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5KWY

Structure of human NPC1 middle lumenal domain bound to NPC2

Functional Information from GO Data
ChainGOidnamespacecontents
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005764cellular_componentlysosome
C0005783cellular_componentendoplasmic reticulum
C0006869biological_processlipid transport
C0008203biological_processcholesterol metabolic process
C0009615biological_processresponse to virus
C0010467biological_processgene expression
C0010878biological_processcholesterol storage
C0015485molecular_functioncholesterol binding
C0015914biological_processphospholipid transport
C0015918biological_processsterol transport
C0016125biological_processsterol metabolic process
C0019747biological_processregulation of isoprenoid metabolic process
C0019899molecular_functionenzyme binding
C0030301biological_processcholesterol transport
C0032366biological_processintracellular sterol transport
C0032367biological_processintracellular cholesterol transport
C0032934molecular_functionsterol binding
C0033344biological_processcholesterol efflux
C0035578cellular_componentazurophil granule lumen
C0042632biological_processcholesterol homeostasis
C0043202cellular_componentlysosomal lumen
C0046836biological_processglycolipid transport
C0070062cellular_componentextracellular exosome
C0120020molecular_functioncholesterol transfer activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005764cellular_componentlysosome
D0005783cellular_componentendoplasmic reticulum
D0006869biological_processlipid transport
D0008203biological_processcholesterol metabolic process
D0009615biological_processresponse to virus
D0010467biological_processgene expression
D0010878biological_processcholesterol storage
D0015485molecular_functioncholesterol binding
D0015914biological_processphospholipid transport
D0015918biological_processsterol transport
D0016125biological_processsterol metabolic process
D0019747biological_processregulation of isoprenoid metabolic process
D0019899molecular_functionenzyme binding
D0030301biological_processcholesterol transport
D0032366biological_processintracellular sterol transport
D0032367biological_processintracellular cholesterol transport
D0032934molecular_functionsterol binding
D0033344biological_processcholesterol efflux
D0035578cellular_componentazurophil granule lumen
D0042632biological_processcholesterol homeostasis
D0043202cellular_componentlysosomal lumen
D0046836biological_processglycolipid transport
D0070062cellular_componentextracellular exosome
D0120020molecular_functioncholesterol transfer activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9Z0J0
ChainResidueDetails
CLYS116
DLYS116
BASN452
BASN459

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17018531, ECO:0000269|PubMed:27551080, ECO:0007744|PDB:5KWY
ChainResidueDetails
CASN58
DASN58
BASN478
BASN557

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17018531, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:27551080, ECO:0007744|PDB:5KWY
ChainResidueDetails
CASN135
DASN135

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26846330, ECO:0000269|PubMed:27238017, ECO:0007744|PDB:3JD8, ECO:0007744|PDB:5HNS
ChainResidueDetails
AASN572
BASN572

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26846330, ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28784760, ECO:0007744|PDB:3JD8, ECO:0007744|PDB:5HNS, ECO:0007744|PDB:5U74
ChainResidueDetails
AASN598
BASN598

224572

PDB entries from 2024-09-04

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