5K5S
Crystal structure of the active form of human calcium-sensing receptor extracellular domain
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004930 | molecular_function | G protein-coupled receptor activity |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0016020 | cellular_component | membrane |
B | 0004930 | molecular_function | G protein-coupled receptor activity |
B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
B | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
site_id | PS00979 |
Number of Residues | 19 |
Details | G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLgLFyIPQVSyASSS |
Chain | Residue | Details |
A | VAL153-SER171 |
site_id | PS00980 |
Number of Residues | 25 |
Details | G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCFeCveCpdgeYsdet.DasACnkC |
Chain | Residue | Details |
A | CYS561-CYS585 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5K5S |
Chain | Residue | Details |
A | ARG66 | |
B | ASP234 | |
B | ARG415 | |
B | GLY557 | |
A | THR145 | |
A | GLU231 | |
A | ASP234 | |
A | ARG415 | |
A | GLY557 | |
B | ARG66 | |
B | THR145 | |
B | GLU231 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0000305|PubMed:27386547, ECO:0007744|PDB:5FBH, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S |
Chain | Residue | Details |
A | ILE81 | |
A | LEU87 | |
A | LEU88 | |
B | ILE81 | |
B | LEU87 | |
B | LEU88 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0000305|PubMed:27386547, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S |
Chain | Residue | Details |
A | SER84 | |
B | SER84 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5K5S, ECO:0007744|PDB:5K5T |
Chain | Residue | Details |
A | THR100 | |
B | THR100 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5FBH, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S |
Chain | Residue | Details |
A | SER147 | |
A | ALA168 | |
A | SER170 | |
A | GLU297 | |
B | SER147 | |
B | ALA168 | |
B | SER170 | |
B | GLU297 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Important for ability of agonist AMG 416 to activate G-protein-coupled receptor activity => ECO:0000269|PubMed:26290606 |
Chain | Residue | Details |
A | CYS482 | |
B | CYS482 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN90 | |
A | ASN130 | |
A | GLN386 | |
A | ASN400 | |
B | ASN90 | |
B | ASN130 | |
B | GLN386 | |
B | ASN400 |
site_id | SWS_FT_FI8 |
Number of Residues | 14 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:27434672 |
Chain | Residue | Details |
A | ASN261 | |
B | ASN446 | |
B | GLN468 | |
B | ASN488 | |
B | ASN541 | |
B | ASN594 | |
A | ASN287 | |
A | ASN446 | |
A | GLN468 | |
A | ASN488 | |
A | ASN541 | |
A | ASN594 | |
B | ASN261 | |
B | ASN287 |