Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5K0Y

m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (N)	tRNA	polymer	75	24231.5	1		Oryctolagus cuniculus (Rabbit)
2	B (A)	18S ribosomal RNA	polymer	1776	572789.8	1		Oryctolagus cuniculus (Rabbit)
3	C (F)	mRNA	polymer	30	9603.8	1		Oryctolagus cuniculus (Rabbit)
4	D (P)	Eukaryotic translation initiation factor 2 subunit 1	polymer	266	30633.3	1	UniProt (G1T2G4) Pfam (PF00575) Pfam (PF07541)	Oryctolagus cuniculus (Rabbit)
5	E (G)	ribosomal protein uS17	polymer	158	18468.8	1	UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366)	Oryctolagus cuniculus (Rabbit)
6	F (H)	ribosomal protein uS9	polymer	141	15975.8	1	UniProt (G1SGX4) Pfam (PF00380)	Oryctolagus cuniculus (Rabbit)
7	G (I)	40S ribosomal protein S4	polymer	263	29658.9	1	UniProt (G1TK17) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121)	Oryctolagus cuniculus (Rabbit)
8	H (J)	ribosomal protein uS14	polymer	53	6364.4	1	UniProt (G1U7M4) Pfam (PF00253)	Oryctolagus cuniculus (Rabbit)
9	I (K)	Ribosomal protein S9 (Predicted)	polymer	182	21266.2	1	UniProt (B7NZS8) Pfam (PF01479) Pfam (PF00163)	Oryctolagus cuniculus (Rabbit)
10	J (L)	ribosomal protein uS13	polymer	137	16170.8	1	UniProt (G1TPG3) Pfam (PF00416)	Oryctolagus cuniculus (Rabbit)
11	K (M)	Eukaryotic translation initiation factor 3 subunit G	polymer	38	4124.5	1	UniProt (O75821) Pfam (PF12353)	Homo sapiens (Human)	eIF3g,Eukaryotic translation initiation factor 3 RNA-binding subunit,eIF-3 RNA-binding subunit,Eukaryotic translation initiation factor 3 subunit 4,eIF-3-delta,eIF3 p42,eIF3 p44
12	L (O)	Eukaryotic translation initiation factor 3 subunit G	polymer	77	8675.7	1	UniProt (O75821) Pfam (PF00076)	Homo sapiens (Human)	eIF3g,Eukaryotic translation initiation factor 3 RNA-binding subunit,eIF-3 RNA-binding subunit,Eukaryotic translation initiation factor 3 subunit 4,eIF-3-delta,eIF3 p42,eIF3 p44
13	M (Q)	ribosomal protein uS12	polymer	142	15757.6	1	Pfam (PF00164) UniProt (by SIFTS) (G1SZ47)	Oryctolagus cuniculus (Rabbit)
14	N (R)	ribosomal protein eS19	polymer	141	15812.3	1	UniProt (G1TN62) Pfam (PF01090)	Oryctolagus cuniculus (Rabbit)
15	O (S)	eukaryotic initiation factor 2 Gamma subunit (eIF2-Gamma)	polymer	422	45862.4	1	Pfam (PF00009) Pfam (PF03144) Pfam (PF09173) UniProt (by SIFTS) (G1SRA8)	Oryctolagus cuniculus (Rabbit)
16	P (T)	Eukaryotic translation initiation factor 3 subunit I	polymer	329	37039.3	1	UniProt (Q5IH81) Pfam (PF24805)	Oryctolagus cuniculus (Rabbit)	eIF3i,Eukaryotic translation initiation factor 3 subunit 2,eIF-3-beta,eIF3 p36
17	Q (U)	ribosomal protein uS7	polymer	191	21525.9	1	UniProt (G1TFM5) Pfam (PF00177) UniProt (by SIFTS) (U3KMN4)	Oryctolagus cuniculus (Rabbit)
18	R (V)	ribosomal protein eS30	polymer	59	6741.0	1	UniProt (G1T8A2) Pfam (PF04758)	Oryctolagus cuniculus (Rabbit)
