5KKL
Structure of ctPRC2 in complex with H3K27me3 and H3K27M
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | putative polycomb protein Eed | polymer | 605 | 66021.4 | 1 | UniProt (G0S8H7) Pfam (PF00400) Pfam (PF22038) | Chaetomium thermophilum | |
| 2 | B (B) | Putative uncharacterized protein,Histone H3.1 peptide,Zinc finger domain-containing protein | polymer | 938 | 106890.6 | 1 | UniProt (G0SDW4) UniProt (P68431) UniProt (G0RYC6) Pfam (PF18601) Pfam (PF18600) Pfam (PF21509) Pfam (PF00856) Pfam (PF09733) | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) | |
| 3 | C (D) | ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA | polymer | 11 | 1146.4 | 1 | UniProt (by SIFTS) (P68431) | Homo sapiens | |
| 4 | D, E, F, G, H... (B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 5 | L (B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (9865603) PubChem (145712080) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) |
Sequence modifications
A: 1 - 565 (UniProt: G0S8H7)
B: 191 - 2013 (UniProt: G0SDW4)
B: 2022 - 2030 (UniProt: P68431)
B: 2031 - 2691 (UniProt: G0RYC6)
| PDB | External Database | Details |
|---|---|---|
| Met -39 | - | expression tag |
| Ala -38 | - | expression tag |
| Ser -37 | - | expression tag |
| Ala -36 | - | expression tag |
| Trp -35 | - | expression tag |
| Ser -34 | - | expression tag |
| His -33 | - | expression tag |
| Pro -32 | - | expression tag |
| Gln -31 | - | expression tag |
| Phe -30 | - | expression tag |
| Glu -29 | - | expression tag |
| Lys -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Gly -25 | - | expression tag |
| Ser -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Ser -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ala -16 | - | expression tag |
| Trp -15 | - | expression tag |
| Ser -14 | - | expression tag |
| His -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Gln -11 | - | expression tag |
| Phe -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 182 | - | expression tag |
| Asn 183 | - | expression tag |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| Ala 190 | - | expression tag |
| Leu 2014 | - | linker |
| Val 2015 | - | linker |
| Pro 2016 | - | linker |
| Ala 2017 | - | linker |
| Gly 2018 | - | linker |
| Ser 2019 | - | linker |
| Glu 2020 | - | linker |
| Val 2021 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Met 2027 | Lys 28 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 174058.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 921.7 | |
| All* | Total formula weight | 174980.0 |
