5LN3

The human 26S Proteasome at 6.8 Ang.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0006281	biological_process	DNA repair
1	0006508	biological_process	proteolysis
1	0006915	biological_process	apoptotic process
1	0006974	biological_process	DNA damage response
1	0006979	biological_process	response to oxidative stress
1	0007283	biological_process	spermatogenesis
1	0008021	cellular_component	synaptic vesicle
1	0008233	molecular_function	peptidase activity
1	0010498	biological_process	proteasomal protein catabolic process
1	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
1	0016787	molecular_function	hydrolase activity
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0030317	biological_process	flagellated sperm motility
1	0034515	cellular_component	proteasome storage granule
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0045296	molecular_function	cadherin binding
1	0051321	biological_process	meiotic cell cycle
1	0051603	biological_process	proteolysis involved in protein catabolic process
1	0061136	biological_process	regulation of proteasomal protein catabolic process
1	0070062	cellular_component	extracellular exosome
1	0071357	biological_process	cellular response to type I interferon
1	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
2	0000502	cellular_component	proteasome complex
2	0004175	molecular_function	endopeptidase activity
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005515	molecular_function	protein binding
2	0005576	cellular_component	extracellular region
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005839	cellular_component	proteasome core complex
2	0006281	biological_process	DNA repair
2	0006508	biological_process	proteolysis
2	0006915	biological_process	apoptotic process
2	0006974	biological_process	DNA damage response
2	0006979	biological_process	response to oxidative stress
2	0007283	biological_process	spermatogenesis
2	0008021	cellular_component	synaptic vesicle
2	0008233	molecular_function	peptidase activity
2	0010498	biological_process	proteasomal protein catabolic process
2	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
2	0016604	cellular_component	nuclear body
2	0016787	molecular_function	hydrolase activity
2	0019774	cellular_component	proteasome core complex, beta-subunit complex
2	0030317	biological_process	flagellated sperm motility
2	0034515	cellular_component	proteasome storage granule
2	0034774	cellular_component	secretory granule lumen
2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0051321	biological_process	meiotic cell cycle
2	0051603	biological_process	proteolysis involved in protein catabolic process
2	0061136	biological_process	regulation of proteasomal protein catabolic process
2	0071357	biological_process	cellular response to type I interferon
2	1904813	cellular_component	ficolin-1-rich granule lumen
2	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
3	0000502	cellular_component	proteasome complex
3	0002376	biological_process	immune system process
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005839	cellular_component	proteasome core complex
3	0006281	biological_process	DNA repair
3	0006915	biological_process	apoptotic process
3	0006974	biological_process	DNA damage response
3	0006979	biological_process	response to oxidative stress
3	0007283	biological_process	spermatogenesis
3	0008021	cellular_component	synaptic vesicle
3	0010498	biological_process	proteasomal protein catabolic process
3	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0030317	biological_process	flagellated sperm motility
3	0032729	biological_process	positive regulation of type II interferon production
3	0032743	biological_process	positive regulation of interleukin-2 production
3	0032760	biological_process	positive regulation of tumor necrosis factor production
3	0034341	biological_process	response to type II interferon
3	0034515	cellular_component	proteasome storage granule
3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
3	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
3	0045061	biological_process	thymic T cell selection
3	0045063	biological_process	T-helper 1 cell differentiation
3	0045590	biological_process	negative regulation of regulatory T cell differentiation
3	0051321	biological_process	meiotic cell cycle
3	0051603	biological_process	proteolysis involved in protein catabolic process
3	0061136	biological_process	regulation of proteasomal protein catabolic process
3	0070062	cellular_component	extracellular exosome
3	0071357	biological_process	cellular response to type I interferon
3	0072539	biological_process	T-helper 17 cell differentiation
3	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
3	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
4	0000502	cellular_component	proteasome complex
4	0002376	biological_process	immune system process
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005737	cellular_component	cytoplasm
4	0005829	cellular_component	cytosol
4	0005839	cellular_component	proteasome core complex
4	0006281	biological_process	DNA repair
4	0006915	biological_process	apoptotic process
4	0006974	biological_process	DNA damage response
4	0006979	biological_process	response to oxidative stress
4	0007283	biological_process	spermatogenesis
4	0008021	cellular_component	synaptic vesicle
4	0010498	biological_process	proteasomal protein catabolic process
4	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
4	0016020	cellular_component	membrane
