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5K5S

Crystal structure of the active form of human calcium-sensing receptor extracellular domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
B0004930molecular_functionG protein-coupled receptor activity
B0007186biological_processG protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLgLFyIPQVSyASSS
ChainResidueDetails
AVAL153-SER171

site_idPS00980
Number of Residues25
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCFeCveCpdgeYsdet.DasACnkC
ChainResidueDetails
ACYS561-CYS585

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5K5S
ChainResidueDetails
AARG66
BASP234
BARG415
BGLY557
ATHR145
AGLU231
AASP234
AARG415
AGLY557
BARG66
BTHR145
BGLU231

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0000305|PubMed:27386547, ECO:0007744|PDB:5FBH, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S
ChainResidueDetails
AILE81
ALEU87
ALEU88
BILE81
BLEU87
BLEU88

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0000305|PubMed:27386547, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S
ChainResidueDetails
ASER84
BSER84

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5K5S, ECO:0007744|PDB:5K5T
ChainResidueDetails
ATHR100
BTHR100

site_idSWS_FT_FI5
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5FBH, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S
ChainResidueDetails
ASER147
AALA168
ASER170
AGLU297
BSER147
BALA168
BSER170
BGLU297

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Important for ability of agonist AMG 416 to activate G-protein-coupled receptor activity => ECO:0000269|PubMed:26290606
ChainResidueDetails
ACYS482
BCYS482

site_idSWS_FT_FI7
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN90
AASN130
AGLN386
AASN400
BASN90
BASN130
BGLN386
BASN400

site_idSWS_FT_FI8
Number of Residues14
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:27434672
ChainResidueDetails
AASN261
BASN446
BGLN468
BASN488
BASN541
BASN594
AASN287
AASN446
AGLN468
AASN488
AASN541
AASN594
BASN261
BASN287

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PDB entries from 2024-11-06

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