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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5LN3

The human 26S Proteasome at 6.8 Ang.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1Z26S proteasome non-ATPase regulatory subunit 2polymer908100313.61UniProt (Q13200)
Pfam (PF17781)
Pfam (PF01851)
Pfam (PF18051)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN1,26S proteasome regulatory subunit S2,26S proteasome subunit p97,Protein 55.11,Tumor necrosis factor type 1 receptor-associated protein 2
21Proteasome subunit beta type-6polymer23925377.71UniProt (P28072)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y
32Proteasome subunit beta type-7polymer27730000.41UniProt (Q99436)
Pfam (PF00227)
Pfam (PF12465)
In PDB		Homo sapiens (Human)Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z
43Proteasome subunit beta type-3polymer20522972.91UniProt (P49720)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain
54Proteasome subunit beta type-2polymer20122864.31UniProt (P49721)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I
65Proteasome subunit beta type-5polymer26328510.21UniProt (P28074)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X
76Proteasome subunit beta type-1polymer24126522.41UniProt (P20618)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain
87Proteasome subunit beta type-4polymer26429231.21UniProt (P28070)
Pfam (PF00227)
In PDB		Homo sapiens (Human)26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3
9AProteasome subunit alpha type-6polymer24627432.51UniProt (P60900)
Pfam (PF00227)
Pfam (PF10584)
In PDB		Homo sapiens (Human)27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain
10BProteasome subunit alpha type-2polymer23425927.51UniProt (P25787)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3
11CProteasome subunit alpha type-4polymer26129525.81UniProt (P25789)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L
12DProteasome subunit alpha type-7polymer24827929.91UniProt (O14818)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Proteasome subunit RC6-1,Proteasome subunit XAPC7
13EProteasome subunit alpha type-5polymer24126436.01UniProt (P28066)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain
14FProteasome subunit alpha type-1polymer26329595.61UniProt (P25786)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain
15GProteasome subunit alpha type-3polymer25528469.31UniProt (P25788)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Homo sapiens (Human)Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8
16H26S protease regulatory subunit 7polymer43348700.81UniProt (P35998)
Pfam (PF21236)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2,Protein MSS1
17I26S protease regulatory subunit 4polymer44049260.51UniProt (P62191)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1
18J26S protease regulatory subunit 8polymer40645694.01UniProt (P62195)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG
19K26S protease regulatory subunit 6Bpolymer41847426.11UniProt (P43686)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7
20L26S protease regulatory subunit 10Bpolymer38944241.01UniProt (P62333)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT4,Proteasome 26S subunit ATPase 6,Proteasome subunit p42
21M26S protease regulatory subunit 6Apolymer43949266.51UniProt (P17980)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB		Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1
22N26S proteasome non-ATPase regulatory subunit 1polymer953105958.21UniProt (Q99460)
Pfam (PF21505)
Pfam (PF01851)
Pfam (PF13646)
Pfam (PF18004)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN2,26S proteasome regulatory subunit S1,26S proteasome subunit p112
23O26S proteasome non-ATPase regulatory subunit 13polymer37642995.41UniProt (Q9UNM6)
Pfam (PF22037)
Pfam (PF01399)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN9,26S proteasome regulatory subunit S11,26S proteasome regulatory subunit p40.5
24P26S proteasome non-ATPase regulatory subunit 12polymer45652979.41UniProt (O00232)
Pfam (PF22241)
Pfam (PF01399)
Pfam (PF18098)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN5,26S proteasome regulatory subunit p55
25Q26S proteasome non-ATPase regulatory subunit 11polymer42247526.71UniProt (O00231)
Pfam (PF18055)
Pfam (PF01399)
Pfam (PF18503)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN6,26S proteasome regulatory subunit S9,26S proteasome regulatory subunit p44.5
26R26S proteasome non-ATPase regulatory subunit 6polymer38945592.31UniProt (Q15008)
Pfam (PF10602)
Pfam (PF01399)
Pfam (PF21154)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN7,26S proteasome regulatory subunit S10,Breast cancer-associated protein SGA-113M,Phosphonoformate immuno-associated protein 4,Proteasome regulatory particle subunit p44S10,p42A
27S26S proteasome non-ATPase regulatory subunit 3polymer53461066.51UniProt (O43242)
Pfam (PF01399)
Pfam (PF08375)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,Proteasome subunit p58
28T26S proteasome non-ATPase regulatory subunit 8polymer35039667.91UniProt (P48556)
Pfam (PF10075)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,p31
29U26S proteasome non-ATPase regulatory subunit 7polymer32437086.41UniProt (P51665)
Pfam (PF01398)
Pfam (PF13012)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40
30V26S proteasome non-ATPase regulatory subunit 14polymer31034620.01UniProt (O00487)
Pfam (PF01398)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1
31W26S proteasome non-ATPase regulatory subunit 4polymer37740781.61UniProt (P55036)
Pfam (PF13519)
Pfam (PF02809)
In PDB		Homo sapiens (Human)26S proteasome regulatory subunit RPN10,26S proteasome regulatory subunit S5A,Antisecretory factor 1,ASF,Multiubiquitin chain-binding protein
32Y26S proteasome complex subunit DSS1polymer708284.61UniProt (P60896)
Pfam (PF05160)
In PDB		Homo sapiens (Human)Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains32
Total formula weight1282257.2
All*Total formula weight1282257.2
*Water molecules are not included.

222036

PDB entries from 2024-07-03

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