5L0Q
Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D | Disintegrin and metalloproteinase domain-containing protein 10 | polymer | 203 | 21780.7 | 2 | UniProt (Q10741) Pfam (PF00200) Pfam (PF21299) In PDB | Bos taurus (Bovine) | ADAM 10,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease,Myelin-associated metalloproteinase |
| 2 | B, E | mAb 8C7 light chain | polymer | 214 | 23712.1 | 2 | Homo sapiens | ||
| 3 | C, F | mAb 8C7 heavy chain | polymer | 222 | 23930.7 | 2 | Homo sapiens | ||
| 4 | A, C, D, F | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | A, B, C, D, E... | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 6 | A, D | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | water | water | 18.0 | 334 | Chemie (HOH) |
Sequence modifications
A, D: 455 - 646 (UniProt: Q10741)
| PDB | External Database | Details |
|---|---|---|
| Pro 450 | - | expression tag |
| Val 451 | - | expression tag |
| Gly 452 | - | expression tag |
| Leu 453 | - | expression tag |
| Ala 454 | - | expression tag |
| Gly 647 | - | expression tag |
| Ser 648 | - | expression tag |
| Ala 649 | - | expression tag |
| Ser 650 | - | expression tag |
| Gly 651 | - | expression tag |
| Leu 652 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 138847.1 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2182.3 | |
| All* | Total formula weight | 141029.3 |
