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5ITX

Crystal Structure of Human NEIL1(P2G R242K) bound to duplex DNA containing Thymine Glycol

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003824molecular_functioncatalytic activity
A0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006287biological_processbase-excision repair, gap-filling
A0006974biological_processDNA damage response
A0006979biological_processresponse to oxidative stress
A0008270molecular_functionzinc ion binding
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
A0016829molecular_functionlyase activity
A0019104molecular_functionDNA N-glycosylase activity
A0032074biological_processnegative regulation of nuclease activity
A0045008biological_processdepyrimidination
A0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0003824molecular_functioncatalytic activity
B0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006281biological_processDNA repair
B0006284biological_processbase-excision repair
B0006287biological_processbase-excision repair, gap-filling
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0008270molecular_functionzinc ion binding
B0016787molecular_functionhydrolase activity
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
B0016829molecular_functionlyase activity
B0019104molecular_functionDNA N-glycosylase activity
B0032074biological_processnegative regulation of nuclease activity
B0045008biological_processdepyrimidination
B0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
E0003676molecular_functionnucleic acid binding
E0003677molecular_functionDNA binding
E0003684molecular_functiondamaged DNA binding
E0003824molecular_functioncatalytic activity
E0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0006281biological_processDNA repair
E0006284biological_processbase-excision repair
E0006287biological_processbase-excision repair, gap-filling
E0006974biological_processDNA damage response
E0006979biological_processresponse to oxidative stress
E0008270molecular_functionzinc ion binding
E0016787molecular_functionhydrolase activity
E0016798molecular_functionhydrolase activity, acting on glycosyl bonds
E0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
E0016829molecular_functionlyase activity
E0019104molecular_functionDNA N-glycosylase activity
E0032074biological_processnegative regulation of nuclease activity
E0045008biological_processdepyrimidination
E0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Schiff-base intermediate with DNA => ECO:0000305
ChainResidueDetails
EGLY2
BPRO2

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000305
ChainResidueDetails
EGLU3
BGLU3

site_idSWS_FT_FI3
Number of Residues1
DetailsACT_SITE: Proton donor; for beta-elimination activity => ECO:0000305
ChainResidueDetails
ELYS54
BLYS54

site_idSWS_FT_FI4
Number of Residues1
DetailsACT_SITE: Proton donor; for delta-elimination activity => ECO:0000305
ChainResidueDetails
EARG339
BARG339

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
EASN176
EARG339
BASN176
BARG339

237423

PDB entries from 2025-06-11

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