4	0019774	cellular_component	proteasome core complex, beta-subunit complex
4	0030317	biological_process	flagellated sperm motility
4	0032729	biological_process	positive regulation of type II interferon production
4	0032743	biological_process	positive regulation of interleukin-2 production
4	0032760	biological_process	positive regulation of tumor necrosis factor production
4	0034341	biological_process	response to type II interferon
4	0034515	cellular_component	proteasome storage granule
4	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
4	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
4	0045061	biological_process	thymic T cell selection
4	0045063	biological_process	T-helper 1 cell differentiation
4	0045590	biological_process	negative regulation of regulatory T cell differentiation
4	0051321	biological_process	meiotic cell cycle
4	0051603	biological_process	proteolysis involved in protein catabolic process
4	0061136	biological_process	regulation of proteasomal protein catabolic process
4	0070062	cellular_component	extracellular exosome
4	0071357	biological_process	cellular response to type I interferon
4	0072539	biological_process	T-helper 17 cell differentiation
4	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
4	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
5	0000502	cellular_component	proteasome complex
5	0004175	molecular_function	endopeptidase activity
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005737	cellular_component	cytoplasm
5	0005829	cellular_component	cytosol
5	0005839	cellular_component	proteasome core complex
5	0006281	biological_process	DNA repair
5	0006508	biological_process	proteolysis
5	0006915	biological_process	apoptotic process
5	0006974	biological_process	DNA damage response
5	0006979	biological_process	response to oxidative stress
5	0007283	biological_process	spermatogenesis
5	0008021	cellular_component	synaptic vesicle
5	0008233	molecular_function	peptidase activity
5	0010498	biological_process	proteasomal protein catabolic process
5	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
5	0016787	molecular_function	hydrolase activity
5	0019774	cellular_component	proteasome core complex, beta-subunit complex
5	0030317	biological_process	flagellated sperm motility
5	0034515	cellular_component	proteasome storage granule
5	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
5	0043248	biological_process	proteasome assembly
5	0051321	biological_process	meiotic cell cycle
5	0051603	biological_process	proteolysis involved in protein catabolic process
5	0061136	biological_process	regulation of proteasomal protein catabolic process
5	0070062	cellular_component	extracellular exosome
5	0071357	biological_process	cellular response to type I interferon
5	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
6	0000502	cellular_component	proteasome complex
6	0002376	biological_process	immune system process
6	0005515	molecular_function	protein binding
6	0005576	cellular_component	extracellular region
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005737	cellular_component	cytoplasm
6	0005829	cellular_component	cytosol
6	0005839	cellular_component	proteasome core complex
6	0006281	biological_process	DNA repair
6	0006915	biological_process	apoptotic process
6	0006974	biological_process	DNA damage response
6	0006979	biological_process	response to oxidative stress
6	0007283	biological_process	spermatogenesis
6	0008021	cellular_component	synaptic vesicle
6	0010498	biological_process	proteasomal protein catabolic process
6	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
6	0019774	cellular_component	proteasome core complex, beta-subunit complex
6	0030317	biological_process	flagellated sperm motility
6	0032729	biological_process	positive regulation of type II interferon production
6	0032743	biological_process	positive regulation of interleukin-2 production
6	0032760	biological_process	positive regulation of tumor necrosis factor production
6	0034341	biological_process	response to type II interferon
6	0034515	cellular_component	proteasome storage granule
6	0034774	cellular_component	secretory granule lumen
6	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
6	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
6	0045061	biological_process	thymic T cell selection
6	0045063	biological_process	T-helper 1 cell differentiation
6	0045590	biological_process	negative regulation of regulatory T cell differentiation
6	0051321	biological_process	meiotic cell cycle
6	0051603	biological_process	proteolysis involved in protein catabolic process
6	0061136	biological_process	regulation of proteasomal protein catabolic process
6	0070062	cellular_component	extracellular exosome
6	0071357	biological_process	cellular response to type I interferon
6	0072539	biological_process	T-helper 17 cell differentiation
6	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
6	1904813	cellular_component	ficolin-1-rich granule lumen
6	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
7	0000502	cellular_component	proteasome complex
7	0001530	molecular_function	lipopolysaccharide binding
7	0002376	biological_process	immune system process
7	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005737	cellular_component	cytoplasm
7	0005829	cellular_component	cytosol
7	0005839	cellular_component	proteasome core complex
7	0006281	biological_process	DNA repair
7	0006915	biological_process	apoptotic process
7	0006974	biological_process	DNA damage response
