5FI0

Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein	polymer	374	43066.6	4	UniProt (Q8TCU6) Pfam (PF00621) Pfam (PF22697)	Homo sapiens (Human)	PtdIns(3,4,5)-dependent Rac exchanger 1,PtdIns(3,4,5)-dependent Rac exchanger 1
2	B, D, F, H (B, D, F, H)	Ras-related C3 botulinum toxin substrate 1	polymer	195	21811.5	4	UniProt (P63000) Pfam (PF00071)	Homo sapiens (Human)	Cell migration-inducing gene 5 protein,Ras-like protein TC25,p21-Rac1
3	I, J, K, L (A, C, E, G)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)

Sequence modifications

A, C, E, G: 38 - 201 (UniProt: Q8TCU6)

PDB	External Database	Details
Gly -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

A, C, E, G: 202 - 408 (UniProt: Q8TCU6)
B, D, F, H: 1 - 192 (UniProt: P63000)

PDB	External Database	Details
Gly -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	259512.2
Non-Polymers*	Number of molecules	4
	Total formula weight	379.9
All*	Total formula weight	259892.1

*Water molecules are not included.