5L0Q

Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006509	biological_process	membrane protein ectodomain proteolysis
A	0007219	biological_process	Notch signaling pathway
D	0004222	molecular_function	metalloendopeptidase activity
D	0006509	biological_process	membrane protein ectodomain proteolysis
D	0007219	biological_process	Notch signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	188
Details	Domain: {"description":"Disintegrin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00068","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PDB","id":"5L0Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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