7	0006979	biological_process	response to oxidative stress
7	0007283	biological_process	spermatogenesis
7	0008021	cellular_component	synaptic vesicle
7	0010498	biological_process	proteasomal protein catabolic process
7	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
7	0019774	cellular_component	proteasome core complex, beta-subunit complex
7	0030317	biological_process	flagellated sperm motility
7	0032729	biological_process	positive regulation of type II interferon production
7	0032743	biological_process	positive regulation of interleukin-2 production
7	0032760	biological_process	positive regulation of tumor necrosis factor production
7	0034341	biological_process	response to type II interferon
7	0034515	cellular_component	proteasome storage granule
7	0036064	cellular_component	ciliary basal body
7	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
7	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
7	0045061	biological_process	thymic T cell selection
7	0045063	biological_process	T-helper 1 cell differentiation
7	0045590	biological_process	negative regulation of regulatory T cell differentiation
7	0051321	biological_process	meiotic cell cycle
7	0051603	biological_process	proteolysis involved in protein catabolic process
7	0061136	biological_process	regulation of proteasomal protein catabolic process
7	0070062	cellular_component	extracellular exosome
7	0071357	biological_process	cellular response to type I interferon
7	0072539	biological_process	T-helper 17 cell differentiation
7	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
7	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0004175	molecular_function	endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0005840	cellular_component	ribosome
A	0006281	biological_process	DNA repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0008021	cellular_component	synaptic vesicle
A	0010498	biological_process	proteasomal protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0016363	cellular_component	nuclear matrix
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030016	cellular_component	myofibril
A	0030017	cellular_component	sarcomere
A	0030317	biological_process	flagellated sperm motility
A	0032729	biological_process	positive regulation of type II interferon production
A	0032743	biological_process	positive regulation of interleukin-2 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0034341	biological_process	response to type II interferon
A	0034515	cellular_component	proteasome storage granule
A	0035639	molecular_function	purine ribonucleoside triphosphate binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
A	0045061	biological_process	thymic T cell selection
A	0045063	biological_process	T-helper 1 cell differentiation
A	0045590	biological_process	negative regulation of regulatory T cell differentiation
A	0050727	biological_process	regulation of inflammatory response
A	0051059	molecular_function	NF-kappaB binding
A	0051321	biological_process	meiotic cell cycle
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	0071357	biological_process	cellular response to type I interferon
A	0072539	biological_process	T-helper 17 cell differentiation
A	0097229	cellular_component	sperm end piece
A	0097542	cellular_component	ciliary tip
A	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006281	biological_process	DNA repair
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007283	biological_process	spermatogenesis
B	0008021	cellular_component	synaptic vesicle
B	0009615	biological_process	response to virus
B	0010498	biological_process	proteasomal protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030317	biological_process	flagellated sperm motility
B	0032729	biological_process	positive regulation of type II interferon production
B	0032743	biological_process	positive regulation of interleukin-2 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0034341	biological_process	response to type II interferon
B	0034515	cellular_component	proteasome storage granule
B	0034774	cellular_component	secretory granule lumen
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
B	0045061	biological_process	thymic T cell selection
B	0045063	biological_process	T-helper 1 cell differentiation
B	0045590	biological_process	negative regulation of regulatory T cell differentiation
B	0051321	biological_process	meiotic cell cycle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	0070062	cellular_component	extracellular exosome
B	0071357	biological_process	cellular response to type I interferon
B	0072539	biological_process	T-helper 17 cell differentiation
B	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
C	0000502	cellular_component	proteasome complex
C	0000932	cellular_component	P-body
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0006979	biological_process	response to oxidative stress
C	0007283	biological_process	spermatogenesis
C	0008021	cellular_component	synaptic vesicle
C	0010498	biological_process	proteasomal protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030317	biological_process	flagellated sperm motility
C	0032729	biological_process	positive regulation of type II interferon production
C	0032743	biological_process	positive regulation of interleukin-2 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0034341	biological_process	response to type II interferon
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
C	0045061	biological_process	thymic T cell selection
