5KR7

KDM4C bound to pyrazolo-pyrimidine scaffold

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Lysine-specific demethylase 4C	polymer	367	42337.3	2	UniProt (Q9H3R0) Pfam (PF02375) Pfam (PF02373) In PDB	Homo sapiens (Human)	Gene amplified in squamous cell carcinoma 1 protein,GASC-1 protein,JmjC domain-containing histone demethylation protein 3C,Jumonji domain-containing protein 2C
2	A, B	FE (II) ION	non-polymer		55.8	2	Chemie (FE2)
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	A, B	6-ethyl-2,5-dimethyl-7-oxidanylidene-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile	non-polymer		216.2	2	Chemie (6X9)
5	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6		water	water		18.0	415	Chemie (HOH)

Sequence modifications

A, B: 1 - 350 (UniProt: Q9H3R0)

PDB	External Database	Details
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
Met -13	-	expression tag
Ala -12	-	expression tag
Ser -11	-	expression tag
Met -10	-	expression tag
Thr -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gln -6	-	expression tag
Gln -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84674.5
Non-Polymers*	Number of molecules	8
	Total formula weight	745.9
All*	Total formula weight	85420.4

*Water molecules are not included.