5KZY
Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with cyclopamine
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue CY8 A 1201 |
| Chain | Residue |
| A | ASP68 |
| A | LYS78 |
| A | TRP82 |
| A | GLY84 |
| A | LEU85 |
| A | ILE129 |
| A | VAL130 |
| A | ARG134 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue CY8 B 1201 |
| Chain | Residue |
| B | LEU81 |
| B | TRP82 |
| B | GLY84 |
| B | LEU85 |
| B | ILE129 |
| B | ARG134 |
| B | ASP68 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27545348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29804838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D35","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"Cholesterol aspartate ester","evidences":[{"source":"UniProtKB","id":"Q99835","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