C	0045063	biological_process	T-helper 1 cell differentiation
C	0045590	biological_process	negative regulation of regulatory T cell differentiation
C	0051321	biological_process	meiotic cell cycle
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	0071357	biological_process	cellular response to type I interferon
C	0072539	biological_process	T-helper 17 cell differentiation
C	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
C	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	0000502	cellular_component	proteasome complex
D	0002376	biological_process	immune system process
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006281	biological_process	DNA repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0008021	cellular_component	synaptic vesicle
D	0010498	biological_process	proteasomal protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030317	biological_process	flagellated sperm motility
D	0032729	biological_process	positive regulation of type II interferon production
D	0032743	biological_process	positive regulation of interleukin-2 production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0034341	biological_process	response to type II interferon
D	0034515	cellular_component	proteasome storage granule
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
D	0045061	biological_process	thymic T cell selection
D	0045063	biological_process	T-helper 1 cell differentiation
D	0045590	biological_process	negative regulation of regulatory T cell differentiation
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	0071357	biological_process	cellular response to type I interferon
D	0072539	biological_process	T-helper 17 cell differentiation
D	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
D	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	0000502	cellular_component	proteasome complex
E	0002376	biological_process	immune system process
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006281	biological_process	DNA repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0006979	biological_process	response to oxidative stress
E	0007283	biological_process	spermatogenesis
E	0008021	cellular_component	synaptic vesicle
E	0010498	biological_process	proteasomal protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030317	biological_process	flagellated sperm motility
E	0032729	biological_process	positive regulation of type II interferon production
E	0032743	biological_process	positive regulation of interleukin-2 production
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0034341	biological_process	response to type II interferon
E	0034515	cellular_component	proteasome storage granule
E	0034774	cellular_component	secretory granule lumen
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
E	0045061	biological_process	thymic T cell selection
E	0045063	biological_process	T-helper 1 cell differentiation
E	0045590	biological_process	negative regulation of regulatory T cell differentiation
E	0051321	biological_process	meiotic cell cycle
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070062	cellular_component	extracellular exosome
E	0071357	biological_process	cellular response to type I interferon
E	0072539	biological_process	T-helper 17 cell differentiation
E	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
F	0000502	cellular_component	proteasome complex
F	0001530	molecular_function	lipopolysaccharide binding
F	0002376	biological_process	immune system process
F	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006281	biological_process	DNA repair
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0006979	biological_process	response to oxidative stress
F	0007283	biological_process	spermatogenesis
F	0008021	cellular_component	synaptic vesicle
F	0010498	biological_process	proteasomal protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0016604	cellular_component	nuclear body
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030317	biological_process	flagellated sperm motility
F	0032729	biological_process	positive regulation of type II interferon production
F	0032743	biological_process	positive regulation of interleukin-2 production
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0034341	biological_process	response to type II interferon
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
F	0045061	biological_process	thymic T cell selection
F	0045063	biological_process	T-helper 1 cell differentiation
F	0045590	biological_process	negative regulation of regulatory T cell differentiation
F	0051321	biological_process	meiotic cell cycle
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0061136	biological_process	regulation of proteasomal protein catabolic process
F	0070062	cellular_component	extracellular exosome
F	0071357	biological_process	cellular response to type I interferon
F	0072539	biological_process	T-helper 17 cell differentiation
F	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	0000502	cellular_component	proteasome complex
G	0002376	biological_process	immune system process
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006281	biological_process	DNA repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0008021	cellular_component	synaptic vesicle
G	0010498	biological_process	proteasomal protein catabolic process
G	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030317	biological_process	flagellated sperm motility
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032729	biological_process	positive regulation of type II interferon production
