chain	Residue
E	TYR150
E	TYR154
E	GLN160
E	MET163
E	ARG169
E	GLY193
E	CYS194
E	ILE198
E	LEU199
E	GLU215
E	ALA216
E	GLY241
E	LYS242
E	VAL243
E	GLU244
E	GLU258
E	MET269
E	SER272
E	HOH603
E	HOH620
E	HOH633
E	HOH671

site_id	AD8
Number of Residues	1
Details	binding site for residue EDO E 502

Chain	Residue
E	TRP404

site_id	AD9
Number of Residues	2
Details	binding site for residue EDO E 503

Chain	Residue
E	LEU178
E	HOH610

site_id	AE1
Number of Residues	3
Details	binding site for residue M2M E 504

Chain	Residue
E	GLN149
E	PHE153
E	GLU267

site_id	AE2
Number of Residues	23
Details	binding site for residue LHB F 501

Chain	Residue
F	TYR150
F	PHE151
F	TYR154
F	MET163
F	ARG169
F	GLY193
F	GLU215
F	ALA216
F	GLY241
F	LYS242
F	VAL243
F	GLU244
F	GLU258
F	MET260
F	TYR262
F	GLU267
F	MET269
F	SER272
F	TRP416
F	PG4503
F	HOH623
F	HOH641
F	HOH720

site_id	AE3
Number of Residues	1
Details	binding site for residue EDO F 502

Chain	Residue
F	TYR279

site_id	AE4
Number of Residues	8
Details	binding site for residue PG4 F 503

Chain	Residue
F	TYR150
F	PHE153
F	TYR154
F	TYR262
F	GLU267
F	LYS471
F	LHB501
F	HOH721

site_id	AE5
Number of Residues	2
Details	binding site for residue EDO F 504

Chain	Residue
F	ASP393
F	TRP404

site_id	AE6
Number of Residues	4
Details	binding site for residue PG4 F 505

Chain	Residue
F	SER136
F	GLU244
F	GLU245
F	VAL246

site_id	AE7
Number of Residues	6
Details	binding site for residue NA F 506

Chain	Residue
F	THR407
F	ALA408
F	GLU411
F	PRO412
F	GLN418
F	HOH656

site_id	AE8
Number of Residues	23
Details	binding site for residue SAO G 501

Chain	Residue
G	TYR150
G	TYR154
G	GLN160
G	MET163
G	ARG169
G	GLY193
G	CYS194
G	GLY195
G	ILE198
G	LEU199
G	GLU215
G	ALA216
G	GLY241
G	LYS242
G	VAL243
G	GLU244
G	GLU258
G	MET269
G	SER272
G	HOH607
G	HOH616
G	HOH622
G	HOH682

site_id	AE9
Number of Residues	1
Details	binding site for residue EDO G 502

Chain	Residue
G	TRP404

site_id	AF1
Number of Residues	5
Details	binding site for residue EDO G 503

Chain	Residue
F	ASP458
F	THR460
F	GLY461
G	LEU178
G	GLN205

site_id	AF2
Number of Residues	1
Details	binding site for residue EDO G 504

Chain	Residue
G	PHE153

site_id	AF3
Number of Residues	18
Details	binding site for residue LHB H 501

Chain	Residue
H	TYR150
H	TYR154
H	MET163
H	ARG169
H	GLY193
H	GLU215
H	ALA216
H	LYS242
H	VAL243
H	GLU244
H	GLU258
H	MET260
H	TYR262
H	GLU267
H	MET269
H	SER272
H	HOH601
H	HOH661

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2456
Details	Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	264
Details	Region: {"description":"Required for nuclear translocation","evidences":[{"source":"PubMed","id":"30366907","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17882261","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86X55","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)