5F8T
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
Replaces: 4ZJ5Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Plasma kallikrein light chain | polymer | 239 | 26913.6 | 1 | UniProt (P03952) Pfam (PF00089) In PDB | Homo sapiens (Human) | Fletcher factor,Kininogenin,Plasma prekallikrein,PKK |
| 2 | P | CYS-PRO-LYS-ARG-PHE-M70-ALA-LEU-PHE-CYS | polymer | 10 | 1157.5 | 1 | synthetic construct | ||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | P | piperidine-1-carboximidamide | non-polymer | 127.2 | 1 | Chemie (MRZ) | |||
| 5 | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 16 - 246 (UniProt: P03952)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 503 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28071.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 511.4 | |
| All* | Total formula weight | 28582.5 |
