5KWY
Structure of human NPC1 middle lumenal domain bound to NPC2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Niemann-Pick C1 protein | polymer | 247 | 28234.2 | 2 | UniProt (O15118) Pfam (PF22314) | Homo sapiens (Human) | |
| 2 | C, D (C, D) | Epididymal secretory protein E1 | polymer | 133 | 14663.8 | 2 | UniProt (P61916) Pfam (PF02221) | Homo sapiens (Human) | Human epididymis-specific protein 1,He1,Niemann-Pick disease type C2 protein |
| 3 | E, F, H, I (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | G, J (C, D) | CHOLEST-5-EN-3-YL HYDROGEN SULFATE | non-polymer | 466.7 | 2 | Chemie (C3S) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence modifications
C, D: 20 - 151 (UniProt: P61916)
| PDB | External Database | Details |
|---|---|---|
| Ala 152 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 85796.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1818.3 | |
| All* | Total formula weight | 87614.4 |
