5HI6
The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 163 | 18678.9 | 2 | UniProt (A0A0B6NYF5) Pfam (PF00186) UniProt (by SIFTS) (A0A3N4BLI0) | Yersinia pestis CO92 | |
| 2 | C, F (A, B) | METHOTREXATE | non-polymer | 454.4 | 2 | Chemie (MTX) | |||
| 3 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | E, G (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | H, I (B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 160 (UniProt: A0A0B6NYF5)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37357.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1098.1 | |
| All* | Total formula weight | 38455.9 |
