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5FIC

Open form of murine Acid Sphingomyelinase in presence of lipid

Functional Information from GO Data
ChainGOidnamespacecontents
A0001778biological_processplasma membrane repair
A0004767molecular_functionsphingomyelin phosphodiesterase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005811cellular_componentlipid droplet
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006672biological_processceramide metabolic process
A0006685biological_processsphingomyelin catabolic process
A0008203biological_processcholesterol metabolic process
A0008270molecular_functionzinc ion binding
A0009410biological_processresponse to xenobiotic stimulus
A0009615biological_processresponse to virus
A0010212biological_processresponse to ionizing radiation
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0023021biological_processtermination of signal transduction
A0034340biological_processresponse to type I interferon
A0034480molecular_functionphosphatidylcholine phospholipase C activity
A0034612biological_processresponse to tumor necrosis factor
A0034644biological_processcellular response to UV
A0035307biological_processpositive regulation of protein dephosphorylation
A0036019cellular_componentendolysosome
A0042060biological_processwound healing
A0042220biological_processresponse to cocaine
A0042599cellular_componentlamellar body
A0043065biological_processpositive regulation of apoptotic process
A0045807biological_processpositive regulation of endocytosis
A0046513biological_processceramide biosynthetic process
A0046598biological_processpositive regulation of viral entry into host cell
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0061750molecular_functionacid sphingomyelin phosphodiesterase activity
A0070555biological_processresponse to interleukin-1
A0071277biological_processcellular response to calcium ion
B0001778biological_processplasma membrane repair
B0004767molecular_functionsphingomyelin phosphodiesterase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005811cellular_componentlipid droplet
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006672biological_processceramide metabolic process
B0006685biological_processsphingomyelin catabolic process
B0008203biological_processcholesterol metabolic process
B0008270molecular_functionzinc ion binding
B0009410biological_processresponse to xenobiotic stimulus
B0009615biological_processresponse to virus
B0010212biological_processresponse to ionizing radiation
B0016787molecular_functionhydrolase activity
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0023021biological_processtermination of signal transduction
B0034340biological_processresponse to type I interferon
B0034480molecular_functionphosphatidylcholine phospholipase C activity
B0034612biological_processresponse to tumor necrosis factor
B0034644biological_processcellular response to UV
B0035307biological_processpositive regulation of protein dephosphorylation
B0036019cellular_componentendolysosome
B0042060biological_processwound healing
B0042220biological_processresponse to cocaine
B0042599cellular_componentlamellar body
B0043065biological_processpositive regulation of apoptotic process
B0045807biological_processpositive regulation of endocytosis
B0046513biological_processceramide biosynthetic process
B0046598biological_processpositive regulation of viral entry into host cell
B0046718biological_processsymbiont entry into host cell
B0046872molecular_functionmetal ion binding
B0061750molecular_functionacid sphingomyelin phosphodiesterase activity
B0070555biological_processresponse to interleukin-1
B0071277biological_processcellular response to calcium ion
C0001778biological_processplasma membrane repair
C0004767molecular_functionsphingomyelin phosphodiesterase activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005764cellular_componentlysosome
C0005768cellular_componentendosome
C0005811cellular_componentlipid droplet
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006672biological_processceramide metabolic process
C0006685biological_processsphingomyelin catabolic process
C0008203biological_processcholesterol metabolic process
C0008270molecular_functionzinc ion binding
C0009410biological_processresponse to xenobiotic stimulus
C0009615biological_processresponse to virus
C0010212biological_processresponse to ionizing radiation
C0016787molecular_functionhydrolase activity
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0023021biological_processtermination of signal transduction
C0034340biological_processresponse to type I interferon
C0034480molecular_functionphosphatidylcholine phospholipase C activity
C0034612biological_processresponse to tumor necrosis factor
C0034644biological_processcellular response to UV
C0035307biological_processpositive regulation of protein dephosphorylation
C0036019cellular_componentendolysosome
C0042060biological_processwound healing
C0042220biological_processresponse to cocaine
C0042599cellular_componentlamellar body
C0043065biological_processpositive regulation of apoptotic process
C0045807biological_processpositive regulation of endocytosis
C0046513biological_processceramide biosynthetic process
C0046598biological_processpositive regulation of viral entry into host cell
C0046718biological_processsymbiont entry into host cell
C0046872molecular_functionmetal ion binding
C0061750molecular_functionacid sphingomyelin phosphodiesterase activity
C0070555biological_processresponse to interleukin-1
C0071277biological_processcellular response to calcium ion
D0001778biological_processplasma membrane repair
D0004767molecular_functionsphingomyelin phosphodiesterase activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005764cellular_componentlysosome
D0005768cellular_componentendosome
D0005811cellular_componentlipid droplet
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006672biological_processceramide metabolic process
D0006685biological_processsphingomyelin catabolic process
D0008203biological_processcholesterol metabolic process
D0008270molecular_functionzinc ion binding
D0009410biological_processresponse to xenobiotic stimulus
D0009615biological_processresponse to virus
D0010212biological_processresponse to ionizing radiation
D0016787molecular_functionhydrolase activity
D0016798molecular_functionhydrolase activity, acting on glycosyl bonds
D0023021biological_processtermination of signal transduction
D0034340biological_processresponse to type I interferon
D0034480molecular_functionphosphatidylcholine phospholipase C activity
D0034612biological_processresponse to tumor necrosis factor
D0034644biological_processcellular response to UV
D0035307biological_processpositive regulation of protein dephosphorylation
D0036019cellular_componentendolysosome
D0042060biological_processwound healing
D0042220biological_processresponse to cocaine
D0042599cellular_componentlamellar body
D0043065biological_processpositive regulation of apoptotic process
D0045807biological_processpositive regulation of endocytosis
D0046513biological_processceramide biosynthetic process
D0046598biological_processpositive regulation of viral entry into host cell
D0046718biological_processsymbiont entry into host cell
D0046872molecular_functionmetal ion binding
D0061750molecular_functionacid sphingomyelin phosphodiesterase activity
D0070555biological_processresponse to interleukin-1
D0071277biological_processcellular response to calcium ion
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:27435900, ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB, ECO:0007744|PDB:5FIC, ECO:0007744|PDB:5HQN
ChainResidueDetails
AASP204
BASN316
BHIS423
BHIS455
CASP204
CHIS206
CASP276
CASN316
CHIS423
CHIS455
DASP204
AHIS206
DHIS206
DASP276
DASN316
DHIS423
DHIS455
AASP276
AASN316
AHIS423
AHIS455
BASP204
BHIS206
BASP276

