5K5S
Crystal structure of the active form of human calcium-sensing receptor extracellular domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Extracellular calcium-sensing receptor | polymer | 615 | 69241.6 | 2 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) In PDB | Homo sapiens (Human) | CaSR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
2 | A, B | TRYPTOPHAN | non-polymer | 204.2 | 2 | Chemie (TRP) | |||
3 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
4 | A, B | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
6 | water | water | 18.0 | 331 | Chemie (HOH) |
Sequence modifications
A, B: 20 - 607 (UniProt: P41180)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ala 2 | - | expression tag |
Phe 3 | - | expression tag |
Tyr 4 | - | expression tag |
Ser 5 | - | expression tag |
Cys 6 | - | expression tag |
Cys 7 | - | expression tag |
Trp 8 | - | expression tag |
Val 9 | - | expression tag |
Leu 10 | - | expression tag |
Leu 11 | - | expression tag |
Ala 12 | - | expression tag |
Leu 13 | - | expression tag |
Thr 14 | - | expression tag |
Trp 15 | - | expression tag |
His 16 | - | expression tag |
Thr 17 | - | expression tag |
Ser 18 | - | expression tag |
Ala 19 | - | expression tag |
Gln 386 | Asn 386 | engineered mutation |
Asn 402 | Ser 402 | engineered mutation |
Gln 468 | Asn 468 | engineered mutation |
Asp 608 | - | expression tag |
Tyr 609 | - | expression tag |
Lys 610 | - | expression tag |
Asp 611 | - | expression tag |
Asp 612 | - | expression tag |
Asp 613 | - | expression tag |
Asp 614 | - | expression tag |
Lys 615 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 138483.3 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 2215.0 | |
All* | Total formula weight | 140698.3 |