5JO3
PDE5A for NaV1.7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 326 | 37610.2 | 1 | UniProt (O76074) Pfam (PF00233) In PDB | Homo sapiens (Human) | cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE |
| 2 | B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | B | 1-(5-chloro-6-methoxypyridin-3-yl)-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide | non-polymer | 394.8 | 1 | Chemie (6LK) | |||
| 4 | water | water | 18.0 | 367 | Chemie (HOH) |
Sequence modifications
B: 534 - 858 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Pro 658 | Arg 658 | conflict |
| Ser 661 | Asn 661 | conflict |
| Gln 663 | Ser 663 | conflict |
| Phe 664 | Tyr 664 | conflict |
| Leu 665 | Ile 665 | conflict |
| Ile 666 | Gln 666 | conflict |
| Asn 667 | Arg 667 | conflict |
| Thr 668 | Ser 668 | conflict |
| Asn 669 | Glu 669 | conflict |
| Ser 670 | His 670 | conflict |
| Glu 671 | Pro 671 | conflict |
| Leu 674 | Gln 674 | conflict |
| Met 675 | Leu 675 | conflict |
| Asn 677 | - | insertion |
| Asp 678 | Cys 677 | conflict |
| Glu 679 | His 678 | conflict |
| Val 681 | Ile 680 | conflict |
| Leu 681 | Met 681 | conflict |
| Glu 751 | Gln 751 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37610.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 525.7 | |
| All* | Total formula weight | 38135.9 |
