5HYS

Structure of IgE complexed with omalizumab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (H, A, C, E)	Epididymis luminal protein 214	polymer	222	23653.4	4		Homo sapiens (Human)
2	B, D, F, H (L, B, D, F)	Uncharacterized protein	polymer	218	23922.3	4		Homo sapiens (Human)
3	I, J, K, L (G, I, J, K)	Ig epsilon chain C region	polymer	230	25637.8	4	UniProt (P01854) Pfam (PF07654)	Homo sapiens (Human)
4	M, N, O, P (M, N, O, P)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	4	In PDB GlyTouCan (G22768VO)
5	AA, AB, BA, BB, CA... (A, I, B, J, C...)	SULFATE ION	non-polymer		96.1	48	Chemie (SO4)
6	MB, NB, OB, PB, QB... (H, L, A, B, C...)	water	water		18.0	59	Chemie (HOH)

Sequence modifications

G, I, J, K: 328 - 547 (UniProt: P01854)

PDB	External Database	Details
Ala 325	-	expression tag
Asp 326	-	expression tag
Pro 327	-	expression tag
Ala 328	Cys 209	engineered mutation
Cys 335	Gly 216	engineered mutation
Ala 548	-	expression tag
Ala 549	-	expression tag
Asp 550	-	expression tag
Asp 551	-	expression tag
Asp 552	-	expression tag
Asp 553	-	expression tag
Lys 554	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	292853.9
Branched	Number of molecules	4
	Total formula weight	3643.3
Non-Polymers*	Number of molecules	48
	Total formula weight	4611.0
All*	Total formula weight	301108.3

*Water molecules are not included.