5ITX
Crystal Structure of Human NEIL1(P2G R242K) bound to duplex DNA containing Thymine Glycol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Endonuclease 8-like 1 | polymer | 390 | 43756.1 | 2 | UniProt (Q96FI4) Pfam (PF01149) Pfam (PF09292) | Homo sapiens (Human) | DNA glycosylase/AP lyase Neil1,DNA-(apurinic or apyrimidinic site) lyase Neil1,Endonuclease VIII-like 1,FPG1,Nei homolog 1,NEH1,Nei-like protein 1 |
| 2 | B, D, F (D, C, F) | DNA (26-MER) | polymer | 26 | 7998.1 | 3 | unidentified | ||
| 3 | E (E) | Endonuclease 8-like 1 | polymer | 400 | 44885.3 | 1 | UniProt (Q96FI4) Pfam (PF01149) Pfam (PF09292) | Homo sapiens (Human) | DNA glycosylase/AP lyase Neil1,DNA-(apurinic or apyrimidinic site) lyase Neil1,Endonuclease VIII-like 1,FPG1,Nei homolog 1,NEH1,Nei-like protein 1 |
| 4 | G, H, I, J, K... (A, D, B, C, E...) | water | water | 18.0 | 183 | Chemie (HOH) |
Sequence modifications
E: 1 - 390 (UniProt: Q96FI4)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | Pro 2 | engineered mutation |
| Arg 242 | Lys 242 | engineered mutation |
| Ala 391 | - | expression tag |
| Ala 392 | - | expression tag |
| Leu 393 | - | expression tag |
| Gly 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 156392.0 | |
| All* | Total formula weight | 156392.0 |
