5KZY

Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with cyclopamine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Smoothened	polymer	121	13402.4	2	UniProt (Q98SW5) Pfam (PF01392)	Xenopus laevis (African clawed frog)
2	C, D (A, B)	Cyclopamine	non-polymer		411.6	2	Chemie (CY8) PubChem (20518) PubChem (4113848) PubChem (6325009) PubChem (9844520) PubChem (16760050) PubChem (16760382) PubChem (23651259) PubChem (23919695) PubChem (37818581) PubChem (37818584) PubChem (44593473) PubChem (176519873) PubChem (46783360) PubChem (40619433) PubChem (44118238) PubChem (57519537) PubChem (58185650) PubChem (58885159) PubChem (143567069) PubChem (442972) PubChem (86287406) PubChem (91654170) PubChem (92311543) PubChem (92311439) PubChem (5316548) PubChem (124835765) PubChem (126660112) PubChem (134694700) PubChem (58682623) PubChem (58885171) PubChem (66577043) PubChem (67477143) PubChem (73440807) PubChem (92311443) PubChem (92311544) PubChem (102004827) PubChem (117758465) PubChem (118983942) PubChem (121271016) PubChem (122130428) PubChem (124835762) PubChem (124835763) PubChem (124835764) PubChem (126660312) PubChem (129375254) PubChem (129606911) PubChem (131700441) PubChem (133687897) PubChem (134336480) PubChem (134852210) PubChem (137704777) PubChem (138756127) PubChem (144152952) PubChem (155196952) PubChem (160363420) PubChem (163101895) PubChem (163101896) PubChem (163284919) PubChem (163889965) PubChem (172897585)
3	E, F (A, B)	water	water		18.0	45	Chemie (HOH)

Sequence modifications

A, B: 35 - 154 (UniProt: Q98SW5)

PDB	External Database	Details
Gly 34	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	26804.8
Non-Polymers*	Number of molecules	2
	Total formula weight	823.2
All*	Total formula weight	27628.0

*Water molecules are not included.