Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FUR

Structure of human TFIID-IIA bound to core promoter DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0000791	cellular_component	euchromatin
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
A	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
A	0001046	molecular_function	core promoter sequence-specific DNA binding
A	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
A	0001093	molecular_function	TFIIB-class transcription factor binding
A	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
A	0001188	biological_process	RNA polymerase I preinitiation complex assembly
A	0001673	cellular_component	male germ cell nucleus
A	0001674	cellular_component	female germ cell nucleus
A	0001939	cellular_component	female pronucleus
A	0001940	cellular_component	male pronucleus
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
A	0005669	cellular_component	transcription factor TFIID complex
A	0005672	cellular_component	transcription factor TFIIA complex
A	0005737	cellular_component	cytoplasm
A	0006352	biological_process	DNA-templated transcription initiation
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006383	biological_process	transcription by RNA polymerase III
A	0007283	biological_process	spermatogenesis
A	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
A	0017162	molecular_function	aryl hydrocarbon receptor binding
A	0019899	molecular_function	enzyme binding
A	0032991	cellular_component	protein-containing complex
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0045120	cellular_component	pronucleus
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0140297	molecular_function	DNA-binding transcription factor binding
B	0005672	cellular_component	transcription factor TFIIA complex
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0005672	cellular_component	transcription factor TFIIA complex
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0005672	cellular_component	transcription factor TFIIA complex
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000209	biological_process	protein polyubiquitination
G	0000785	cellular_component	chromatin
G	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
G	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
G	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
G	0002039	molecular_function	p53 binding
G	0003677	molecular_function	DNA binding
G	0004402	molecular_function	histone acetyltransferase activity
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005667	cellular_component	transcription regulator complex
G	0005669	cellular_component	transcription factor TFIID complex
G	0005730	cellular_component	nucleolus
G	0006325	biological_process	chromatin organization
G	0006338	biological_process	chromatin remodeling
G	0006352	biological_process	DNA-templated transcription initiation
G	0006361	biological_process	transcription initiation at RNA polymerase I promoter
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006468	biological_process	protein phosphorylation
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006974	biological_process	DNA damage response
G	0010629	biological_process	negative regulation of gene expression
G	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
G	0016301	molecular_function	kinase activity
G	0016310	biological_process	phosphorylation
G	0016746	molecular_function	acyltransferase activity
G	0016922	molecular_function	nuclear receptor binding
G	0017025	molecular_function	TBP-class protein binding
G	0018105	biological_process	peptidyl-serine phosphorylation
G	0018107	biological_process	peptidyl-threonine phosphorylation
G	0030901	biological_process	midbrain development
G	0032092	biological_process	positive regulation of protein binding
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0034644	biological_process	cellular response to UV
G	0042789	biological_process	mRNA transcription by RNA polymerase II
G	0043565	molecular_function	sequence-specific DNA binding
G	0044024	molecular_function	histone H2AS1 kinase activity
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046777	biological_process	protein autophosphorylation
G	0046982	molecular_function	protein heterodimerization activity
G	0050821	biological_process	protein stabilization
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0061628	molecular_function	H3K27me3 modified histone binding
G	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
G	0061631	molecular_function	ubiquitin conjugating enzyme activity
G	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
G	0070577	molecular_function	lysine-acetylated histone binding
G	0071318	biological_process	cellular response to ATP
G	0071339	cellular_component	MLL1 complex
G	0106310	molecular_function	protein serine kinase activity
G	0140416	molecular_function	transcription regulator inhibitor activity
G	0140566	molecular_function	histone reader activity
G	1901796	biological_process	regulation of signal transduction by p53 class mediator
G	1902806	biological_process	regulation of cell cycle G1/S phase transition
G	1905502	molecular_function	acetyl-CoA binding
G	1905524	biological_process	negative regulation of protein autoubiquitination
G	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
G	2000825	biological_process	positive regulation of androgen receptor activity
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000296	biological_process	spermine transport
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0001097	molecular_function	TFIIH-class transcription factor complex binding
H	0001673	cellular_component	male germ cell nucleus
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005667	cellular_component	transcription regulator complex
H	0005669	cellular_component	transcription factor TFIID complex
H	0005737	cellular_component	cytoplasm
H	0006282	biological_process	regulation of DNA repair
H	0006352	biological_process	DNA-templated transcription initiation
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006469	biological_process	negative regulation of protein kinase activity
H	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
H	0030520	biological_process	estrogen receptor signaling pathway