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB, ECO:0007744|PDB:5FIC, ECO:0007744|PDB:5HQN
ChainResidueDetails
AHIS457
BHIS457
CHIS457
DHIS457

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Cleavage; by CASP7 => ECO:0000305|PubMed:35705808
ChainResidueDetails
AASP249
BASP249
CASP249
DASP249

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P17405
ChainResidueDetails
ASER506
BSER506
CSER506
DSER506

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00415, ECO:0000269|PubMed:27435900, ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB
ChainResidueDetails
AASN84
BASN84
CASN84
DASN84

site_idSWS_FT_FI6
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00415, ECO:0000269|PubMed:27435900, ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB, ECO:0007744|PDB:5HQN
ChainResidueDetails
AASN173
AASN333
BASN173
BASN333
CASN173
CASN333
DASN173
DASN333

site_idSWS_FT_FI7
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00415, ECO:0000269|PubMed:27435900, ECO:0007744|PDB:5FI9, ECO:0007744|PDB:5FIB, ECO:0007744|PDB:5FIC, ECO:0007744|PDB:5HQN
ChainResidueDetails
AASN393
AASN518
BASN393
BASN518
CASN393
CASN518
DASN393
DASN518

site_idSWS_FT_FI8
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00415
ChainResidueDetails
AASN611
BASN611
CASN611
DASN611

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PDB entries from 2024-07-24

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