5LHQ
The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Urokinase-type plasminogen activator | polymer | 247 | 27554.2 | 1 | UniProt (P06869) Pfam (PF00089) In PDB | Mus musculus (House Mouse) | uPA |
| 2 | B | Camelid-Derived Antibody Fragment Nb7 | polymer | 152 | 16303.9 | 1 | Vicugna pacos (Alpaca) | ||
| 3 | A | L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide | non-polymer | 395.9 | 1 | BIRD (PRD_000288) Chemie (0GJ) | |||
| 4 | A, B | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A: 16 - 243 (UniProt: P06869)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 301 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43858.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1576.7 | |
| All* | Total formula weight | 45434.8 |
