5FQL
Insights into Hunter syndrome from the structure of iduronate-2- sulfatase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004423 | molecular_function | iduronate-2-sulfatase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0006027 | biological_process | glycosaminoglycan catabolic process |
| A | 0008484 | molecular_function | sulfuric ester hydrolase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030200 | biological_process | heparan sulfate proteoglycan catabolic process |
| A | 0030209 | biological_process | dermatan sulfate proteoglycan catabolic process |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1901136 | biological_process | carbohydrate derivative catabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00149 |
| Number of Residues | 12 |
| Details | SULFATASE_2 Sulfatases signature 2. GYvTmsVGKvFH |
| Chain | Residue | Details |
| A | GLY127-HIS138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2018","submissionDatabase":"PDB data bank","title":"Structural insights of idursulfase beta.","authors":["Kim H.","Kim D.","Hong J.","Lee K.","Seo J.","Oh B.H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P15289","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2018","submissionDatabase":"PDB data bank","title":"Structural insights of idursulfase beta.","authors":["Kim H.","Kim D.","Hong J.","Lee K.","Seo J.","Oh B.H."]}},{"source":"PDB","id":"5FQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"1303211","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"via 3-oxoalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2018","submissionDatabase":"PDB data bank","title":"Structural insights of idursulfase beta.","authors":["Kim H.","Kim D.","Hong J.","Lee K.","Seo J.","Oh B.H."]}},{"source":"PDB","id":"5FQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"3-oxoalanine (Cys)","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2018","submissionDatabase":"PDB data bank","title":"Structural insights of idursulfase beta.","authors":["Kim H.","Kim D.","Hong J.","Lee K.","Seo J.","Oh B.H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2018","submissionDatabase":"PDB data bank","title":"Structural insights of idursulfase beta.","authors":["Kim H.","Kim D.","Hong J.","Lee K.","Seo J.","Oh B.H."]}},{"source":"PDB","id":"5FQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2018","submissionDatabase":"PDB data bank","title":"Structural insights of idursulfase beta.","authors":["Kim H.","Kim D.","Hong J.","Lee K.","Seo J.","Oh B.H."]}},{"source":"PDB","id":"5FQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
