5FTH

Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (zinc form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	GLUTAMATE RECEPTOR 2	polymer	291	32264.1	3	UniProt (P19491) Pfam (PF10613) Pfam (PF00060)	RATTUS NORVEGICUS (NORWAY RAT)	GLUR-2, AMPA-SELECTIVE GLUTAMATE RECEPTOR 2, GLUR-B, GLUR-K2, GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2, GLUA2
2	D, G, J (A, B, C)	GLUTAMIC ACID	non-polymer		147.1	3	Chemie (GLU)
3	E, F, H, I, K (A, B, C)	ZINC ION	non-polymer		65.4	5	Chemie (ZN)

Sequence modifications

A, B, C: 383 - 506 (UniProt: P19491)

PDB	External Database	Details
Met 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag
His 370	-	expression tag
Ser 371	-	expression tag
Ser 372	-	expression tag
Gly 373	-	expression tag
Leu 374	-	expression tag
Val 375	-	expression tag
Pro 376	-	expression tag
Arg 377	-	expression tag
Gly 378	-	expression tag
Ser 379	-	expression tag
Ala 380	-	expression tag
Met 381	-	expression tag
Gly 382	-	expression tag
Arg 389	Gly 410	engineered mutation
Gly 390	Leu 411	engineered mutation
Ala 391	Glu 412	engineered mutation

A, B, C: 632 - 775 (UniProt: P19491)

PDB	External Database	Details
Gly 555	-	linker
Thr 566	-	linker
Met 738	Lys 759	engineered mutation
Lys 744	Thr 765	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	96792.3
Non-Polymers*	Number of molecules	8
	Total formula weight	768.4
All*	Total formula weight	97560.7

*Water molecules are not included.