5EJK

Crystal structure of the Rous sarcoma virus intasome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Gag-Pro-Pol polyprotein	polymer	270	30574.5	8	UniProt (P03354) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) In PDB	Rous sarcoma virus (strain Prague C) (RSV-PrC)
2	I, L	RSV Integrase	polymer	42	13047.5	2		Rous sarcoma virus (strain Schmidt-Ruppin E)
3	J, M	DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*TP*AP*CP*TP*C)-3')	polymer	22	6716.4	2		Rous sarcoma virus (strain Schmidt-Ruppin E)
4	K, N	DNA (5'-D(*CP*TP*TP*CP*TP*CP*TP*C)-3')	polymer	8	2343.6	2		Homo sapiens
5	k, n	DNA (5'-D(*AP*GP*TP*GP*TP*CP*TP*T)-3')	polymer	8	2432.6	2		Homo sapiens
6	G, H, A, C, D...	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
7	B, F, G, A	TUNGSTEN ION	non-polymer		183.8	36	Chemie (W)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 270 (UniProt: P03354)

PDB	External Database	Details
Ser 23	Cys 1303	engineered mutation
Mse 112	Leu 1392	engineered mutation
Mse 135	Leu 1415	engineered mutation
Mse 162	Leu 1442	engineered mutation
Mse 163	Leu 1443	engineered mutation
Lys 166	Arg 1446	conflict
Mse 188	Leu 1468	engineered mutation
Mse 189	Leu 1469	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	293675.8
Non-Polymers*	Number of molecules	44
	Total formula weight	7141.5
All*	Total formula weight	300817.3

*Water molecules are not included.