5H3E

Crystal structure of mouse isocitrate dehydrogenases 2 K256Q mutant complexed with isocitrate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isocitrate dehydrogenase [NADP], mitochondrial	polymer	422	47890.5	2	UniProt (P54071) Pfam (PF00180)	Mus musculus (Mouse)	Isocitrate dehydrogenase 2
2	C, E (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, F (A, B)	ISOCITRIC ACID	non-polymer		192.1	2	Chemie (ICT)
4	G, H (A, B)	water	water		18.0	128	Chemie (HOH)

Sequence modifications

A, B: 40 - 452 (UniProt: P54071)

PDB	External Database	Details
Met 39	-	expression tag
Gln 256	Lys 256	engineered mutation
Leu 453	-	expression tag
Glu 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95781.0
Non-Polymers*	Number of molecules	4
	Total formula weight	432.9
All*	Total formula weight	96213.8

*Water molecules are not included.