5F1B

Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	GP1	polymer	158	17194.5	1	UniProt (P87666) Pfam (PF01611)	Zaire ebolavirus (ZEBOV)	GP1,2,GP
2	B (B)	GP2	polymer	130	14882.8	1	UniProt (P87666) Pfam (PF22307)	Zaire ebolavirus (ZEBOV)	GP1,2,GP
3	C (C)	Niemann-Pick C1 protein	polymer	256	29436.6	1	UniProt (O15118) Pfam (PF22314)	Homo sapiens (Human)
4	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E, F, G (A, B, C)	water	water		18.0	171	Chemie (HOH)

Sequence modifications

A: 32 - 188 (UniProt: P87666)

PDB	External Database	Details
Arg 31	-	expression tag
Val 42	Thr 42	engineered mutation

B: 509 - 632 (UniProt: P87666)

PDB	External Database	Details
His 633	-	expression tag
His 634	-	expression tag
His 635	-	expression tag
His 636	-	expression tag
His 637	-	expression tag
His 638	-	expression tag

C: 2 - 248 (UniProt: O15118)

PDB	External Database	Details
Met 1	-	expression tag
Leu 249	-	expression tag
Glu 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag
His 256	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	61513.9
Branched	Number of molecules	1
	Total formula weight	424.4
All*	Total formula weight	61938.3

*Water molecules are not included.