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5FQD

Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0005634cellular_componentnucleus
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0016020cellular_componentmembrane
B0016567biological_processprotein ubiquitination
B0030177biological_processpositive regulation of Wnt signaling pathway
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0034766biological_processnegative regulation of monoatomic ion transmembrane transport
B0035641biological_processlocomotory exploration behavior
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
C0000775cellular_componentchromosome, centromeric region
C0000776cellular_componentkinetochore
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005847cellular_componentmRNA cleavage and polyadenylation specificity factor complex
C0005856cellular_componentcytoskeleton
C0005929cellular_componentcilium
C0006468biological_processprotein phosphorylation
C0007030biological_processGolgi organization
C0007165biological_processsignal transduction
C0007166biological_processcell surface receptor signaling pathway
C0016020cellular_componentmembrane
C0016055biological_processWnt signaling pathway
C0016607cellular_componentnuclear speck
C0018105biological_processpeptidyl-serine phosphorylation
C0019082biological_processviral protein processing
C0030877cellular_componentbeta-catenin destruction complex
C0031670biological_processcellular response to nutrient
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0035025biological_processpositive regulation of Rho protein signal transduction
C0036064cellular_componentciliary basal body
C0042995cellular_componentcell projection
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043229cellular_componentintracellular organelle
C0045095cellular_componentkeratin filament
C0045104biological_processintermediate filament cytoskeleton organization
C0051301biological_processcell division
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0106310molecular_functionprotein serine kinase activity
C1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
C1904263biological_processpositive regulation of TORC1 signaling
D0003676molecular_functionnucleic acid binding
D0005634cellular_componentnucleus
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0016020cellular_componentmembrane
E0016567biological_processprotein ubiquitination
E0030177biological_processpositive regulation of Wnt signaling pathway
E0031333biological_processnegative regulation of protein-containing complex assembly
E0031334biological_processpositive regulation of protein-containing complex assembly
E0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
E0034766biological_processnegative regulation of monoatomic ion transmembrane transport
E0035641biological_processlocomotory exploration behavior
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0044325molecular_functiontransmembrane transporter binding
E0046872molecular_functionmetal ion binding
E0048471cellular_componentperinuclear region of cytoplasm
F0000775cellular_componentchromosome, centromeric region
F0000776cellular_componentkinetochore
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005847cellular_componentmRNA cleavage and polyadenylation specificity factor complex
F0005856cellular_componentcytoskeleton
F0005929cellular_componentcilium
F0006468biological_processprotein phosphorylation
F0007030biological_processGolgi organization
F0007165biological_processsignal transduction
F0007166biological_processcell surface receptor signaling pathway
F0016020cellular_componentmembrane
F0016055biological_processWnt signaling pathway
F0016607cellular_componentnuclear speck
F0018105biological_processpeptidyl-serine phosphorylation
F0019082biological_processviral protein processing
F0030877cellular_componentbeta-catenin destruction complex
F0031670biological_processcellular response to nutrient
F0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
F0035025biological_processpositive regulation of Rho protein signal transduction
F0036064cellular_componentciliary basal body
F0042995cellular_componentcell projection
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0043229cellular_componentintracellular organelle
F0045095cellular_componentkeratin filament
F0045104biological_processintermediate filament cytoskeleton organization
F0051301biological_processcell division
F0090090biological_processnegative regulation of canonical Wnt signaling pathway
F0106310molecular_functionprotein serine kinase activity
F1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
F1904263biological_processpositive regulation of TORC1 signaling
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1437
ChainResidue
BCYS323
BCYS326
BCYS391
BCYS394

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 1437
ChainResidue
ECYS323
ECYS326
ECYS391
ECYS394

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE LVY B 1438
ChainResidue
BPRO352
BHIS353
BGLU377
BHIS378
BSER379
BTRP380
BTRP386
BTRP400
BPHE402
CILE35
CASN39
CGLY40
BASN351

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE LVY E 1438
ChainResidue
EASN351
EPRO352
EHIS353
EGLU377
EHIS378
ESER379
ETRP380
ETRP386
ETRP400
EPHE402
FILE35
FILE37
FTHR38
FASN39
FGLY40

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlAinitngee..........VAVK
ChainResidueDetails
CILE23-LYS46

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDIKpdNFLM
ChainResidueDetails
CPHE132-MET144

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
ECYS326
EHIS378
ETRP380
ETRP386
ECYS391
ECYS394
CASP136
FASP136
BHIS378
BTRP380
BTRP386
BCYS391
BCYS394
ECYS323

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
FILE23
FLYS46
CILE23
CLYS46

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:22814378
ChainResidueDetails
CALA2
FALA2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DLYS1121
CSER4
FSER4

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS8
FLYS8

221051

PDB entries from 2024-06-12

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