G	0032743	biological_process	positive regulation of interleukin-2 production
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0034341	biological_process	response to type II interferon
G	0034515	cellular_component	proteasome storage granule
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
G	0045061	biological_process	thymic T cell selection
G	0045063	biological_process	T-helper 1 cell differentiation
G	0045590	biological_process	negative regulation of regulatory T cell differentiation
G	0051321	biological_process	meiotic cell cycle
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0070062	cellular_component	extracellular exosome
G	0071357	biological_process	cellular response to type I interferon
G	0072539	biological_process	T-helper 17 cell differentiation
G	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
G	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
H	0000166	molecular_function	nucleotide binding
H	0000502	cellular_component	proteasome complex
H	0000932	cellular_component	P-body
H	0001649	biological_process	osteoblast differentiation
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006979	biological_process	response to oxidative stress
H	0008021	cellular_component	synaptic vesicle
H	0008540	cellular_component	proteasome regulatory particle, base subcomplex
H	0010498	biological_process	proteasomal protein catabolic process
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0022624	cellular_component	proteasome accessory complex
H	0034774	cellular_component	secretory granule lumen
H	0036402	molecular_function	proteasome-activating activity
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0061136	biological_process	regulation of proteasomal protein catabolic process
H	0071357	biological_process	cellular response to type I interferon
H	1901800	biological_process	positive regulation of proteasomal protein catabolic process
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0000166	molecular_function	nucleotide binding
I	0000502	cellular_component	proteasome complex
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005838	cellular_component	proteasome regulatory particle
I	0006979	biological_process	response to oxidative stress
I	0008021	cellular_component	synaptic vesicle
I	0008540	cellular_component	proteasome regulatory particle, base subcomplex
I	0010498	biological_process	proteasomal protein catabolic process
I	0016020	cellular_component	membrane
I	0016887	molecular_function	ATP hydrolysis activity
I	0022624	cellular_component	proteasome accessory complex
I	0036402	molecular_function	proteasome-activating activity
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0061136	biological_process	regulation of proteasomal protein catabolic process
I	0071357	biological_process	cellular response to type I interferon
J	0000166	molecular_function	nucleotide binding
J	0000502	cellular_component	proteasome complex
J	0005102	molecular_function	signaling receptor binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005838	cellular_component	proteasome regulatory particle
J	0005886	cellular_component	plasma membrane
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006979	biological_process	response to oxidative stress
J	0008021	cellular_component	synaptic vesicle
J	0008134	molecular_function	transcription factor binding
J	0008540	cellular_component	proteasome regulatory particle, base subcomplex
J	0010498	biological_process	proteasomal protein catabolic process
J	0016020	cellular_component	membrane
J	0016234	cellular_component	inclusion body
J	0016887	molecular_function	ATP hydrolysis activity
J	0017025	molecular_function	TBP-class protein binding
J	0022624	cellular_component	proteasome accessory complex
J	0031410	cellular_component	cytoplasmic vesicle
J	0031531	molecular_function	thyrotropin-releasing hormone receptor binding
J	0031595	cellular_component	nuclear proteasome complex
J	0031597	cellular_component	cytosolic proteasome complex
J	0036402	molecular_function	proteasome-activating activity
J	0043069	biological_process	negative regulation of programmed cell death
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0061136	biological_process	regulation of proteasomal protein catabolic process
J	0070062	cellular_component	extracellular exosome
J	0071357	biological_process	cellular response to type I interferon
J	0072562	cellular_component	blood microparticle
J	0090261	biological_process	positive regulation of inclusion body assembly
J	0140296	molecular_function	general transcription initiation factor binding
J	0140297	molecular_function	DNA-binding transcription factor binding
J	1901800	biological_process	positive regulation of proteasomal protein catabolic process
K	0000166	molecular_function	nucleotide binding
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006508	biological_process	proteolysis
K	0006979	biological_process	response to oxidative stress
K	0008021	cellular_component	synaptic vesicle
K	0008540	cellular_component	proteasome regulatory particle, base subcomplex
K	0010498	biological_process	proteasomal protein catabolic process
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0022624	cellular_component	proteasome accessory complex
K	0036402	molecular_function	proteasome-activating activity
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0061136	biological_process	regulation of proteasomal protein catabolic process
