5FQL
Insights into Hunter syndrome from the structure of iduronate-2- sulfatase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | IDURONATE-2-SULFATASE | polymer | 525 | 59435.5 | 1 | UniProt (P22304) Pfam (PF00884) In PDB | HOMO SAPIENS (HUMAN) | 3.1.6.13, ALPHA-L-IDURONATE SULFATE SULFATASE, IDURSULFASE, IDURONATE 2-SULFATASE 42 KDA CHAIN, IDURONATE 2-SULFATASE 14 KDA CHAIN |
| 2 | B, C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 3 | D, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 7 | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A: 26 - 550 (UniProt: P22304)
| PDB | External Database | Details |
|---|---|---|
| Als 84 | Cys 84 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 59435.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2560.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 588.9 | |
| All* | Total formula weight | 62584.8 |
