5FLV
Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E, I, M | HOMEOBOX PROTEIN NKX-2.5, T-BOX TRANSCRIPTION FACTOR TBX5 | polymer | 285 | 32947.8 | 4 | UniProt (P42582) Pfam (PF00046) Pfam (PF00907) UniProt (by SIFTS) (P70326) In PDB | MUS MUSCULUS (HOUSE MOUSE) | CARDIAC-SPECIFIC HOMEOBOX, HOMEOBOX PROTEIN CSX, HOMEOBOX PROTEIN NK-2 HOMOLOG E, T-BOX PROTEIN 5 |
2 | B, F, J, N | 5'-D(*TP*CP*TP*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP *TP*GP*AP*AP*GP*TP*GP*G)-3' | polymer | 22 | 6693.3 | 4 | MUS MUSCULUS | ||
3 | C, G, K, O | 5'-D(*AP*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP *GP*TP*GP*AP*GP*AP*AP*G)-3' | polymer | 22 | 6809.4 | 4 | MUS MUSCULUS | ||
4 | A, C | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) |
Sequence modifications
A, E, I, M: 134 - 197 (UniProt: P42582)
A, E, I, M: 1051 - 1251 (UniProt: P42582)
PDB | External Database | Details |
---|---|---|
Gly 130 | - | expression tag |
Ala 131 | - | expression tag |
Met 132 | - | expression tag |
Gly 133 | - | expression tag |
Ser 192 | Cys 192 | engineered mutation |
Ser 198 | - | linker |
Ser 199 | - | linker |
Ser 200 | - | linker |
Ser 201 | - | linker |
Ser 202 | - | linker |
Ser 203 | - | linker |
Ser 204 | - | linker |
Ser 205 | - | linker |
Ser 206 | - | linker |
Ser 207 | - | linker |
Ser 208 | - | linker |
Ser 209 | - | linker |
Ser 210 | - | linker |
Ser 211 | - | linker |
Ser 212 | - | linker |
Ala 213 | - | linker |
PDB | External Database | Details |
---|---|---|
Ser 1202 | Cys 202 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 185802.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 388.5 | |
All* | Total formula weight | 186190.7 |