K	0071357	biological_process	cellular response to type I interferon
L	0000166	molecular_function	nucleotide binding
L	0000502	cellular_component	proteasome complex
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006979	biological_process	response to oxidative stress
L	0008021	cellular_component	synaptic vesicle
L	0008540	cellular_component	proteasome regulatory particle, base subcomplex
L	0010498	biological_process	proteasomal protein catabolic process
L	0016020	cellular_component	membrane
L	0016234	cellular_component	inclusion body
L	0016887	molecular_function	ATP hydrolysis activity
L	0022624	cellular_component	proteasome accessory complex
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0031597	cellular_component	cytosolic proteasome complex
L	0036402	molecular_function	proteasome-activating activity
L	0036503	biological_process	ERAD pathway
L	0042802	molecular_function	identical protein binding
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
L	0061136	biological_process	regulation of proteasomal protein catabolic process
L	0070062	cellular_component	extracellular exosome
L	0071357	biological_process	cellular response to type I interferon
L	0090261	biological_process	positive regulation of inclusion body assembly
L	1901800	biological_process	positive regulation of proteasomal protein catabolic process
M	0000166	molecular_function	nucleotide binding
M	0000502	cellular_component	proteasome complex
M	0000932	cellular_component	P-body
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006979	biological_process	response to oxidative stress
M	0008021	cellular_component	synaptic vesicle
M	0008540	cellular_component	proteasome regulatory particle, base subcomplex
M	0010498	biological_process	proteasomal protein catabolic process
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0022624	cellular_component	proteasome accessory complex
M	0034774	cellular_component	secretory granule lumen
M	0036402	molecular_function	proteasome-activating activity
M	0042802	molecular_function	identical protein binding
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0043921	biological_process	host-mediated perturbation of viral transcription
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0061136	biological_process	regulation of proteasomal protein catabolic process
M	0071357	biological_process	cellular response to type I interferon
M	1901800	biological_process	positive regulation of proteasomal protein catabolic process
M	1904813	cellular_component	ficolin-1-rich granule lumen
N	0000502	cellular_component	proteasome complex
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005829	cellular_component	cytosol
N	0005838	cellular_component	proteasome regulatory particle
N	0006979	biological_process	response to oxidative stress
N	0008021	cellular_component	synaptic vesicle
N	0008540	cellular_component	proteasome regulatory particle, base subcomplex
N	0010498	biological_process	proteasomal protein catabolic process
N	0016020	cellular_component	membrane
N	0022624	cellular_component	proteasome accessory complex
N	0030234	molecular_function	enzyme regulator activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0034515	cellular_component	proteasome storage granule
N	0035578	cellular_component	azurophil granule lumen
N	0042176	biological_process	regulation of protein catabolic process
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0061136	biological_process	regulation of proteasomal protein catabolic process
N	0071357	biological_process	cellular response to type I interferon
O	0000502	cellular_component	proteasome complex
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005829	cellular_component	cytosol
O	0005838	cellular_component	proteasome regulatory particle
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0006979	biological_process	response to oxidative stress
O	0008021	cellular_component	synaptic vesicle
O	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
O	0010498	biological_process	proteasomal protein catabolic process
O	0016020	cellular_component	membrane
O	0022624	cellular_component	proteasome accessory complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0061136	biological_process	regulation of proteasomal protein catabolic process
O	0071357	biological_process	cellular response to type I interferon
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000502	cellular_component	proteasome complex
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005838	cellular_component	proteasome regulatory particle
P	0006979	biological_process	response to oxidative stress
P	0008021	cellular_component	synaptic vesicle
P	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
P	0010498	biological_process	proteasomal protein catabolic process
P	0016020	cellular_component	membrane
P	0022624	cellular_component	proteasome accessory complex
P	0034774	cellular_component	secretory granule lumen
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	0071357	biological_process	cellular response to type I interferon
P	1904813	cellular_component	ficolin-1-rich granule lumen
Q	0000502	cellular_component	proteasome complex
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005829	cellular_component	cytosol
Q	0005838	cellular_component	proteasome regulatory particle
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0006979	biological_process	response to oxidative stress
Q	0008021	cellular_component	synaptic vesicle
Q	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0016020	cellular_component	membrane