H	0033276	cellular_component	transcription factor TFTC complex
H	0035035	molecular_function	histone acetyltransferase binding
H	0042789	biological_process	mRNA transcription by RNA polymerase II
H	0042809	molecular_function	nuclear vitamin D receptor binding
H	0045344	biological_process	negative regulation of MHC class I biosynthetic process
H	0045347	biological_process	negative regulation of MHC class II biosynthetic process
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046966	molecular_function	nuclear thyroid hormone receptor binding
H	0046982	molecular_function	protein heterodimerization activity
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0061628	molecular_function	H3K27me3 modified histone binding
H	0071339	cellular_component	MLL1 complex
H	0106140	molecular_function	P-TEFb complex binding
H	0140297	molecular_function	DNA-binding transcription factor binding
I	0000086	biological_process	G2/M transition of mitotic cell cycle
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0003682	molecular_function	chromatin binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005669	cellular_component	transcription factor TFIID complex
I	0006282	biological_process	regulation of DNA repair
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0014070	biological_process	response to organic cyclic compound
I	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
I	0033276	cellular_component	transcription factor TFTC complex
I	0042789	biological_process	mRNA transcription by RNA polymerase II
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0000124	cellular_component	SAGA complex
J	0003677	molecular_function	DNA binding
J	0003713	molecular_function	transcription coactivator activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005669	cellular_component	transcription factor TFIID complex
J	0005829	cellular_component	cytosol
J	0006282	biological_process	regulation of DNA repair
J	0006352	biological_process	DNA-templated transcription initiation
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006915	biological_process	apoptotic process
J	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
J	0017162	molecular_function	aryl hydrocarbon receptor binding
J	0032991	cellular_component	protein-containing complex
J	0033276	cellular_component	transcription factor TFTC complex
J	0042789	biological_process	mRNA transcription by RNA polymerase II
J	0045786	biological_process	negative regulation of cell cycle
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0046695	cellular_component	SLIK (SAGA-like) complex
J	0046982	molecular_function	protein heterodimerization activity
J	0051123	biological_process	RNA polymerase II preinitiation complex assembly
J	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0071339	cellular_component	MLL1 complex
K	0000124	cellular_component	SAGA complex
K	0003677	molecular_function	DNA binding
K	0003713	molecular_function	transcription coactivator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005669	cellular_component	transcription factor TFIID complex
K	0005829	cellular_component	cytosol
K	0006282	biological_process	regulation of DNA repair
K	0006352	biological_process	DNA-templated transcription initiation
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006366	biological_process	transcription by RNA polymerase II
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0006915	biological_process	apoptotic process
K	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
K	0017162	molecular_function	aryl hydrocarbon receptor binding
K	0032991	cellular_component	protein-containing complex
K	0033276	cellular_component	transcription factor TFTC complex
K	0042789	biological_process	mRNA transcription by RNA polymerase II
K	0045786	biological_process	negative regulation of cell cycle
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0046695	cellular_component	SLIK (SAGA-like) complex
K	0046982	molecular_function	protein heterodimerization activity
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
K	0071339	cellular_component	MLL1 complex
L	0001112	biological_process	DNA-templated transcription open complex formation
L	0001833	biological_process	inner cell mass cell proliferation
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005669	cellular_component	transcription factor TFIID complex
L	0005737	cellular_component	cytoplasm
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
L	0030154	biological_process	cell differentiation
L	0042789	biological_process	mRNA transcription by RNA polymerase II
L	0045598	biological_process	regulation of fat cell differentiation
L	0046982	molecular_function	protein heterodimerization activity
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0051123	biological_process	RNA polymerase II preinitiation complex assembly
L	0051457	biological_process	maintenance of protein location in nucleus
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
A	TYR192-VAL241
A	TYR283-LEU332

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. TypFhtpvNakvvk..DYYkiItrpMdlqtLrenvrkrl..Ypsreefrehlel.IvkNSatY

Chain	Residue	Details
G	THR1423-TYR1480
G	SER1546-TYR1603

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
L	ALA2
K	THR120
A	LYS218
A	ASN257
A	ARG294

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
L	THR130
K	THR248
I	SER1198

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
L	SER271
K	TYR253

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q63801

Chain	Residue	Details
J	SER264
K	SER264

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744\|PubMed:24129315

Chain	Residue	Details
J	ARG524
K	ARG524
G	SER1799
G	SER1802
G	SER1820

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q62311

Chain	Residue	Details
J	SER626
K	SER626

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
J	SER634
J	SER636
K	SER634
K	SER636

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:16964243, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
J	SER653
K	SER653

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:16964243, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
J	THR660
K	THR660

site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
J	LYS196
K	LYS196

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)