5JO3
PDE5A for NaV1.7
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 901 |
| Chain | Residue |
| B | HIS617 |
| B | HIS653 |
| B | ASP654 |
| B | ASP764 |
| B | HOH1041 |
| B | HOH1086 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 902 |
| Chain | Residue |
| B | HOH1086 |
| B | HOH1120 |
| B | HOH1172 |
| B | ASP654 |
| B | HOH1027 |
| B | HOH1029 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 6LK B 903 |
| Chain | Residue |
| B | LEU765 |
| B | ALA767 |
| B | ILE768 |
| B | GLN775 |
| B | ALA779 |
| B | LEU804 |
| B | MET816 |
| B | GLN817 |
| B | PHE820 |
| B | HOH1107 |
| B | HOH1196 |
| B | HOH1270 |
| B | HOH1300 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGvsNqF |
| Chain | Residue | Details |
| B | HIS653-PHE664 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
