5HBT
Complex structure of Fab35 and human nAChR alpha1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Acetylcholine receptor subunit alpha 1 | polymer | 212 | 24626.9 | 1 | UniProt (G5E9G9) Pfam (PF02931) UniProt (by SIFTS) (P02708) | Homo sapiens (Human) | Cholinergic receptor,nicotinic,alpha 1 (Muscle),isoform CRA_c |
| 2 | B (C) | Fab35, Light Chain | polymer | 213 | 23393.0 | 1 | Rattus norvegicus (Norway rat) | ||
| 3 | C (D) | Fab35, Heavy Chain | polymer | 219 | 23879.8 | 1 | Rattus norvegicus (Norway rat) | ||
| 4 | D (A) | Alpha-bungarotoxin isoform V31 | polymer | 74 | 8033.3 | 1 | UniProt (P60616) Pfam (PF21947) | Bungarus multicinctus (Many-banded krait) | BGTX V31,Long neurotoxin 1 |
| 5 | E (E) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G68668TB) | |||
| 6 | F, G, H, I (B, C, D, A) | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
B: 1 - 211 (UniProt: G5E9G9)
| PDB | External Database | Details |
|---|---|---|
| Lys 0 | - | expression tag |
| Glu 8 | Val 28 | engineered mutation |
| Arg 149 | Trp 169 | engineered mutation |
| Ala 155 | Val 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 79933.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1559.4 | |
| All* | Total formula weight | 81492.4 |
