5FLV

Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
E	0045893	biological_process	positive regulation of DNA-templated transcription
I	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
I	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
I	0003677	molecular_function	DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0005634	cellular_component	nucleus
I	0006355	biological_process	regulation of DNA-templated transcription
I	0045893	biological_process	positive regulation of DNA-templated transcription
M	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
M	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
M	0003677	molecular_function	DNA binding
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0005634	cellular_component	nucleus
M	0006355	biological_process	regulation of DNA-templated transcription
M	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 A 2239

Chain	Residue
A	ILE1054
A	VAL1056
A	HIS1204
O	DT9

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 C 2025

Chain	Residue
C	DT9
M	PHE1057
M	LEU1058
M	HIS1059

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Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. LAsvLkLTstQVKIWFqNrryksK

Chain	Residue	Details
A	LEU170-LYS193

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site_id	PS01264
Number of Residues	19
Details	TBOX_2 T-box domain signature 2. VHPDSpatGahWMrqlVsF

Chain	Residue	Details
A	VAL1137-PHE1155

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site_id	PS01283
Number of Residues	20
Details	TBOX_1 T-box domain signature 1. LWlkFhevgTEMIITkaGRR

Chain	Residue	Details
A	LEU1063-ARG1082

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	236
Details	DNA_BIND: Homeobox => ECO:0000250|UniProtKB:P52952, ECO:0000255|PROSITE-ProRule:PRU00108

Chain	Residue	Details
A	ARG137-ARG196
E	ARG137-ARG196
I	ARG137-ARG196
M	ARG137-ARG196

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site_id	SWS_FT_FI2
Number of Residues	720
Details	DNA_BIND: T-box => ECO:0000250|UniProtKB:Q99593, ECO:0000255|PROSITE-ProRule:PRU00201

Chain	Residue	Details
A	LEU1058-GLY1238
E	LEU1058-GLY1238
I	LEU1058-GLY1238
M	LEU1058-GLY1238

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