19	S (W)	ribosomal protein eS25	polymer	75	8526.1	1	UniProt (G1TDB3) Pfam (PF03297)	Oryctolagus cuniculus (Rabbit)
20	T (X)	ribosomal protein eS7	polymer	190	21716.4	1	UniProt (G1SVB0) Pfam (PF01251)	Oryctolagus cuniculus (Rabbit)
21	U (Y)	40S ribosomal protein S27	polymer	84	9480.2	1	UniProt (G1TZ76) Pfam (PF01667)	Oryctolagus cuniculus (Rabbit)
22	V (Z)	ribosomal protein uS15	polymer	150	17128.2	1	UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312)	Oryctolagus cuniculus (Rabbit)
23	W (a)	ribosomal protein uS8	polymer	129	14734.4	1	UniProt (G1TG89) Pfam (PF00410)	Oryctolagus cuniculus (Rabbit)
24	X (b)	40S ribosomal protein S21	polymer	82	8896.1	1	UniProt (G1TM82) Pfam (PF01249)	Oryctolagus cuniculus (Rabbit)
25	Y (c)	ribosomal protein uS5	polymer	226	24814.3	1		Oryctolagus cuniculus
26	Z (d)	eukaryotic initiation factor 2 subunit Beta (eIF2-Beta)	polymer	17	2103.4	1	UniProt (by SIFTS) (Q97W59)	Oryctolagus cuniculus
27	AA (e)	ribosomal protein eS17	polymer	126	14579.0	1	UniProt (G1TU13) Pfam (PF00833)	Oryctolagus cuniculus (Rabbit)
28	BA (f)	ribosomal protein uS2	polymer	208	23360.8	1	Pfam (PF00318) UniProt (by SIFTS) (G1TLT8)	Oryctolagus cuniculus
29	CA (g)	ribosomal protein uS3	polymer	227	25158.5	1	Pfam (PF07650) Pfam (PF00189) UniProt (by SIFTS) (G1TNM3)	Oryctolagus cuniculus
30	DA (h)	ribosomal protein uS10	polymer	104	11765.9	1	Pfam (PF00338) UniProt (by SIFTS) (G1SIZ2)	Oryctolagus cuniculus
31	EA (i)	ribosomal protein eS1	polymer	215	24944.4	1	UniProt (G1TN72) Pfam (PF01015)	Oryctolagus cuniculus (Rabbit)
32	FA (j)	ribosomal protein uS11	polymer	136	14544.7	1	Pfam (PF00411) UniProt (by SIFTS) (G1T1F0)	Oryctolagus cuniculus
33	GA (k)	ribosomal protein eS26	polymer	99	11315.4	1	UniProt (G1TFE8) Pfam (PF01283)	Oryctolagus cuniculus (Rabbit)
34	HA (l)	ribosomal protein eS28	polymer	64	7263.4	1	UniProt (G1TIB4) Pfam (PF01200)	Oryctolagus cuniculus (Rabbit)
35	IA (m)	ribosomal protein RACK1	polymer	313	34669.1	1	UniProt (G1SJB4) Pfam (PF00400)	Oryctolagus cuniculus (Rabbit)
36	JA (n)	ribosomal protein uS19	polymer	127	15151.9	1	UniProt (G1U0Q2) Pfam (PF00203)	Oryctolagus cuniculus (Rabbit)
37	KA (o)	40S ribosomal protein S8	polymer	206	23902.9	1	UniProt (G1TJW1) Pfam (PF01201)	Oryctolagus cuniculus (Rabbit)
38	LA (p)	ribosomal protein eS31	polymer	71	8358.9	1	UniProt (G1SK22) Pfam (PF01599)	Oryctolagus cuniculus (Rabbit)
39	MA (q)	40S ribosomal protein S6	polymer	237	27471.5	1	UniProt (G1TM55) Pfam (PF01092)	Oryctolagus cuniculus (Rabbit)
40	NA (r)	40S ribosomal protein S12	polymer	124	13766.1	1	UniProt (G1SFR8) Pfam (PF01248)	Oryctolagus cuniculus (Rabbit)
41	OA (s)	40S ribosomal protein S24	polymer	131	15189.0	1	UniProt (G1TS40) Pfam (PF01282) UniProt (by SIFTS) (A0A5F9D2E6)	Oryctolagus cuniculus (Rabbit)
42	PA (t)	ribosomal protein eS10	polymer	98	11774.0	1	UniProt (G1TPV3) Pfam (PF03501) UniProt (by SIFTS) (G1T168)	Oryctolagus cuniculus (Rabbit)

