5KWY
Structure of human NPC1 middle lumenal domain bound to NPC2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0005319 | molecular_function | lipid transporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005764 | cellular_component | lysosome |
| C | 0005770 | cellular_component | late endosome |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0009615 | biological_process | response to virus |
| C | 0015485 | molecular_function | cholesterol binding |
| C | 0015914 | biological_process | phospholipid transport |
| C | 0015918 | biological_process | sterol transport |
| C | 0019747 | biological_process | regulation of isoprenoid metabolic process |
| C | 0019899 | molecular_function | enzyme binding |
| C | 0030301 | biological_process | cholesterol transport |
| C | 0032366 | biological_process | intracellular sterol transport |
| C | 0032367 | biological_process | intracellular cholesterol transport |
| C | 0032934 | molecular_function | sterol binding |
| C | 0033344 | biological_process | cholesterol efflux |
| C | 0035578 | cellular_component | azurophil granule lumen |
| C | 0042632 | biological_process | cholesterol homeostasis |
| C | 0043202 | cellular_component | lysosomal lumen |
| C | 0046836 | biological_process | glycolipid transport |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0090120 | biological_process | lysosome to ER cholesterol transport |
| C | 0120020 | molecular_function | cholesterol transfer activity |
| D | 0005319 | molecular_function | lipid transporter activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005764 | cellular_component | lysosome |
| D | 0005770 | cellular_component | late endosome |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0009615 | biological_process | response to virus |
| D | 0015485 | molecular_function | cholesterol binding |
| D | 0015914 | biological_process | phospholipid transport |
| D | 0015918 | biological_process | sterol transport |
| D | 0019747 | biological_process | regulation of isoprenoid metabolic process |
| D | 0019899 | molecular_function | enzyme binding |
| D | 0030301 | biological_process | cholesterol transport |
| D | 0032366 | biological_process | intracellular sterol transport |
| D | 0032367 | biological_process | intracellular cholesterol transport |
| D | 0032934 | molecular_function | sterol binding |
| D | 0033344 | biological_process | cholesterol efflux |
| D | 0035578 | cellular_component | azurophil granule lumen |
| D | 0042632 | biological_process | cholesterol homeostasis |
| D | 0043202 | cellular_component | lysosomal lumen |
| D | 0046836 | biological_process | glycolipid transport |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0090120 | biological_process | lysosome to ER cholesterol transport |
| D | 0120020 | molecular_function | cholesterol transfer activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z0J0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17018531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27551080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KWY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17018531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27551080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KWY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
