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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5GAN

The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(V)		U4 snRNApolymer16051186.01GenBank (807071957)Saccharomyces cerevisiae (Baker's yeast)U4 snRNA
2B
(W)		U6 snRNApolymer11235883.21GenBank (807071964)Saccharomyces cerevisiae (Baker's yeast)U6 snRNA
3C
(A)		Pre-mRNA-splicing factor 8polymer2413279867.51UniProt (P33334)
Pfam (PF10598)
Pfam (PF10597)
Pfam (PF10596)
Pfam (PF12134)
Pfam (PF08084)
Pfam (PF08082)
Pfam (PF08083)		Saccharomyces cerevisiae (Baker's yeast)Prp8
4D
(H)		U4/U6 small nuclear ribonucleoprotein PRP4polymer46552507.01UniProt (P20053)
Pfam (PF00400)		Saccharomyces cerevisiae (Baker's yeast)Pre-mRNA-processing protein 4, Prp4
5E
(J)		Pre-mRNA-splicing factor 6polymer899104370.11UniProt (P19735)
Pfam (PF06424)		Saccharomyces cerevisiae (Baker's yeast)Prp6
6F
(D)		Spliceosomal protein DIB1polymer14316798.41UniProt (Q06819)
Pfam (PF02966)		Saccharomyces cerevisiae (Baker's yeast)
7G
(F)		Pre-mRNA-processing factor 31polymer49456382.51UniProt (P49704)
Pfam (PF01798)
Pfam (PF09785)		Saccharomyces cerevisiae (Baker's yeast)Prp31
8H
(G)		U4/U6 small nuclear ribonucleoprotein PRP3polymer46955974.31UniProt (Q03338)
Pfam (PF08572)
Pfam (PF06544)		Saccharomyces cerevisiae (Baker's yeast)Pre-mRNA-splicing factor 3, Prp3
9I
(B)		Pre-mRNA-splicing helicase BRR2polymer2163246470.31UniProt (P32639)
Pfam (PF21188)
Pfam (PF18149)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF23445)
Pfam (PF02889)		Saccharomyces cerevisiae (Baker's yeast)Protein Snu246, Brr2
10J
(x)		Unknown proteinpolymer1008528.51Saccharomyces cerevisiae (Baker's yeast)
11K, S
(k, b)		Small nuclear ribonucleoprotein-associated protein Bpolymer19622427.02UniProt (P40018)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)snRNP-B,Sm protein B,SmB
12L, X
(l, h)		Small nuclear ribonucleoprotein Sm D1polymer14616296.82UniProt (Q02260)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)Sm-D1,snRNP core protein D1, U4 SmD1
13M, Y
(m, j)		Small nuclear ribonucleoprotein Sm D2polymer11012876.12UniProt (Q06217)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)Sm-D2,snRNP core protein D2, SmD2
14N, W
(n, d)		Small nuclear ribonucleoprotein Sm D3polymer10111240.12UniProt (P43321)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)Sm-D3,snRNP core protein D3, SmD3
15O, T
(p, e)		Small nuclear ribonucleoprotein Epolymer9410385.12UniProt (Q12330)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)snRNP-E,Sm protein E,SmE
16P, U
(q, f)		Small nuclear ribonucleoprotein Fpolymer869669.92UniProt (P54999)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)snRNP-F,Sm protein F,SmF
17Q, V
(r, g)		Small nuclear ribonucleoprotein Gpolymer778490.82UniProt (P40204)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)snRNP-G,Sm protein G,SmG
18R
(E)		Snu66polymer32828660.01UniProt (by SIFTS) (Q12420)Saccharomyces cerevisiae (Baker's yeast)
19Z
(U)		U5 snRNApolymer21468643.31GenBank (807071959)Saccharomyces cerevisiae (Baker's yeast)
20AA
(K)		13 kDa ribonucleoprotein-associated proteinpolymer12613582.91UniProt (P39990)
Pfam (PF01248)		Saccharomyces cerevisiae (Baker's yeast)Small nuclear ribonucleoprotein-associated protein 1, Snu13
21BA
(2)		U6 snRNA-associated Sm-like protein LSm2polymer9511177.91UniProt (P38203)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)Small nuclear ribonucleoprotein D homolog SNP3
22CA
(3)		U6 snRNA-associated Sm-like protein LSm3polymer8910039.31UniProt (P57743)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)SmX4 protein
23DA
(4)		U6 snRNA-associated Sm-like protein LSm4polymer18721298.11UniProt (P40070)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)LSm4
24EA
(5)		U6 snRNA-associated Sm-like protein LSm5polymer9310433.01UniProt (P40089)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)LSm5
25FA
(6)		U6 snRNA-associated Sm-like protein LSm6polymer869406.61UniProt (A6ZYX7)
Pfam (PF01423)
UniProt (by SIFTS) (Q06406)		Saccharomyces cerevisiae (Baker's yeast)LSm6
26GA
(7)		U6 snRNA-associated Sm-like protein LSm7polymer11513027.01UniProt (P53905)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)LSm7
27HA
(8)		U6 snRNA-associated Sm-like protein LSm8polymer10912403.41UniProt (P47093)
Pfam (PF01423)		Saccharomyces cerevisiae (Baker's yeast)LSm8
28IA
(C)		Pre-mRNA-splicing factor SNU114polymer1008114132.11UniProt (P36048)
Pfam (PF16004)
Pfam (PF00009)
Pfam (PF03764)
Pfam (PF00679)		Saccharomyces cerevisiae (Baker's yeast)114 kDa U5 small nuclear ribonucleoprotein component,Growth inhibitory protein 10, Snu114
29JA
(C)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
PubChem (177679032)
PubChem (135400627)
PubChem (135487750)
PubChem (136088935)
PubChem (136803486)
PubChem (135398633)
PubChem (135544356)
PubChem (135547949)
PubChem (135600366)
PubChem (135749822)
PubChem (136005188)
PubChem (136073923)
PubChem (136240914)
PubChem (136664747)
PubChem (136772743)
PubChem (136772744)
PubChem (136803487)
PubChem (137286749)
PubChem (164715984)
PubChem (171699466)
Sequence modifications
C: 1 - 1008 (UniProt: P36048)
PDBExternal DatabaseDetails
Ser 530Glu 530conflict
Lys 531Asp 531conflict
Thr 532Asp 532conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains35
Total formula weight1403542.9
Non-Polymers*Number of molecules1
Total formula weight523.2
All*Total formula weight1404066.1
*Water molecules are not included.

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PDB entries from 2026-05-06

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