Sequence modifications

N: 1 - 72 (GENBANK: 655840029)

PDB	External Database	Details
C 73	-	expression tag
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A 75	-	expression tag

A: 761 - 1863 (GENBANK: 283837872)

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G 616	-	expression tag
U 617	-	expression tag
A 618	-	expression tag
A 619	-	expression tag
U 620	-	expression tag
U 621	-	expression tag
C 622	-	expression tag
C 623	-	expression tag
A 624	-	expression tag
G 625	-	expression tag
C 626	-	expression tag
U 627	-	expression tag
C 628	-	expression tag
C 629	-	expression tag
A 630	-	expression tag
A 631	-	expression tag
U 632	-	expression tag
A 633	-	expression tag
G 634	-	expression tag
C 635	-	expression tag
G 636	-	expression tag
U 637	-	expression tag
A 638	-	expression tag
U 639	-	expression tag
A 640	-	expression tag
U 641	-	expression tag
U 642	-	expression tag
A 643	-	expression tag
A 644	-	expression tag
A 645	-	expression tag
G 646	-	expression tag
U 647	-	expression tag
U 648	-	expression tag
G 649	-	expression tag
C 650	-	expression tag
U 651	-	expression tag
G 652	-	expression tag
C 653	-	expression tag
A 654	-	expression tag
G 655	-	expression tag
U 656	-	expression tag
U 657	-	expression tag
A 658	-	expression tag
A 659	-	expression tag
A 660	-	expression tag
A 661	-	expression tag
A 662	-	expression tag
G 663	-	expression tag
C 664	-	expression tag
U 665	-	expression tag
C 666	-	expression tag
G 667	-	expression tag
U 668	-	expression tag
A 669	-	expression tag
G 670	-	expression tag
U 671	-	expression tag
U 672	-	expression tag
G 673	-	expression tag
G 674	-	expression tag
A 675	-	expression tag
U 676	-	expression tag
C 677	-	expression tag
U 678	-	expression tag
U 679	-	expression tag
G 683	-	expression tag
A 684	-	expression tag
G 685	-	expression tag
G 686	-	expression tag
G 687	-	expression tag
C 730	-	expression tag
C 731	-	expression tag
C 732	-	expression tag
G 733	-	expression tag
C 734	-	expression tag
C 735	-	expression tag
C 736	-	expression tag
C 744	-	expression tag
U 745	-	expression tag
C 746	-	expression tag
G 747	-	expression tag
G 748	-	expression tag
C 749	-	expression tag
G 750	-	expression tag
C 751	-	expression tag
C 752	-	expression tag
C 753	-	expression tag
C 754	-	expression tag
C 755	-	expression tag
U 756	-	expression tag
C 757	-	expression tag
G 758	-	expression tag
A 759	-	expression tag
U 760	-	expression tag

Sequence viewer

Contents of the asymmetric unit

Polymers	Number of chains	42
Polymers	Total formula weight	1291316.6
All*	Total formula weight	1291316.6

*Water molecules are not included.

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)