5FQL
Insights into Hunter syndrome from the structure of iduronate-2- sulfatase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004423 | molecular_function | iduronate-2-sulfatase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0006027 | biological_process | glycosaminoglycan catabolic process |
| A | 0008484 | molecular_function | sulfuric ester hydrolase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030200 | biological_process | heparan sulfate proteoglycan catabolic process |
| A | 0030209 | biological_process | dermatan sulfate catabolic process |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00149 |
| Number of Residues | 12 |
| Details | SULFATASE_2 Sulfatases signature 2. GYvTmsVGKvFH |
| Chain | Residue | Details |
| A | GLY127-HIS138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|Ref.13 |
| Chain | Residue | Details |
| A | ALS84 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P15289 |
| Chain | Residue | Details |
| A | HIS138 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|Ref.13, ECO:0007744|PDB:5FQL |
| Chain | Residue | Details |
| A | ASP45 | |
| A | ASP334 | |
| A | HIS335 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:1303211, ECO:0007744|PDB:5FQL |
| Chain | Residue | Details |
| A | ASP46 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: via 3-oxoalanine => ECO:0000269|Ref.13, ECO:0007744|PDB:5FQL |
| Chain | Residue | Details |
| A | ALS84 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: 3-oxoalanine (Cys) => ECO:0000269|Ref.13 |
| Chain | Residue | Details |
| A | ALS84 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|Ref.13, ECO:0007744|PDB:5FQL |
| Chain | Residue | Details |
| A | ASN115 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.13, ECO:0007744|PDB:5FQL |
| Chain | Residue | Details |
| A | ASN144 | |
| A | ASN246 | |
| A | ASN280 | |
| A | ASN325 | |
| A | ASN513 | |
| A | ASN537 |
