5FIC
Open form of murine Acid Sphingomyelinase in presence of lipid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Sphingomyelin phosphodiesterase | polymer | 538 | 60431.6 | 4 | UniProt (Q04519) Pfam (PF00149) Pfam (PF19272) In PDB | Mus musculus (Mouse) | Acid sphingomyelinase,aSMase |
2 | E, I | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
3 | F, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
4 | G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
5 | D, A, B, C | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
6 | C, D, A, B | PHOSPHATE ION | non-polymer | 95.0 | 7 | Chemie (PO4) | |||
7 | C, D, A, B | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
8 | D, A | octadecylphosphonic acid | non-polymer | 334.5 | 2 | Chemie (6E0) | |||
9 | C, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
10 | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 84 - 611 (UniProt: Q04519)
PDB | External Database | Details |
---|---|---|
Asp 74 | - | expression tag |
Arg 75 | - | expression tag |
His 76 | - | expression tag |
His 77 | - | expression tag |
His 78 | - | expression tag |
His 79 | - | expression tag |
His 80 | - | expression tag |
His 81 | - | expression tag |
Lys 82 | - | expression tag |
Leu 83 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 241726.5 | |
Branched | Number of molecules | 6 |
Total formula weight | 3163.0 | |
Non-Polymers* | Number of molecules | 24 |
Total formula weight | 2476.7 | |
All* | Total formula weight | 247366.2 |