5FUR
Structure of human TFIID-IIA bound to core promoter DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | TATA-BOX-BINDING PROTEIN | polymer | 339 | 37729.9 | 1 | UniProt (P20226) Pfam (PF00352) In PDB | HOMO SAPIENS (HUMAN) | TATA SEQUENCE-BINDING PROTEIN, TATA-BINDING FACTOR, TATA-BOX FACTOR, TRANSCRIPTION INITIATION FACTOR TFIID TBP SUBUNIT |
| 2 | B | TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 | polymer | 43 | 5098.9 | 1 | UniProt (P52655) In PDB | HOMO SAPIENS (HUMAN) | GENERAL TRANSCRIPTION FACTOR IIA SUBUNIT 1, TFIIAL, TRANSCRIPTION INITIATION FACTOR TFIIA 42 KDA SUBUNIT, TFIIA-42 |
| 3 | C | TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 | polymer | 47 | 5594.3 | 1 | UniProt (P52655) Pfam (PF03153) In PDB | HOMO SAPIENS (HUMAN) | GENERAL TRANSCRIPTION FACTOR IIA SUBUNIT 1, TFIIAL, TRANSCRIPTION INITIATION FACTOR TFIIA 42 KDA SUBUNIT, TFIIA-42 |
| 4 | D | TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 | polymer | 97 | 11275.8 | 1 | UniProt (P52657) Pfam (PF02268) Pfam (PF02751) In PDB | HOMO SAPIENS (HUMAN) | GENERAL TRANSCRIPTION FACTOR IIA SUBUNIT 2, TFIIA P12 SUBUNIT, TFIIAS, TRANSCRIPTION INITIATION FACTOR IIA GAMMA CHAIN, TFIIA- GAMMA |
| 5 | E | SUPER CORE PROMOTER | polymer | 89 | 27664.6 | 1 | HOMO SAPIENS (HUMAN) | ||
| 6 | F | SUPER CORE PROMOTER | polymer | 93 | 28485.1 | 1 | HOMO SAPIENS (HUMAN) | ||
| 7 | G | TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 | polymer | 1893 | 215152.4 | 1 | UniProt (P21675) Pfam (PF00439) Pfam (PF09247) Pfam (PF12157) Pfam (PF15288) In PDB | HOMO SAPIENS (HUMAN) | CELL CYCLE GENE 1 PROTEIN, TBP-ASSOCIATED FACTOR 250 KDA, P250, TRANSCRIPTION INITIATION FACTOR TFIID 250 KDA SUBUNIT, TAFII250 |
| 8 | H | TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 | polymer | 349 | 40325.1 | 1 | UniProt (Q15545) Pfam (PF04658) In PDB | HOMO SAPIENS (HUMAN) | RNA POLYMERASE II TBP-ASSOCIATED FACTOR SUBUNIT F, TRANSCRIPTION INITIATION FACTOR TFIID 55 KDA SUBUNIT, TAFII55 |
| 9 | I | TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 | polymer | 1199 | 137160.0 | 1 | UniProt (Q6P1X5) In PDB | HOMO SAPIENS (HUMAN) | 150 KDA COFACTOR OF INITIATOR FUNCTION, RNA POLYMERASE II TBP-ASSOCIATED FACTOR SUBUNIT B, TBP-ASSOCIATED FACTOR 150 KDA, TRANSCRIPTION INITIATION FACTOR TFIID 150 KDA SUBUNIT, TAFII150 |
| 10 | J, K | TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 | polymer | 677 | 72749.3 | 2 | UniProt (P49848) Pfam (PF02969) Pfam (PF07571) In PDB | HOMO SAPIENS (HUMAN) | RNA POLYMERASE II TBP-ASSOCIATED FACTOR SUBUNIT E, TRANSCRIPTION INITIATION FACTOR TFIID 70 KDA SUBUNIT, TAFII70, TRANSCRIPTION INITIATION FACTOR TFIID 80 KDA SUBUNIT, TAFII80 |
| 11 | L | TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 | polymer | 310 | 34304.4 | 1 | UniProt (Q7Z7C8) Pfam (PF07524) Pfam (PF10406) In PDB | HOMO SAPIENS (HUMAN) | PROTEIN TAUBE NUSS, TBP-ASSOCIATED FACTOR 43 KDA, TBP-ASSOCIATED FACTOR 8, TRANSCRIPTION INITIATION FACTOR TFIID 43 KDA SUBUNIT, HTAFII43 |
Sequence modifications
G: 1 - 1893 (UniProt: P21675)
| PDB | External Database | Details |
|---|---|---|
| Val 178 | - | insertion |
| Ser 179 | - | insertion |
| Glu 180 | - | insertion |
| Asn 181 | - | insertion |
| Gly 182 | - | insertion |
| Glu 183 | - | insertion |
| Gly 184 | - | insertion |
| Ile 185 | - | insertion |
| Ile 186 | - | insertion |
| Leu 187 | - | insertion |
| Pro 188 | - | insertion |
| Ser 189 | - | insertion |
| Ile 190 | - | insertion |
| Ile 191 | - | insertion |
| Ala 192 | - | insertion |
| Pro 193 | - | insertion |
| Ser 194 | - | insertion |
| Ser 195 | - | insertion |
| Leu 196 | - | insertion |
| Ala 197 | - | insertion |
| Ser 198 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 688289.2 | |
| All* | Total formula weight | 688289.2 |
