5FQD
Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | DNA DAMAGE-BINDING PROTEIN 1 | polymer | 856 | 95773.7 | 2 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB | HOMO SAPIENS (HUMAN) | DDB P127 SUBUNIT, DNA DAMAGE-BINDING PROTEIN A, DDBA, DAMAGE -SPECIFIC DNA-BINDING PROTEIN 1, HBV X-ASSOCIATED PROTEIN 1, XAP-1, UV-DAMAGED DNA-BINDING FACTOR, UV-DAMAGED DNA-BINDING PROTEIN 1, UV-DDB 1, XPE-BINDING FACTOR, XPE-BF, XERODERMA PIGMENTOSUM GROUP E-COMPLEMENTING PROTEIN, XPCE |
2 | B, E | PROTEIN CEREBLON | polymer | 426 | 48976.1 | 2 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB | HOMO SAPIENS (HUMAN) | |
3 | C, F | CASEIN KINASE I ISOFORM ALPHA | polymer | 341 | 39302.2 | 2 | UniProt (P48729) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | CKI-ALPHA, CK1, CASEINE KINASE 1A |
4 | B, E | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | B, E | S-Lenalidomide | non-polymer | 259.3 | 2 | Chemie (LVY) | |||
6 | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 395 (UniProt: Q16531)
A, D: 709 - 1140 (UniProt: Q16531)
B, E: 41 - 442 (UniProt: Q96SW2)
C, F: 1 - 337 (UniProt: P48729)
PDB | External Database | Details |
---|---|---|
Met -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
Val -12 | - | expression tag |
Asp -11 | - | expression tag |
Glu -10 | - | expression tag |
Glu -9 | - | expression tag |
Asn -8 | - | expression tag |
Leu -7 | - | expression tag |
Tyr -6 | - | expression tag |
Phe -5 | - | expression tag |
Gln -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 396 | - | linker |
Asn 397 | - | linker |
Gly 398 | - | linker |
Asn 399 | - | linker |
Ser 400 | - | linker |
Gly 401 | - | linker |
PDB | External Database | Details |
---|---|---|
Met 17 | - | expression tag |
Asp 18 | - | expression tag |
Trp 19 | - | expression tag |
Ser 20 | - | expression tag |
His 21 | - | expression tag |
Pro 22 | - | expression tag |
Gln 23 | - | expression tag |
Phe 24 | - | expression tag |
Glu 25 | - | expression tag |
Lys 26 | - | expression tag |
Ser 27 | - | expression tag |
Ala 28 | - | expression tag |
Val 29 | - | expression tag |
Asp 30 | - | expression tag |
Glu 31 | - | expression tag |
Asn 32 | - | expression tag |
Leu 33 | - | expression tag |
Tyr 34 | - | expression tag |
Phe 35 | - | expression tag |
Gln 36 | - | expression tag |
Gly 37 | - | expression tag |
Gly 38 | - | expression tag |
Gly 39 | - | expression tag |
Arg 40 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 368104.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 649.3 | |
All* | Total formula weight | 368753.4 |