5K5S

Crystal structure of the active form of human calcium-sensing receptor extracellular domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Extracellular calcium-sensing receptor	polymer	615	69241.6	2	UniProt (P41180) Pfam (PF01094) Pfam (PF07562)	Homo sapiens (Human)	CaSR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2	C, O (A, B)	TRYPTOPHAN	non-polymer		204.2	2	Chemie (TRP)
3	D, E, P, Q (A, B)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
4	F, G, H, I, N... (A, B)	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
5	J, K, L, M, U (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
6	V, W (A, B)	water	water		18.0	331	Chemie (HOH)

Sequence modifications

A, B: 20 - 607 (UniProt: P41180)

PDB	External Database	Details
Met 1	-	initiating methionine
Ala 2	-	expression tag
Phe 3	-	expression tag
Tyr 4	-	expression tag
Ser 5	-	expression tag
Cys 6	-	expression tag
Cys 7	-	expression tag
Trp 8	-	expression tag
Val 9	-	expression tag
Leu 10	-	expression tag
Leu 11	-	expression tag
Ala 12	-	expression tag
Leu 13	-	expression tag
Thr 14	-	expression tag
Trp 15	-	expression tag
His 16	-	expression tag
Thr 17	-	expression tag
Ser 18	-	expression tag
Ala 19	-	expression tag
Gln 386	Asn 386	engineered mutation
Asn 402	Ser 402	engineered mutation
Gln 468	Asn 468	engineered mutation
Asp 608	-	expression tag
Tyr 609	-	expression tag
Lys 610	-	expression tag
Asp 611	-	expression tag
Asp 612	-	expression tag
Asp 613	-	expression tag
Asp 614	-	expression tag
Lys 615	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	138483.3
Non-Polymers*	Number of molecules	19
	Total formula weight	2215.0
All*	Total formula weight	140698.3

*Water molecules are not included.