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5H3E

Crystal structure of mouse isocitrate dehydrogenases 2 K256Q mutant complexed with isocitrate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0006097biological_processglyoxylate cycle
A0006099biological_processtricarboxylic acid cycle
A0006102biological_processisocitrate metabolic process
A0006103biological_process2-oxoglutarate metabolic process
A0006739biological_processNADP+ metabolic process
A0006741biological_processNADP+ biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0046872molecular_functionmetal ion binding
A0051287molecular_functionNAD binding
A0060253biological_processnegative regulation of glial cell proliferation
A1903976biological_processnegative regulation of glial cell migration
A1904465biological_processnegative regulation of matrix metallopeptidase secretion
B0000287molecular_functionmagnesium ion binding
B0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005777cellular_componentperoxisome
B0005829cellular_componentcytosol
B0006097biological_processglyoxylate cycle
B0006099biological_processtricarboxylic acid cycle
B0006102biological_processisocitrate metabolic process
B0006103biological_process2-oxoglutarate metabolic process
B0006739biological_processNADP+ metabolic process
B0006741biological_processNADP+ biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0046872molecular_functionmetal ion binding
B0051287molecular_functionNAD binding
B0060253biological_processnegative regulation of glial cell proliferation
B1903976biological_processnegative regulation of glial cell migration
B1904465biological_processnegative regulation of matrix metallopeptidase secretion
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue MG A 501
ChainResidue
AASP314
AASP318
AICT502
BASP291

site_idAC2
Number of Residues13
Detailsbinding site for residue ICT A 502
ChainResidue
AARG172
ATYR179
AASP314
AMG501
AHOH644
BLYS251
BILE254
BASP291
ATHR117
ASER134
AASN136
AARG140
AARG149

site_idAC3
Number of Residues4
Detailsbinding site for residue MG B 501
ChainResidue
AASP291
BASP314
BASP318
BICT502

site_idAC4
Number of Residues13
Detailsbinding site for residue ICT B 502
ChainResidue
ALYS251
AILE254
AASP291
BTHR117
BSER134
BASN136
BARG140
BARG149
BARG172
BTYR179
BASP314
BALA347
BMG501

Functional Information from PROSITE/UniProt
site_idPS00470
Number of Residues20
DetailsIDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVqSDilAqgf.GSLGL
ChainResidueDetails
AASN310-LEU329

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"O75874","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P33198","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsSite: {"description":"Critical for catalysis","evidences":[{"source":"UniProtKB","id":"P33198","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues18
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P48735","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues16
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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