Q	0022624	cellular_component	proteasome accessory complex
Q	0032991	cellular_component	protein-containing complex
Q	0034774	cellular_component	secretory granule lumen
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043248	biological_process	proteasome assembly
Q	0048863	biological_process	stem cell differentiation
Q	0061136	biological_process	regulation of proteasomal protein catabolic process
Q	0071357	biological_process	cellular response to type I interferon
Q	1904813	cellular_component	ficolin-1-rich granule lumen
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005654	cellular_component	nucleoplasm
R	0005829	cellular_component	cytosol
R	0005838	cellular_component	proteasome regulatory particle
R	0006979	biological_process	response to oxidative stress
R	0008021	cellular_component	synaptic vesicle
R	0010498	biological_process	proteasomal protein catabolic process
R	0022624	cellular_component	proteasome accessory complex
R	0032991	cellular_component	protein-containing complex
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0061136	biological_process	regulation of proteasomal protein catabolic process
R	0071357	biological_process	cellular response to type I interferon
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005829	cellular_component	cytosol
S	0005838	cellular_component	proteasome regulatory particle
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0006979	biological_process	response to oxidative stress
S	0008021	cellular_component	synaptic vesicle
S	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
S	0010498	biological_process	proteasomal protein catabolic process
S	0016020	cellular_component	membrane
S	0022624	cellular_component	proteasome accessory complex
S	0030234	molecular_function	enzyme regulator activity
S	0034774	cellular_component	secretory granule lumen
S	0042176	biological_process	regulation of protein catabolic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0061136	biological_process	regulation of proteasomal protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	0071357	biological_process	cellular response to type I interferon
S	1904813	cellular_component	ficolin-1-rich granule lumen
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005829	cellular_component	cytosol
T	0005838	cellular_component	proteasome regulatory particle
T	0006508	biological_process	proteolysis
T	0006979	biological_process	response to oxidative stress
T	0008021	cellular_component	synaptic vesicle
T	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
T	0010498	biological_process	proteasomal protein catabolic process
T	0022624	cellular_component	proteasome accessory complex
T	0032991	cellular_component	protein-containing complex
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0061136	biological_process	regulation of proteasomal protein catabolic process
T	0071357	biological_process	cellular response to type I interferon
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0005838	cellular_component	proteasome regulatory particle
U	0006979	biological_process	response to oxidative stress
U	0008021	cellular_component	synaptic vesicle
U	0008233	molecular_function	peptidase activity
U	0008237	molecular_function	metallopeptidase activity
U	0010498	biological_process	proteasomal protein catabolic process
U	0016020	cellular_component	membrane
U	0034774	cellular_component	secretory granule lumen
U	0042803	molecular_function	protein homodimerization activity
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0061136	biological_process	regulation of proteasomal protein catabolic process
U	0070062	cellular_component	extracellular exosome
U	0071357	biological_process	cellular response to type I interferon
U	0140492	molecular_function	metal-dependent deubiquitinase activity
U	1904813	cellular_component	ficolin-1-rich granule lumen
V	0000502	cellular_component	proteasome complex
V	0000724	biological_process	double-strand break repair via homologous recombination
V	0004843	molecular_function	cysteine-type deubiquitinase activity
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005829	cellular_component	cytosol
V	0006281	biological_process	DNA repair
V	0006303	biological_process	double-strand break repair via nonhomologous end joining
V	0006508	biological_process	proteolysis
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
V	0006914	biological_process	autophagy
V	0006974	biological_process	DNA damage response
V	0006979	biological_process	response to oxidative stress
V	0008021	cellular_component	synaptic vesicle
V	0008233	molecular_function	peptidase activity
V	0008234	molecular_function	cysteine-type peptidase activity
V	0008237	molecular_function	metallopeptidase activity
V	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
V	0010498	biological_process	proteasomal protein catabolic process
V	0016192	biological_process	vesicle-mediated transport
V	0016241	biological_process	regulation of macroautophagy
V	0016579	biological_process	protein deubiquitination
V	0016787	molecular_function	hydrolase activity
V	0022624	cellular_component	proteasome accessory complex
V	0031597	cellular_component	cytosolic proteasome complex
V	0034774	cellular_component	secretory granule lumen
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0045471	biological_process	response to ethanol
V	0046872	molecular_function	metal ion binding
V	0061133	molecular_function	endopeptidase activator activity
