5F8T

The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2

Replaces:  4ZJ5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SO4 A 301

Chain	Residue
A	TRP24
A	GLY25
A	TRP27
A	PRO28
A	GLY69
A	ILE70
A	LEU71
A	PHE117
A	HOH433

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 302

Chain	Residue
A	LEU37
A	THR38
A	ALA38
A	LYS119
A	LYS185

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
A	TYR184
A	GLY186
A	LYS186
A	HOH485

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	GLU26
A	TRP27
A	TRP137
A	LYS157

---

site_id	AC5
Number of Residues	10
Details	binding site for residue MRZ P 100

Chain	Residue
A	ASP189
A	ALA190
A	THR213
A	SER214
A	GLY216
A	GLY219
A	GLY226
A	HOH477
P	PHE5
P	ALA6

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	235
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3521732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3521732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---