V	0061136	biological_process	regulation of proteasomal protein catabolic process
V	0061578	molecular_function	K63-linked deubiquitinase activity
V	0070536	biological_process	protein K63-linked deubiquitination
V	0070628	molecular_function	proteasome binding
V	0071357	biological_process	cellular response to type I interferon
V	0140492	molecular_function	metal-dependent deubiquitinase activity
V	1904813	cellular_component	ficolin-1-rich granule lumen
W	0000502	cellular_component	proteasome complex
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005829	cellular_component	cytosol
W	0006979	biological_process	response to oxidative stress
W	0008021	cellular_component	synaptic vesicle
W	0008540	cellular_component	proteasome regulatory particle, base subcomplex
W	0010498	biological_process	proteasomal protein catabolic process
W	0022624	cellular_component	proteasome accessory complex
W	0031593	molecular_function	polyubiquitin modification-dependent protein binding
W	0042802	molecular_function	identical protein binding
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0060090	molecular_function	molecular adaptor activity
W	0061136	biological_process	regulation of proteasomal protein catabolic process
W	0071357	biological_process	cellular response to type I interferon
Y	0000502	cellular_component	proteasome complex
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005829	cellular_component	cytosol
Y	0006406	biological_process	mRNA export from nucleus
Y	0006979	biological_process	response to oxidative stress
Y	0008021	cellular_component	synaptic vesicle
Y	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0032039	cellular_component	integrator complex
Y	0032991	cellular_component	protein-containing complex
Y	0043130	molecular_function	ubiquitin binding
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043248	biological_process	proteasome assembly
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0061136	biological_process	regulation of proteasomal protein catabolic process
Y	0071357	biological_process	cellular response to type I interferon
Z	0000502	cellular_component	proteasome complex
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005829	cellular_component	cytosol
Z	0005838	cellular_component	proteasome regulatory particle
Z	0006979	biological_process	response to oxidative stress
Z	0008021	cellular_component	synaptic vesicle
Z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0016020	cellular_component	membrane
Z	0022624	cellular_component	proteasome accessory complex
Z	0030234	molecular_function	enzyme regulator activity
Z	0034515	cellular_component	proteasome storage granule
Z	0034774	cellular_component	secretory granule lumen
Z	0042176	biological_process	regulation of protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0061136	biological_process	regulation of proteasomal protein catabolic process
Z	0070062	cellular_component	extracellular exosome
Z	0071357	biological_process	cellular response to type I interferon
Z	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV

Chain	Residue	Details
T	ALA72-VAL87

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlvQIEYAlaA

Chain	Residue	Details
B	TYR6-ALA28
G	TYR8-ALA30
F	TYR6-ALA28
E	TYR8-ALA30
D	TYR3-ALA25
A	PHE9-ALA31
C	TYR5-ALA27

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVIaATNrvdiLDpALl.R

Chain	Residue	Details
M	VAL326-ARG344
K	VAL305-ARG323
H	ILE315-ARG333
I	VAL325-ARG343
J	ILE289-ARG307
L	VAL273-ARG291

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAMkGknCVAIAADrrfgiqaqmvttdfq.KifpmgdrlyiglaGlaTD

Chain	Residue	Details
3	MET12-ASP59
2	ALA47-ASP94
7	LEU57-ASP104
1	MET38-ASP85
5	LEU63-ASP110
6	LEU41-ASP88
4	ILE5-ASP52
C	LEU35-ASP82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	66
Details	Repeat: {"description":"PC 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	69
Details	Repeat: {"description":"PC 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	68
Details	Repeat: {"description":"PC 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	68
Details	Repeat: {"description":"PC 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	62
Details	Repeat: {"description":"PC 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	66
Details	Repeat: {"description":"PC 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	47
Details	Repeat: {"description":"PC 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	25
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	41
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P18420","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	17
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15144186","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"17370265","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	34
Details	Repeat: {"description":"PC 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	40
Details	Repeat: {"description":"PC 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	32
Details	Repeat: {"description":"PC 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3TXS7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	1029
Details	Domain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2004","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Potts A.","Brablan J.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	135
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	13
Details	Motif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17693683","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---